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Contents Molecular Cancer Therapeutics The Cancer Drug Development Journal: From Concept to Clinic March 2011 Volume 10 Number 3 437 Highlights of This Issue 373 SPOTLIGHT ON MOLECULAR PROFILING 375 Global microRNA Analysis of the NCI-60 Cancer Cell Panel Jeffim N. Kuznetsov, Guy J. Leclerc, Gilles M. Leclerc, and Julio C. Barredo Rolf Søkilde, Bogumil Kaczkowski, Agnieszka Podolska, Susanna Cirera, Jan Gorodkin, Søren Møller, and Thomas Litman 448 BRAFV600E: Implications for Carcinogenesis and Molecular Therapy 461 Emma R. Cantwell-Dorris, John J. O’Leary, and Orla M. Sheils 395 Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors 472 sFLT01: A Novel Fusion Protein with Antiangiogenic Activity 481 Rebecca G. Bagley, Leslie Kurtzberg, William Weber, Tri-Hung Nguyen, Stephanie Roth, Roy Krumbholz, Min Yao, Brenda Richards, Mindy Zhang, Peter Pechan, Steve Schmid, Abraham Scaria, Johanne Kaplan, and Beverly A. Teicher Studies on Mechanism of Action of Anticancer Peptides by Modulation of Hydrophobicity Within a Defined Structural Framework PRECLINICAL DEVELOPMENT 495 Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation Increased Sensitivity to Thiopurines in Methylthioadenosine Phosphorylase–Deleted Cancers Sally A. Coulthard, Christopher P.F. Redfern, Svante Vikingsson, Malin Lindqvist-Appell, Karin Skoglund, Ingrid Jakobsen-Falk, Andrew G. Hall, Gordon A. Taylor, and Linda A. Hogarth Nancy B. Kuemmerle, Evelien Rysman, Portia S. Lombardo, Alison J. Flanagan, Brea C. Lipe, Wendy A. Wells, Jason R. Pettus, Heather M. Froehlich, Vincent A. Memoli, Peter M. Morganelli, Johannes V. Swinnen, Luika A. Timmerman, Leila Chaychi, Catherine J. Fricano, Burton L. Eisenberg, William B. Coleman, and William B. Kinlaw Integrating Targets, Technologies, and Treatments JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling Lanxi Song, Bhupendra Rawal, Jeffrey A. Nemeth, and Eric B. Haura Yi-bing Huang, Xiao-fei Wang, Hong-ye Wang, Yu Liu, and Yuxin Chen 427 Comprehensive Evaluation of the Contribution of X Chromosome Genes to Platinum Sensitivity Eric R. Gamazon, Hae Kyung Im, Peter H. O’Donnell, Dana Ziliak, Amy L. Stark, Nancy J. Cox, M. Eileen Dolan, and Rong Stephanie Huang THERAPEUTIC DISCOVERY 416 Targeting Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase 2 by Curcumin Induces ER StressAssociated Apoptosis for Treating Human Liposarcoma Lu Wang, Lingxian Wang, Ran Song, Yan Shen, Yang Sun, Yanhong Gu, Yongqian Shu, and Qiang Xu Eduardo Vilar, Jose Perez-Garcia, and Josep Tabernero 404 ORAI1-mediated Calcium Influx in Lactation and in Breast Cancer Damara McAndrew, Desma M. Grice, Amelia A. Peters, Felicity M. Davis, Teneale Stewart, Michelle Rice, Chanel E. Smart, Melissa A. Brown, Paraic A. Kenny, Sarah J. Roberts-Thomson, and Gregory R. Monteith REVIEWS 385 AMPK and Akt Determine Apoptotic Cell Death Following Perturbations of One-carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia iii www.aacrjournals.org Downloaded from mct.aacrjournals.org on June 15, 2017. © 2011 American Association for Cancer Research. 505 Connexin-26 Is a Key Factor Mediating Gemcitabine Bystander Effect 550 Laura Garcia-Rodrı́guez, Sandra Perez-Torras, Meritxell Carrió, Anna Cascante, Ignacio Garcı́a-Ribas, Adela Mazo, and Cristina Fillat 518 Liping Xu, Shuping Yin, and Kaladhar B. Reddy Synergistic Effects of Foretinib with HER-Targeted Agents in MET and HER1- or HER2-Coactivated Tumor Cells MOLECULAR MEDICINE IN PRACTICE 558 Li Liu, Hong Shi, Yuan Liu, Amber Anderson, John Peterson, James Greger, Anne-Marie Martin, and Tona M. Gilmer 531 PIK3CA Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors Filip Janku, Apostolia M. Tsimberidou, Ignacio Garrido-Laguna, Xuemei Wang, Rajyalakshmi Luthra, David S. Hong, Aung Naing, Gerald S. Falchook, John W. Moroney, Sarina A. Piha-Paul, Jennifer J. Wheler, Stacy L. Moulder, Siqing Fu, and Razelle Kurzrock Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters, OCTs, and Multidrug and Toxic Compound Extrusion Proteins, MATEs Tsuyoshi Minematsu and Kathleen M. Giacomini 540 Enhanced Anticancer Effect of the Combination of Cisplatin and TRAIL in Triple-Negative Breast Tumor Cells Antagonism of VEGF by Genetically Engineered Dendritic Cells Is Essential to Induce Antitumor Immunity against Malignant Ascitis Masahiko Sugiyama, Yoshihiro Kakeji, Yui Harada, Mitsuho Onimaru, Kumi Yoshida, Sakura Tanaka, Yasunori Emi, Masaru Morita, Yosuke Morodomi, Mamoru Hasegawa, Yoshihiko Maehara, and Yoshikazu Yonemitsu ABOUT THE COVER VEGF and placental growth factor promote angiogenesis in developing tumors. A novel fusion protein sFLT01 neutralized VEGF and PlGF, and inhibited tumor growth and blood vessel development in preclinical tumor models. Using immunofluorescence, it was found that sFLT01 localized to vascular areas in human A673 Ewing’s sarcoma tumors. VEGFR2 protein was also detected throughout the tumor microenvironment. For details, see article by Bagley and colleagues on page 404. iv Molecular Cancer Therapeutics Downloaded from mct.aacrjournals.org on June 15, 2017. © 2011 American Association for Cancer Research. 10 (3) Mol Cancer Ther 2011;10:373-565. Updated version E-mail alerts Reprints and Subscriptions Permissions Access the most recent version of this article at: http://mct.aacrjournals.org/content/10/3 Sign up to receive free email-alerts related to this article or journal. To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department at [email protected]. To request permission to re-use all or part of this article, contact the AACR Publications Department at [email protected]. Downloaded from mct.aacrjournals.org on June 15, 2017. © 2011 American Association for Cancer Research.