Download Biophysics

BIOPHYSICS
I.
Name of the unit offering the course: Department of Biophysics
II.
Head of the Unit/ Course coordinator: prof. dr hab. Bronisław Grzegorzewski
III. 1st year, number of hours: 50
IV. Form of the classes: lectures: 25, tutorials: 25
V.
Form of crediting: exam
VI. Number of ECTS points: 5
VII. Topic of classes:
Semester I
Introduction. What is Biophysics. Thermodynamic system. Enthalpy. Entropy. Free energy, free enthalpy.
Chemical potential. Phenomena of mass transport. Diffusion, diffusion through the membrane, osmosis.
Electrochemical potential. Electrode potential, diffusion potential, membrane potential. Donnan
equilibrium. Nonequilibrium thermodynamics. Stationary state. Energy dissipation. Colloidal solutions.
Cell membrane, transmembrane transport. Resting potential. Electric model of cell membrane.
Action potential.
Elastic properties, Hook's law. Elements of biomechanics. Mechanism of lung ventilation.
Fluid flow, equation of continuity. Bernoulli’s principle. Viscosity. Newtonian fluid, viscoelastic fluids.
Turbulent motion of fluids. Vessel resistance. Surface tension, Laplace principal. Viscosity of blood.
Erythrocyte deformability. Erythrocyte aggregation.
Vibration, acoustic wave. Impedance. Reflection coefficient. Sound features. Equal loudness contour,
threshold of hearing, sound intensity level, loudness level.
Auditory system. Mechanical model of the middle ear. Cochlear amplifier. Loudness perception, frequency
selectivity, pitch perception. Hearing loss. Speech organs. Production of speech sounds.
Electricity and magnetism. Electric dipole. Circulatory system. Cardiac energetic. Properties of blood
vessels. Cardiac pacemaker. Cardiac action potential. Electrocardiography. Einthoven lead.
Electromagnetic wave. Optical fiber. Optical systems. Optical instruments. Microscopic techniques.
Resolving power of microscope. Light scattering. Rayleigh scattering, Raman scattering, dynamic light
scattering.
Lasers in medicine. Absorption of radiation in tissue. Penetration depth of radiation in tissue.
Optical layout of the eye, resolving power of eye, defects of vision. Vision process. Illumination units.
Nuclear forces. Radioactive decay. Ionizing radiation. Detection of nuclear radiation. Harmful effects of
ionic radiation. Radiation protection.
The influence of physical factors on organism. Mechanical, thermal, electric and magnetic factors.
Physical basis of selected therapeutic techniques: ultrasound and irradiation.
Doppler measurement of blood flow, ultrasonography, computed tomography, magnetic resonance
imaging. Single photon emission tomography SPECT, Positron emission tomography PET.
Semester I
Students perform the assigned practice, which were chosen from the following list:
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Transmembrane transport: diffusion, osmosis
The Lambert-Beer law
Fluid flow analysis
Viscosity
Electric model of cell
Spectral analysis of sound
Audiometry
Microwave analysis
Magnetic fields analysis
Elements of biomechanics
Physical basis of electrocardiography
Microscope
Optical basis of correction of vision defects
Absorption of gamma radiation.
IX. Booklist
1. Davidovits P.: Physics in Biology and Medicine, Academic Press
2. Giancoli D.C.: Physics. Principles with applications, Pearson Education, Inc.
3. .Kubisz L. (ed): Elements of medical biophysics, Poznan University of Medical Sciences
4. Kirk T.: Physics for the IB diploma, Oxford University Press
5. Tsokos K.A.: Physics for the IB diploma, Cambridge University Press