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Trial/Pilot Event – 2017 Southeast Pennsylvania Region DESIGNER GENES RULES – C Division DESCRIPTION: Teams of 2 students will answer questions involving content knowledge and process skills in TRANSMISSION GENETICS and MOLECULAR GENETICS A TEAM OF UP TO: 2 APPROXIMATE TIME: 45 minutes THE COMPETITION: Designer Genes is a timed paper test. In lieu of stations, notebooks containing questions and images will be provided to test knowledge and critical thinking skills in the field of Genetics. Teams comprised of two students, one focusing on Transmission Genetics and the other focusing on Molecular Genetics, is suggested. Material provided can be divided up among the students on each team with all final answers recorded on answer sheets provided. Process skills may include observations, inferences, predictions, data analysis, and calculations. Topics that may be included on the exam are listed in the table below. A calculator will be permitted, but no cell phones may be used during this event. DNA & RNA Structure Control of gene expression DNA Replication Lac & Trp Operons Types of RNA Negative Feedback Gene Expression - Central Dogma Transcription Gamete Formation Gel Electrophoresis Monohybrid cross DNA Fingerprinting Genotype & Phenotype Restriction Enzymes/RFLP Dominant & Recessive Alleles Post-transcriptional Modification Chi-square Analysis Translation Mutations Mitosis & Meiosis Epistasis Genomic and cDNA Libraries Non-Mendelian Genetics Codominance Incomplete Dominance Polygenic Sex-Linked Mitochondrial DNA DNA Sequencing Plasmid Selection and Isolation Pedigree Analysis & Construction Sanger Chain Termination Polymerase Chain Reaction (PCR) Karyotype Analysis Dihybrid Cross Trihybrid Cross (probability analysis) Revised January 30, 2017 Page 1 of 1