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CIRCULATORY SYSTEM: THE HEART SIZE, LOCATION AND ORIENTATION Mediastinum Base of the heart – Apex of the heart – HEART COVERINGS Pericardium – E Fibrous Pericardium – E Serous Pericardium – q q E Visceral layer – e Also called the outer layer of the epicardium e Composed of fibroelastic tissue that merges with the heart muscle Parietal layer – Pericardial cavity – HEART MUSCLE Composed of three layers: E Endocardium – E Myocardium – E Epicardium – 1 HEART CHAMBERS Four chambers separated by interatrial and interventricular septa or walls E E E E Right Atrium – q Entrance of: q Auricles – q Fossa ovalis – q Pectinate muscles – q Tricuspid Valves – Right Ventricle – q Exit of Pulmonary trunk – q Pulmonary semilunar valve – q Papillary muscles – q Chordae tendineae – q Trabeculae carneae – q Moderator band – Left Atrium – q Entrance of Pulmonary veins – q Bicuspid (mitral) valve – q Pectinate muscles – Left Ventricle – q Exit of aorta – q Aortic Semilunar valve – q Trabeculae carneae – q Chordae tendineae – 2 BLOOD PATHWAY THROUGH HEART Pulmonary Circulation – Systemic Circulation – Coronary Circulation E Two coronary arteries and their branches supply blood to the heart itself E Both arise from the base of the aorta and encircle the heart in the atrioventricular groove (coronary sulcus) E Effective when the heart is not contracting E Right Coronary Artery – E E q Marginal artery – q Posterior interventricular artery – q Sinoatrial nodal artery – q Atrioventricular nodal artery – Left Coronary Artery – q Anterior interventricular artery – q Circumflex artery – Coronary Veins – q Coronary sinus – e Three tributaries: C Small, middle and great cardiac veins – q Anterior cardiac veins – CARDIAC HISTOLOGY Cardiac Muscle – E Intercalated discs – 3 CARDIAC CONDUCTION SYSTEM Nodal System – E Autorhythmic cells – q q q q q Sequence of Excitation – E Sinoatrial (SA) Node – q q q q q E Atrioventricular (AV) Node – q q q E Atrioventricular Bundle (Bundle of His) – q E Bundle Branches – q q E Purkinje Fibers – q q 4 q Extrinsic Innervation – E E E E Stimulation by sympathetic neurons – q q E Inhibition by parasympathetic neurons – q q q CARDIAC CYCLE Two Phases: E E Systole Phase – q Atrial systole (0.1 sec) – q Ventricular systole (0.3 sec) – Diastole Phase – q Ventricular diastole – 5 ELECTRICAL EVENTS (as recorded from an ECG) Consists of three waves: E P wave – E QRS complex – E T wave – HEART SOUNDS Lub-dub – Pause – CARDIAC OUTPUT – Starling’s Law of the Heart – HEART RATE REGULATION Nervous Regulation – E Cardiac inhibitory center – q E Vagus nerve – Cardiac accelerator center – Hormonal Regulation E Accelerators – 6 Body Temperature – Baroreceptors (pressoreceptors) – E Carotid sinus & Aortic arch – E Bainbridge (atrial) baroreceptors – HEART AND CIRCULATORY DISORDERS Tachycardia – Bradycardia – Myocardial infarction – Arrhythmia – Fibrillation – Angina pectoris – Pericarditis – Congestive heart failure – Atherosclerosis – Ischemic heart disease – Heart murmur – 7