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CURRICULUM VITAE DATE PREPARED: January 12, 2009 PART I: General Information Name: JOHN ISAAC LOEWENSTEIN Education: 1969 1973 B.S., MASSACHUSETTS INSTITUTE OF TECHNOLOGY M.D., SUNY, BUFFALO Postdoctoral Training: 01/73-12/74 Intern in Medicine, Medicine, Washington Hospital Center 01/74-12/77 Resident in Ophthalmology, Ophthalmology, Boston University Affiliated Hospitals 01/77-12/79 Fellow in Retina, Retina, Boston University Affiliated Hospitals 01/77-12/79 Research Fellow, Retina, Boston University Medical School Licensure and Certification: 1974 1978 Massachusetts Registered Physician Diplomate, American Board of Ophthalmology Academic Appointments: 1977-1979 1980-1983 1983-1984 1986-1994 1994-1999 1999-2005 20062008- Instructor in Ophthalmology, Boston University Medical School, Boston, MA Assistant Professor of Ophthalmology, Boston University Medical School, Boston, MA Associate Professor of Ophthalmology, Boston University Medical School, Boston, MA Clinical Instructor in Ophthalmology, Harvard Medical School, Boston, MA Instructor in Ophthalmology, Harvard Medical School, Boston, MA Assistant Professor of Ophthalmology, Harvard Medical School, Boston, MA Associate Professor of Ophthalmology, Harvard Medical School Vice Chair for Education, Department of Ophthalmology, Harvard Medical School, Boston, MA Hospital or Affiliated Institution Appointments: 01/77-12/79 Assistant in Ophthalmology, University Hospital, Boston, MA 01/78-12/84 Assistant Director of Ophthalmology, Boston City Hospital, Boston, MA 01/79-12/89 Assistant Visiting Surgeon in Ophthalmology, University Hospital, Boston, MA 01/84-12/85 Director of Ophthalmology, Boston City Hospital, Boston, MA 01/84-12/90 Assistant in Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 01/91-12/95 Assistant Surgeon, Massachusetts Eye and Ear Infirmary, Boston, MA 01/96Surgeon, Massachusetts Eye and Ear Infirmary, Boston, MA Hospital and Health Care Organization Clinical Service Responsibilities: 1978-1984 1985- Attending Physician, Retina Service, University Hospital Attending Physician, Retina Service, Massachusetts Eye and Ear Infirmary Major Administrative Responsibilities: 1994-2008 1996-1997 1997-1998 1997-2003 1997-2003 20022008- Associate Chief of Ophthalmology for Managed Care, Massachusetts Eye and Ear Infirmary President, Ophthalmology Staff, Massachusetts Eye and Ear Infirmary President, Medical Staff, Massachusetts Eye and Ear Infirmary Board Member, Eye Care Excellence Network Co-Medical Director, Eye Care Excellence Network Director of Residency Training in Ophthalmology, Massachusetts Eye and Ear Infirmary Associate Chief of Ophthalmology for Clinical Affairs, Massachusetts Eye and Ear Infirmary Major Committee Assignments: HMS / HSDM 2005- Harvard Residency Managing Committee [Chairperson], Harvard Medical School 2007Practice Advisory Committee, Massachusetts Eye and Ear Infirmary Affiliated Inst 1988-1992 1989-2001 19911994-2004 Social Service Advisory Committee, Massachusetts Eye and Ear Infirmary Quality Assurance Committee, Massachusetts Eye and Ear Infirmary Fellowship Committee, Massachusetts Eye and Ear Infirmary Eye Utilization Review Committee [Chairperson], Massachusetts Eye 19961996-1997 200220022005-2006 2006-2007 2007-2008 and Ear Infirmary Board of Surgeons, Massachusetts Eye and Ear Infirmary Eye Service Executive Committee, Massachusetts Eye and Ear Infirmary Residency Selection Committee [Chairperson], Massachusetts Eye and Ear Infirmary Residency Steering Committee [Chairperson], Massachusetts Eye and Ear Infirmary Vision Rehabilitation Search Committee [Chairperson], Massachusetts Eye and Ear Infirmary Oculoplastics Search Committee [Chairperson], Massachusetts Eye and Ear Infirmary Eye Service Executive Committee, Massachusetts Eye and Ear Infirmary Professional Societies: 19761978197819801999- Massachusetts