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ECG Rounds: Pulmonary Embolism Todd Ring Jan 08/04 Case • 72 yo male with CLL • Unwell for 4-5 days with fatigue • SOB x’s 2 days, abrupt onset, progressively worse • Denies CP • Mild respiratory distress • HR 113 RR 34 BP 135/60 SaO2 85 % RA Case • CVS: pulse reg, S1 S2 (wide split) II/VI • • • • SEM Chest: Clear Ext: tender L popliteal fossa TNT: 2.8 D-Dimer: 4.79 Background • The initial electrocardiographic finding of PE first • • • • reported in 1935 was the traditional S1Q3T3 21 different ECG manifestations of PE ECG changes are best seen in those patients with massive or submassive embolization Studies have shown that 15% to 27% of ECG were normal The most common abnormalities are nonspecific ST segment-T wave changes with sinus tachycardia Pathophysiology • Clinical and ECG changes related to the response of the right ventricle to the PE • Majority of findings result from the right-sided heart strain pattern the increase in right-sided heart pressures creates an increased right ventricular afterload increased right-sided myocardial wall tension rapidly dilates, with an increase in chamber size and eventual contractile dysfunction reduction in right heart cardiac output (ie, a reduction the preload for the left ventricle) which ultimately produces a decrease in left heart cardiac output as right-sided ventricular dysfunction worsens, right ventricular infarction and circulatory collapse may occur ECG Changes • Arrhythmia (sinus tach, atrial tach, atrial fib, atrial • • • • • • flutter, PAC) Nonspecific ST segment/T wave changes T wave inversions in the right precordial leads Rightward QRS complex axis shift and other axis changes S1Q3 or S1Q3T3 pattern RBBB Acute cor pulomnale defined by S1Q3T3 pattern, right axis deviation, and RBBB “Normal ECG” • Sinus rhythm between 60 and 100 beats/min • Normal conduction, axis, and P wave, QRS complex, and ST segment/T wave morphologies • An entirely normal ECG has been found in approximately 10% to 25% of PE patients • a number of such patients will continue to manifest a normal ECG during hospitalization Sinus Tachycardia • Sinus tachycardia is the most frequent rhythm encountered on presentation to the ED in the patient with PE • The rate is usually between 100 to 125 beats/min • Likely related to the physiologic demand to increase cardiac output • as left-sided stroke volume decreases, heart rate must increase to maintain cardiac output. Sinus Tachycardia Atrial Tachyarrhythmia • Primarily atrial fibrillation and atrial flutter, also PAC’s • Likely results from atrial enlargement Atrial Fibrillation RBBB • Variable incidence reported 6 – 67 % (25 % often • • • • citied) Transient and often resolves with the restoration of normal right-sided hemodynamic parameters May persist ultimately resolving 3 months to 3 years after the index New RBBB is suggestive of PE but still nonspecific and therefore not diagnostic May also be associated with ST segment elevation and prominent, upright T waves in lead V1 and/or V2, potentially mimicking anterior or posterior infarct pattern RBBB QRS Axis Deviation • Right, left, and indeterminant QRS axis changes n reported in acute PE • Although right axis deviation (RAD) is described as the classic axis change associated with PE, left axis deviation (LAD) actually occurs more often • may be secondary to pre-existing axis deviation • in the Urokinase-Pulmonary Embolism Trial (UPET), the investigators report that LAD occurred more frequently than RAD in the PE study population however when those individuals with pre-existing cardiopulmonary disease were excluded, the incidence of LAD and RAD was equivalent P-Pulmonale • Increase in the P wave amplitude greater than 2.5 mV in lead II • Classically associated with PE, likely resulting from right atrial hypertrophy or enlargement associated with acute obstruction from clot • Reported in 2% to 30% of PE patients P-Pulmonale S1Q3T3 • Characterized by an S wave in lead I, a Q wave in lead III, and shallow T wave inversions in one or more of the inferior leads • ST segments may be slightly elevated in the inferior leads • Although this