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Cardiac Physiology Class 1 Cardiac Cycle Class 2 Figure 20-17 Pressure and Volume Relationships in the Cardiac Cycle. Step 1 ONE CARDIAC CYCLE QRS complex QRS complex Electrocardiogram (ECG) T P ATRIAL ATRIAL DIASTOLE SYSTOLE VENTRICULAR DIASTOLE P ATRIAL SYSTOLE ATRIAL DIASTOLE VENTRICULAR SYSTOLE VENTRICULAR DIASTOLE 5 120 6 Aorta 90 Pressure (mm Hg) 1 2 3 60 Left ventricle 4 4 7 5 6 7 30 Left atrium 8 2 1 8 3 0 Left ventricular volume (mL) 130 3 End-diastolic volume 2 1 Stroke volume End-systolic volume 6 50 0 100 200 300 400 Time (msec) 500 600 700 800 Cardiodynamics Class 3 Figure 20-23 Factors Affecting Stroke Volume. Step 1 Factors Affecting Stroke Volume (SV) Venous return (VR) Filling time (FT) Increased by sympathetic stimulation Decreased by parasympathetic stimulation Contractility (Cont) of muscle cells Preload End-diastolic volume (EDV) End-systolic volume (ESV) STROKE VOLUME (SV) Increased by E, NE, glucagon, thyroid hormones Increased by vasoconstriction Decreased by vasodilation Afterload (AL) Figure 20-24b A Summary of the Factors Affecting Cardiac Output. Factors affecting Factors affecting heart rate (HR) stroke volume (SV) HEART RATE (HR) STROKE VOLUME (SV) = CARDIAC OUTPUT (CO) = b Factors affecting cardiac output