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START 5 Isovolumic ventricular relaxation: as ventricles relax, pressure in ventricles falls, blood flows back into cups of semilunar valves and snaps them closed. Ventricular ejection: 4 as ventricular pressure rises and exceeds pressure in the arteries, the semilunar valves open and blood is ejected. 1 Late diastole: both sets of chambers are relaxed and ventricles fill passively. 2 Atrial systole: atrial contraction forces a small amount of additional blood into ventricles. 3 Isovolumic ventricular contraction: first phase of ventricular contraction pushes AV valves closed but does not create enough pressure to open semilunar valves. 1 EDV = end diastolic volume = volume of blood in ventricle at end of diastole ESV = end systolic volume = volume of blood in ventricle at end of systole SV = stroke volume = volume of blood ejected from heart each cycle SV = EDV - ESV 130 mL – 70 mL = 60 mL in this case. Usually 70-90mL Ejection fraction: % EDV ejected with each stroke (approx. 65%) A good index of ventricular function KEY Left ventricular pressure (mm Hg) EDV = End-diastolic volume ESV = End-systolic volume Stroke volume 120 D ESV 80 C One cardiac cycle 40 EDV B A 0 100 65 Left ventricular volume (mL) 135 2 0 Electrocardiogram (ECG) Time (msec) 200 300 400 100 P QRS complex 500 600 700 800 QRS complex Cardiac cycle T P 120 Pressure (mm Hg) 90 Aorta Dicrotic notch Left ventricular pressure 60 Left atrial 30 pressure Heart sounds Left ventricular volume (mL) Atrial systole S1 S2 135 65 Isovolumic ventricular contraction Atrial Ventricular systole systole Ventricular systole Ventricular diastole Early ventricular diastole Atrial systole Late ventricular diastole Atrial systole 3