Society of Eye Physicians and Surgeons, Member (Executive Board 1986-9) Association for Research in Vision and Ophthalmology, Member New England Ophthalmologic Society, Member (Program Committee, 1979) American Academy of Ophthalmology, Member Retina Society, Member Editorial Boards: 1986199520012001200220042004- Ad-Hoc Reviewer, Journal of the American Medical Association Member, Digital Journal of Ophthalmology Ad-Hoc Reviewer, Proceedings of the National Academy of Sciences Ad-Hoc Reviewer, Ophthalmic Surgery and Lasers Ad-Hoc Reviewer, New England Journal of Medicine Ad-Hoc Reviewer, American Journal of Ophthalmology Ad-Hoc Reviewer, Documenta Ophthalmologica Awards and Honors: 1996 1998 2001 2004 2007 Teacher of the Year Award, Massachusetts Eye and Ear Infirmary Distinguished Service Award, Massachusetts Eye and Ear Infirmary Teacher of the Year Award, Massachusetts Eye and Ear Infirmary Scholar, Academy , Harvard Medical School Nominee, Harvard Medical School Prize for Excellence in Teaching (Years 3&4), Harvard Medical School Part II: Bibliography Original Articles 1. Loewenstein JI, Lessell S. Experimental cryosurgical lesion of the optic nerve. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;215(2):97-103. 2. Green GJ, Lessell S, Loewenstein JI. Ischemic optic neuropathy in chronic papilledema. Arch Ophthalmol. 1980;98(3):502-4. 3. Leibowitz HM, Krueger DE, Maunder LR, Milton RC, Kini MM, Kahn HA, Nickerson RJ, Pool J, Colton TL, Ganley JP, Loewenstein JI, Dawber TR. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. Surv Ophthalmol. 1980;24(Suppl):335-610. 4. Lubin JR, Loewenstein JI, Frederick AR. Vogt-Koyanagi-Harada syndrome with focal neurologic signs. Am J Ophthalmol. 1981;91(3):332-41. 5. Loewenstein J. Abnormal Visual Phenomona. Clinical Experience. 1984;1:12-21. 6. Loewenstein JI, Palmberg PF, Connett JE, Wentworth DN. Effectiveness of a pinhole method for visual acuity screening. Arch Ophthalmol. 1985;103(2):222-3. 7. Loewenstein JI. Visual hallucinations in patients with choroidal neovascularization. JAMA. 1994;272(3):243. 8. Loewenstein JI. Bilateral macular holes in von Hippel-Lindau disease. Arch Ophthalmol. 1995;113(2):143-4. 9. Loewenstein JI, Hogan RN, Jakobiec FA. Osseous metaplasia in a preretinal membrane. Arch Ophthalmol. 1997;115(1):117-9. 10. Loewenstein JI. Clinical practice guidelines. Int Ophthalmol Clin. 1998;38(3):75-85. 11. Loewenstein JI. Introduction to capitation. Int Ophthalmol Clin. 1998;38(3):101-6. 12. Loewenstein JI. Overview of quality measurement and improvement. Int Ophthalmol Clin. 1998;38(3):59-68. 13. Kim RY, Loewenstein JI. Systemic diseases manifesting as exudative retinal detachment. Int Ophthalmol Clin. 1998;38(1):177-95. 14. Harris EW, Loewenstein JI, Azar D. Vitamin A deficiency and its effects on the eye. Int Ophthalmol Clin. 1998;38(1):155-61. 15. Zacks DN, Samson CM, Loewenstein J, Foster CS. Electroretinograms as an indicator of disease activity in birdshot retinochoroidopathy. Graefes Arch Clin Exp Ophthalmol. 2002;240(8):601-7. 16. EyeTech Study Group. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology. 2003;240:601-7. 17. Ray S, Loewenstein J. Atypical manifestation of multiple evanescent white dot syndrome with large peripapillary lesion. Arch Ophthalmol. 2003;121(12):1794-6. 18. Rizzo JF, Wyatt J, Loewenstein J, Kelly S, Shire D. Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays. Invest Ophthalmol Vis Sci. 2003;44(12):5355-61. 19. Rizzo JF, Wyatt J, Loewenstein J, Kelly S, Shire D. Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. Invest Ophthalmol Vis Sci. 2003;44(12):5362-9. 20. Husain D, Loewenstein JI. Surgical approaches to retinal prosthesis implantation. Int Ophthalmol Clin. 2004;44(1):105-11. 21. Loewenstein JI, Montezuma SR, Rizzo JF. Outer retinal degeneration: an electronic retinal prosthesis as a treatment strategy. Arch Ophthalmol. 