finding is consistent with right-sided cardiac changes, it remains unclear if this finding actually predicts PE • The S1Q3T3 pattern is usually short-lived, resolving within 2 weeks after PE S1Q3T3 • Mistakenly considered pathognomonic for acute PE by many clinicians • 15% to 25% of patients ultimately diagnosed with PE have this pattern • The UPET reveals that approximately 12% of patients with angiographically documented acute PE initially had the electrocardiographic S1Q3T3 • Often considered strongly suggestive for PE when, in fact, poor specificity—approximately 50%—for the diagnosis of PE S1Q3T3 S Wave Changes • S wave in lead I greater than 1.5 mm and/or an R wave-S wave ratio greater than 1 in leads I and aVl was noted in 73% of patients diagnosed with PE • A more subtle finding is a slurred S wave in leads V1 and/or V2. S Wave in V1 ST Segments • May be either depressed or elevated • Minimal ST segment depression is a common finding • More pronounced depression may also be encountered in the anterior, inferior, and lateral distributions • likely represents myocardial ischemia resulting from the physiologic strain of the PE itself • The S1Q3T3 pattern may be associated with ST segment elevation in the inferior leads. The RBBB pattern may present with ST segment elevation in the right precordial leads ST Depression V2-V6 ST Elevation V2-V5 T Wave Inversion • Anterior subepicardial ischemia caused by PE manifests as inverted T waves in the right to mid precordial leads (leads V1 to V3) • Early studies attributed this pattern to coronary insufficiency • More recent studies suggest either cathecholamine- or histamine-induced ischemia • Diffuse T wave inversion rarely is diagnostic for PE T Wave Inversion V1-V4 Evidence? • Nielsen et al. found 82% of cases of documented had electrocardiographic changes suggestive of acute right ventricular strain. These findings included: • • • • • Incomplete right bundle branch block; S1Q3T3 pattern; Q wave in lead III; Inverted T waves in leads III, V2 and V3; and/or Increase in the frontal QRS axis of >20 degrees. Nielsen et al: Changing electrocardiographic findings in pulmonary embolism in relation to vascular obstruction. Cardiol 1989;76:274-284 Evidence? • Sreeram suggests that PE should be considered when 3 or more of the following electrocardiographic changes are encountered: • Incomplete or complete RBBB; • Large S waves in leads I and a VL; • A shift in the transition zone in the precordial leads to • • • • V5 Q waves in leads III and aVF (not lead II); Right-axis deviation; A low voltage QRS complex in limb leads; and/or T wave inversion in inferior and anterior leads Sreeram et al.: Value of the 12-lead electrocardiogram at hospital admission in the diagnosis of pulmonary embolism. Am Cardiol 1994; 73:298-303 Evidence? • Petruzzeli et al. studied 21 electrocardiographic abnormalities in 245 patients with suspected PE— 60% of patients ultimately had PE. Those patients diagnosed with PE were found to manifest the following patterns more commonly: • • • • • • PR segment displacement; Delayed R wave (lead aVr); Slurred S wave (leads V1 or V2); S1Q3T3 pattern; T wave inversion (leads V1 or V2); and/or Diffuse T wave inversions Petruzzelli et al.: Routine electrocardiography in screening for pulmonary embolism. Resp 1986; 50:233-43 Evidence? • Nazeyrolas studied 70 patients with suspected PE and found only an S wave in lead I and Q wave in lead III significantly more common among those with confirmed PE Panos et al. The electrocardiographic manifestations of pulmonary embolism. Emerg Med 1988; 6:301-7 Canadian Evidence? • Rodger et al. studied the ECGs of 246 patients with suspected PE (49 with PE) comparing the frequency of 28 different ECG findings of PE • only found sinus tachycardia and incomplete RBBB significantly more common in PE patients • Sreeram's guide of 3 or more findings on the ECG had only a 26.7% sensitivity and 57.1% positive predictive value for PE • the S1Q3T3 pattern was equally prevalent among those with and without PE Rodger et al. Diagnostic value of the electrocardiogram in suspected pulmonary embolism. Am Cardiol 2000; 86:807-9 Fig. 7.