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Homeostasis is dependent on and nervous control (b) Signaling by neurons STIMULUS Cell body of neuron Nerve impulse Axon Signal travels to a specific location. Nerve impulse Axons Response © 2016 Pearson Education, Inc. (a) Signaling by hormones STIMULUS Endocrine cell Hormones -molecules produced by endocrine glands, enter blood and have effect on target cells Hormone Signal travels everywhere. Blood vessel Response © 2016 Pearson Education, Inc. Peptide based hormones Use signal transduction pathways Utilize second messengers Steroid hormones Thyroid gland Pineal gland Thyroid hormone (T3 and T4 ) Calcitonin Melatonin Parathyroid glands Parathyroid hormone (PTH) Adrenal glands (atop kidneys) Adrenal medulla Hypothalamus Pituitary gland Posterior pituitary Oxytocin Vasopressin, also called antidiuretic hormone (ADH ) Epinephrine and norepinephrine Adrenal cortex Glucocorticoids Mineralocorticoids Ovaries (in females) Estrogens Progesterone Testes (in males) Androgens Anterior pituitary Follicle-stimulating hormone (FSH) Luteinizing hormone (LH) Thyroid-stimulating hormone (TSH) Adrenocorticotropic hormone (ACTH) Prolactin Growth hormone (GH) Melanocyte-stimulating hormone (MSH) Pancreas Insulin Glucagon © 2016 Pearson Education, Inc. Simple endocrine pathway Example: secretin signaling Low pH in duodenum STIMULUS Endocrine cell Negative feedback Hormone S cells of duodenum Secretin ( ) Circulation via blood Target cells RESPONSE © 2016 Pearson Education, Inc. Pancreatic cells Bicarbonate release Some hormones work in antagonistic pairs ex: insulin / glucagon calcitonin / PTH Neuroendocrine signaling involves the hypothalamus and the pituitary gland Simple neuroendocrine pathway Example: oxytocin signaling Suckling STIMULUS Positive feedback Neurosecretory cell Hypothalamus Posterior pituitary Hormone Blood vessel Oxytocin ( ) Circulation throughout body via blood Target cells RESPONSE © 2016 Pearson Education, Inc. Smooth muscle in mammary glands Milk release