2004;122(4):587-96. 22. Ray S, Friberg TA, Beatty RR, Loewenstein J. Late posterior migration of glass intraocular foreign bodies. Arch Ophthalmol. 2004;122(6):923-6. 23. Hatton MP, Loewenstein J. Attrition from ophthalmology residency programs. Am J Ophthalmol. 2004;138(5):863-4. 24. Lee MS, Gupta N, Penson RT, Loewenstein J, Wepner MS, Seiden MV, Milam AH. Cone damage in patients receiving high-dose irofulven treatment. Arch Ophthalmol. 2005;123(1):29-34. 25. Durand ML, Kim IK, D'Amico DJ, Loewenstein JI, Tobin EH, Kieval SJ, Martin SS, Azar DT, Miller FS, Lujan BJ, Miller JW. Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin. Am J Ophthalmol. 2005;140(3):552-4. 26. Krzystolik MG, Filippopoulos T, Ducharme JF, Loewenstein JI. Pegaptanib as an adjunctive treatment for complicated neovascular diabetic retinopathy. Arch Ophthalmol. 2006;124(6):920-1. 27. Henderson BA, Neaman A, Kim BH, Loewenstein J. Virtual training tool. Ophthalmology. 2006;113(6):1058-9. 28. Ament CS, Zacks DN, Lane AM, Krzystolik M, D'Amico DJ, Mukai S, Young LH, Loewenstein J, Arroyo J, Miller JW. Predictors of visual outcome and choroidal neovascular membrane formation after traumatic choroidal rupture. Arch Ophthalmol. 2006;124(7):957-66. 29. Montezuma SR, Loewenstein J, Scholz C, Rizzo JF. Biocompatibility of materials implanted into the subretinal space of yucatan pigs. Invest Ophthalmol Vis Sci. 2006;47(8):3514-22. 30. Warden SM, Pachydaki SI, Christoforidis JB, D'Amico DJ, Loewenstein JI. Choroidal neovascularization after epiretinal membrane removal. Arch Ophthalmol. 2006;124(11):1652-4. 31. Andreoli CM, Husain D, Davis TS, Loewenstein JI. Chorioretinal changes heralding metastatic malignancy. Arch Ophthalmol. 2006;124(12):1790-2. 32. Ho J, Loewenstein JI. Endophthalmitis associated with intravitreal injections. Int Ophthalmol Clin. 2007;47(2):199-208. 33. Singh RP, Hatton M, Sprich S, Loewenstein J. Posttraumatic stress. Ophthalmology. 2007;114(6):1238. 34. Ahmed E, Loewenstein J. Leber congenital amaurosis: disease, genetics and therapy. Semin Ophthalmol. 2008;23(1):39-43. 35. de Bruin DM, Burnes D, Loewenstein J, Chen Y, Chang S, Chen T, Esmaili D, de Boer JF. In-vivo three-dimensional imaging of neovascular age related macular degeneration using optical frequency domain imaging at 1050 nm. Invest Ophthalmol Vis Sci. 2008. Reviews/Chapters/Editorials 1. Loewenstein J. Vitrectomy. In: Snow JC Ed. Anesthesia in Otolaryngology and Ophthalmology. New York: Appleton Century Crofts;1982. 2. Loewenstein J, Putnoi D. Common Ocular Problems. In: Noble J, ed. Textbook of General Medicine and Primary Care. Boston/Toronto: Little, Brown;1987. p. 705722. 3. Loewenstein J. Eye Emergencies. In: Noble J, ed. Textbook of General Medicine and Primary Care. Boston/Toronto: Little, Brown;1987. p. 689-703. 4. Loewenstein J. The Eye in Systemic Disease. In: Noble J, ed. Textbook of General Medicine and Primary Care. Boston/Toronto: Little, Brown;1987. p. 737-743. 5. Loewenstein J. The Ocular Examination. In: Noble J, ed. Textbook of General Medicine and Primary Care. Boston/Toronto: Little, Brown;1987. p. 683-687. 6. Rizzo JF, Loewenstein J, Wyatt J. Development of an Epiretinal Electronic Visual Prosthesis. In: Hollyfield JG, ANderson RE, LaVail MM, eds. Retinal Degenerative Diseases and Experimental Therapy. New York: Plenum Publishers;1999. p. 463469. 7. Loewenstein J. Retinopathy associated with blood anomalies. In: Albert D, Jakobiec F, editors. Principles and Practice of Ophthalmology. Philadelphia: W.B. Saunders;1999. 8. Friedman D Loewenstein J. Strategies for improving the physician-patient relationship. In: Albert D, Jakobiec F. Principles and Practice of Ophthalmology. Philadelphia: W.B. Saunders;1999. 9. Reddy HS, Loewenstein JI. Visual Function. In: Loewenstein JI and Lee S, eds. Ophthalmology: Just the Facts. New York: McGraw-Hill;2003. 