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Problem Set for "The Origin of Chirality" by Anne‐Catherine Bédard 1. In 2008, Breslow reported that α‐methyl amino acids found on meteorites to be a plausible source of biological homochirality. These enantioenriched amino acids can transfer their chirality through copper catalysis to several proteinogenic amino acids. Propose a mechanism for this transfomation. 2. The Strecker reaction is usefull to synthesise α‐amino acid. Provide a mechanism for this transformation. 3. A chiral optical switches has been reported by Feringa in 2011. Give the structure of the product, and rationalise the relative stereochemistry of the 2 methyl groups by drawing the orbitals implicated. 4. A proposed prebiotic synthesis of purine and pyrimidines goes through the formation of this substituted imidazole. Propose a plausible mechanism for this transformation. 5. Ribose (C5H10O5) is a formal pentamer of formaldehyde (CH2O). It can be synthesise by the formose reaction. Propose a plausible mechanism for the formation of ribose.