Download Curriculum Vitae - Bioimaging Sciences

Name:
Dorit Granot, PhD
Department of Diagnostic Radiology, Yale University, School of Medicine
TAC NL47
New Haven, CT 06520-8356
e.mail: [email protected]
Tel: (203) 785-5648
Education:
Sep 2007-
Postdoctoral Fellow, Laboratory of Dr. Erik M. Shapiro, Department of Diagnostic
Radiology, Yale University, New Haven, CT.
2001-2007
Weizmann Institute of Science, Rehovot, Israel.
Feinberg Graduate School, Faculty of Life Science, Department of Biological
Regulation, Ph.D program.
Mentor: Prof. Michal Neeman.
Thesis: Fibroblasts labeling for in vivo detection by Magnetic Resonance Imaging.
1997-2000
Hebrew University of Jerusalem, Jerusalem, Israel.
Faculty of Life Science, Givat Ram, Department of Physiology.
MSc. program.
Mentor: Prof. Shimon Schuldiner
Thesis: Structure Function Studies in EmrE – an Escherichia Coli Multidrug
Transporter.
MSc. degree, July 2000 (completion date).
1994-1997
Hebrew University of Jerusalem, Jerusalem, Israel.
Faculty of Life Science, Givat Ram, BSc. Studies.
BSc. degree, July 1997 (completion date).
Honors:
2007 Finalist, International Society for Magnetic Resonance in Medicine “Hot topics in
cancer” competition, Germany..
2006 AACR-AFLAC Scholar-in-training Award, Mouse Models of Cancer, Cambridge,
Massachusetts.
Teaching Experience:
1998-present training undergrads, rotational and summer students at the laboratories of
prof. Shimon Schuldiner at the Hebrew University of Jerusalem, prof.
Michal Neeman at the Weiazmann Institute of Science and Dr. Erik M.
Shapiro at Yale University.
1998-2000
Teaching biology and chemistry courses in after school programs to
elementary through high school students.
List of Publication:
1. In vivo imaging of fibroblasts recruitment into ovarian carcinoma tumors. Granot D, Addadi
Y, Kalchenko V, Kunz-Schughart L. A, and Neeman M. Cancer Res. 2007 Oct
1;67(19):9180-9.
2. Labeling fibroblasts with biotin-BSA-GdDTPA-FAM for tracking of tumor-associated
stroma by fluorescence and MR imaging. Granot D, Kunz-Schughart L.A, Neeman M. Magn
Reson Med. 2005 Oct;54(4):789-97.
3. Longitudinal MRI tracking of the angiogenic response to hind limb ischemic injury in the
mouse. Ziv K, Nevo N, Dafni H, Israely T, Granot D, Brenner O, Neeman M. Magn Reson
Med. 2004 Feb;51(2):304-11.
4. Vascular remodeling and angiogenesis in ectopic ovarian transplants: a crucial role of
pericytes and vascular smooth muscle cells in maintenance of ovarian grafts. Israely T, Dafni
H, Granot D, Nevo N, Tsafriri A, Neeman M. Biol Reprod. 2003 Jun;68(6):2055-64. Epub
2003 Jan 22.
5. Small is mighty: EmrE, a multidrug transporter as an experimental paradigm. Schuldiner S,
Granot D, Mordoch SS, Ninio S, Rotem D, Soskin M, Tate CG, Yerushalmi H. News
Physiol Sci. 2001 Jun;16:130-4. Review.
6. Precious Things Come in Little Packages. Schuldiner S, Granot D, Mordoch SS, Ninio S,
Rotem D, Soskin M, Yerushalmi H. J Mol Microbiol Biotechnol. 2001 Apr; 3(2):155-62.
Review.
7. Scanning Cysteine Accessibility of EmrE, an H+-coupled Multidrug Transporter from
Escherichia coli, Reveals a Hydrophobic Pathway for Solutes. Steiner Mordoch, S., Granot,
D., Lebendiker, M., and Schuldiner, S. (1999) J. Biol. Chem. 274, p. 1480-86.
Invited review
8. Ziv, K., Granot, D., Plaks, V., Cohen, B., and Neeman, M. Molecular imaging of reporter
genes. Invited book chapter “Molecular and Cellular Imaging”, CRC, Mike Modo, Jeff Bulte
editors, 2006.
Poster presentations:
9. 2007 Dorit Granot, Yoseph Addadi, Vyacheslav Kalchenko, L. A. Kunz Schughart and
Michal Neeman. Stroma fibroblasts are recruited systemically to contribute to the
tumor angiogenic rim: Cell tracking by MRI and two photon microscopy Presented in:
15th ISMRM conference, Berlin, Germany.
10, 11 2006 Dorit Granot, Yoseph Addadi, Vyacheslav Kalchenko and Michal Neeman
In vivo imaging of fibroblasts recruitment into ovarian carcinoma tumors
Presented in: “Mouse Models of Cancer” American Association of Cancer Research,
Cambridge, Massachusetts. October 2006
In: The clore workshop on “Novel Imaging Technologies in Disease Models”,
Weizmann Institute of Science, Rehovot, Israel. October 2006.
12. 2006 Dorit Granot, Yoseph Addadi, Vyacheslav Kalchenko and Michal Neeman
Fibroblast labeling for in vivo detection by magnetic resonance imaging.
Presented in: The 2nd Joint American-Israeli Conference on Cancer "Novel
Therapeutic Approaches to Cancer", Jerusalem, Israel.
13. 2005 Dorit Granot, Michal Neeman.
In vivo Detection of ex vivo Labeled Fibroblasts with biotin-BSA-GdDTPA.
Presented in: 4th SMI conference, Cologne, Germany
14. 2004 D. Granot, M. Shatz, H. Dafni, L. A. Kunz-Schughart, M. Neeman.
15. 1998
Caveolae mediated labeling of fibroblasts for tracking by MRI
Presented in: 12th ISMRM conference, Kyoto, Japan.
Steiner Mordoch, S., Granot, D., Lebendiker, M., and Schuldiner, S.
Scanning Cysteine Accessibility of EmrE, an H+-coupled Multidrug Transporter from
Escherichia coli, Reveals a Hydrophobic Pathway for Solutes.
Presented in: Ilanit conference, Eilat, Israel.
Oral presentations:
16. 2007 Invited talk at the “Hot topics in cancer” competition, Finalist. ISMRM, Germany.
17. 2006 Invited talk at the clore workshop on “Novel Imaging Technologies in Disease
Models”, Weizmann Institute of Science, Rehovot, Israel. October 2006.
Title of the talk: “Fibroblasts recruitment into subcutaneous ovarian carcinoma
tumors”
18. 2006 Invited talk at the annual meeting of Israeli Club for MR.
Title of the talk: “Fibroblasts labeling for in vivo detection of stroma cell recruitment
by MRI”
19. 2006 ISMRM conference. Oral presentations at the “Cell Tracking and Targeted Contrast
Agents in Cancer” Session. Title of the talk: “Tracking recruitment of fibroblasts to
ovarian carcinoma tumors by MRI”
20. 1998 Ilanit conference. Oral presentations at the “Structure and Function of
Membrane Proteins” session.