10. Loewenstein JI. Vitreous, Retina, and Choroid. In: Loewenstein JI and Lee S, eds. Ophthalmology: Just the Facts. New York: McGraw-Hill;2003. 11. Loewenstein JI, Warden SM, Rizzo JF. Visual Prostheses. In: Hartnett ME, ed. Pediatric Retinal Disease: Medical and Surgical Approaches. Philadelphia: Lippincott Williams and Wilkins;2004. Books, Monographs, and Textbooks 1. Loewenstein J, editor, section on ophthalmology; In Noble J, editor. Textbook of General Medicine and Primary Care. Boston: Little, Brown;1987. p. 683-743. 2. Loewenstein J, editor. Managed Care. In: International Ophthalmology Clinics. Volume 38 Philadelphia: Lippincott-Raven;1998. 3. Loewenstein JI and Lee S, editors. Ophthalmology: Just the Facts. New York: McGraw-Hill;2003. Abstracts 1. Shahin ME, Rizzo JF, Wyatt J, Loewenstein J. Evaluation of external electrical stimulation studies. Inv Ophthalmol Vis Sci Suppl. 2000;40:S860. 2. Loewenstein JI, Rizzo JF, Montezuma SR. Implantation of subretinal polyimide in Yucatan pigs. . Inv ophthalmol Vis Sci Suppl. 2002;43:S178. 3. Shire DB, Rizzo JF, Loewenstein JI. Micromachined tacks to attach a prosthesis to the retina. . Inv Ophthalmol Vis Sci Suppl. 2002;43:S179. 4. Ament CS, Zacks D, Lane AM, D’Amico DJ, Young L, Mukai S, Loewenstein J,Gragoudas E, Arroyo J, Miller J . Traumatic choroidal rupture: visual outcome and treatment of choroidal vascular membranes. . Inv. Ophthalmol. Vis Sci Suppl. . 2002;43:S179. 5. Shire DB, Gingerich M, Theogarajan L, Wyatt J, Loewenstein J, Montezuma S, Rizzo J. Packaging development for retinal prosthesis. Inv. Ophthalmol. Vis Sci Suppl. 2003;44:S210. 6. Lee MS, Gupta N, Loewenstein JI, Wepner M, Milam AM. Retinal cone toxicity in an ovarian cancer patient treated with Irofulven. Inv. Ophthalmol. Vis Sci Suppl. 2003;44:S21. 7. Rizzo JF, Jensen RJ, Loewenstein J, Wyatt J. Unexpectedly small percepts evoked by epi-retinal electrical stimulation in blind humans. Inv. Ophthalmol. Vis Sci Suppl. . 2003;44:S174. 8. Iaccheri B, Fiore T, Androudi S, Papadaki T, Loewenstein JI, Miller JW, Young LHY, D’Amico D, Foster CS. Acute posterior multifocal placoid pigment epitheliopathy (APMPPE): final outcome and visual prognosis. Inv. Ophthalmol. Vis. Sci. Suppl. 2004;45:2692. 9. Montezuma SR, Loewenstein J, Scholz C, Rizzo JF. Biocompatibility of subretinal materials in Yucatan pigs. Inv. Ophthalmol. Vis Sci Suppl. 2004;45:4169. 10. Rizzo JF, Wyatt JL, Loewenstein J, Montezuma S, Shire DB, Theogarajan L, Kelly SK. Development of a wireless, ab externo retinal prosthesis. Inv. Ophthalmol. Vis Sci Suppl. 2004;45:45. 11. Reddy HS, Loewenstein JI, Lane A, Shen L. Peripapillary choroidal neovascularization. Inv. Ophthalmol. Vis Sci Suppl. 2004;45:3077. 12. Sun JK, Montezuma SR, Loewenstein J, Rizzo JF. Progress toward a minimally invasive ab externo technique for subretinal prosthetic implantation. Inv. Ophthalmol. Vis Sci Suppl. 2004;45:4190. 13. J. Chen, J. Loewenstein, H.A. Shah, C.D. Herbert, J.F. Rizzo. Extraction of a Chronically Implanted Sub-Retinal Electrode Array. Inv Ophthalmol Vis Sci Suppl. 2005;46:1488. 14. R. Singh, M. Hatton, S. Sprich, J. Loewenstein. Post Traumatic Stress Disorder and Depressive Symptoms After Open Globe Injuries. Inv Ophthalmol Vis Sci Suppl. 2005;46:5031. 15. M.D. Gingerich, D.B. Shire, J. Chen, J. Loewenstein, H.A. Shah, J. Sun, J.L. Wyatt, J.F. Rizzo. Surgical Guides for Electrode Implantation Into the Subretinal Space. Inv Ophthalmol Vis Sci Suppl. 2005;46:1494. 16. T. Fillippopoulos, J.F. Ducharme, J.I. Loewenstein, M.G. Krzytolik. Antiangiogenic Agents as an Adjunctive Treatment for Complicated Neovascular Glaucoma. Inv Ophthalmol Vis Sci Suppl. 2006;47:4476. 17. S.Chang, J.F. de Boer, M. de Bruin, A. Yun, D. Burns. Optical Frequency Domain Imaging: High Speed OCT at 1050 nm to Image Choroidal Neovascularization in Age-Related Macular Degereation Patients. Inv Ophthalmol Vis Sci Suppl. 2007;48:135.