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Simulating the human respiratory pump reduces cost & mortality Department of Information Technology Conclusion: The model gives quantitative insights about the human respiratory pump. Background: Modern respirators damages the muscles responsible for our breathing. Loss of structure and function of these muscles leads to increased medical costs and in some cases patient death. The simple mass-spring model is not suitable for modeling the displacements of the diaphragm. A more advanced model is needed. Björn Karlsson [email protected] Linus Nilsson [email protected] Aims: To elaborate a model of the human respiratory pump applicable to mechanical ventilation. Advisors Elisabeth Larsson Senior lecturer at the department of Information Technology Nicola Cacciani MD specialist at the department of Neurosciences Future work: The model needs to be enhanced to provide reliable e results for respiratory and muscular research. Two major improvements are: Methods: The 3D geometries of the ribcage and diaphragm is reconstructed from computed tomography scans. The muscular part of the diaphragm is modeled using a simple mass-spring model. The diaphragm contracts (moves down) to make room for air to fill the lungs, and relaxes (moves up) to help push air out. A more advanced mathematical model for the diaphragm. Human respiratory model with lungs, diaphragm and ribcage. A description of the pressure changes in the thoracic and abdominal compartments. These displacements are formulated as a system of ODEs which are numerically solved using a symplectic Euler. Simulated diaphragm during maximum exhale and inhale Computed tomography scans are stacked together to form a volume. The volume later becomes segmented to only include the parts of interest.