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VENOUS RETURN FILLING TIME VR = EDV FT = EDV VR = EDV FT = EDV INCREASED BY VASOCONSTRICTION AFTERLOAD tension required to open semilunar valves & eject blood PRELOAD degree of ventricular stretching END-DIASTOLIC VOLUME (EDV) END-SYTOLIC VOLUME (ESV) HORMONES amt. of blood in ventricles at end of diastole amt. of blood in ventricles at end of systole norepinephrine, epinephrine, and T3 VENOUS RETURN rate of blood flow through veins FILLING TIME duration of ventricular diastole STROKE VOLUME amount of blood pumped by L. ventricle per heart beat (ml/beats) (SV = EDV - ESV) CARDIAC OUTPUT CO = SV x HR DECREASED BY VASODILATION STROKE VOLUME (SV) CONTRACTILITY OF CARDIAC MUSCLE CELLS INCREASED BY S.D. OF ANS DECREASED BY P.D. OF ANS EDV = SV ESV = SV HEART RATE (HR) = beats/min EDV = SV ESV = SV VR = HR CARDIAC OUTPUT (C0) = ml/min amt. of blood pumped by L. ventricle/min