Download Images showing each mode

Cover Page
VisualSonics is the leading developer of high-resolution in vivo micro imaging systems devised
specifically for non-invasive small animal research. High-resolution imaging allows the small
animal researcher to derive results in ways that were previously possible to imagine, but
extremely difficult to achieve. The Vevo 770 enables in vivo assessment of anatomical
structures and hemodynamic function in longitudinal studies of small animals.
VisualSonics’ Vevo 770 offers spatial resolution down to 30 microns; in fact the highest
resolution available in real-time today. And the system is non-invasive, which allows
longitudinal studies and fewer mice required. VisualSonics technology provides scientific
professionals with a simple method for efficiently viewing extremely small physiological
structures and for imaging living tissue and blood flow with near-microscopic resolution. The
Vevo 770 has evolved from the outset as a tool designed to be utilized by researchers.
Because the mouse is the preferred model for phenotypic study, genetic research and drug
applications, the Vevo 770 has been developed specifically for mice. Researchers should note
however, that the equipment and technology is readily transferable and adaptable to other
small animal models such as the rat.
The Vevo 770 is able to deliver the small animal researcher:
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Non-invasive, in vivo visualization of embryonic (E5.5) through to adult mice — in realtime.
Ability to perform longitudinal studies of disease progression and regression in individual
subjects.
Image resolution of anatomical and physiological structures of down to 30 microns.
Ability to visualize image-guided needle injection and extraction.
Microcirculatory and cardiovascular blood flow assessment.
High throughput via user-friendly equipment and research-driven interface.
Open architecture allowing comprehensive measurement and annotations and offline data
analysis.
Export of all image and analysis data in PC and Macintosh-compatible formats.
Link to VisualSonics
Use this to link to VisualSonics’ website:
www.visualsonics.com
Here is a button that can be used to for the link:
Images of Vevo, Railsystem & Anesthesia system
Vevo 770 Cart
Anesthesia System
Railsystem
Images showing each mode
B-Mode
Acquire two-dimensional images and film loops (or CineLoops) of still and dynamic
mouse anatomy. Able to guide needle-based procedures with real-time imaging, for
the injection of chemicals, retroviral DNA, or other biochemical compounds into
tissue regions that can be seen clearly within the image area.
Extraction of fluid and/or cells under image guidance for biopsy, bio-assays and
analysis is also possible. Export still images, export video loops, measure lengths,
areas and circumferences of ellipses and user-defined polygons.
M-Mode
Acquire quantifiable images to characterize rapidly moving cardiac anatomy, by
selecting a line of the B-Mode image, and observing it as a function of time, enabling
measurements of speed and acceleration.
Imaging the left ventricle, for example, the Vevo 770 pulses rapidly (up to 1,000
times per second) and its M-Mode displays a representation of the motion of the
heart wall, the thickness of the heart wall and the diameter of the chamber.
Pulsed Wave Doppler
Characterize and measure physiology by using the PW Doppler Mode to visually and
audibly analyze the velocity of flow in vessels. The Doppler Sample Volume, a region
of interest, is guided with the Vevo 770's high-resolution imaging.
The sample volume size may be set at levels sensitive enough to discriminate flow
from individual arterioles and venules or measure flows in larger vessels. Record
visualizations and audio output in standard PC or Macintosh-compatible formats to
playback in multimedia presentations.
Images
Doppler measurement of pulmonary artery peak velocity
PW Doppler of Pulmonary Artery Outflow in Adult Mouse
Guided Injection into Myocardium
Cine Loop of Image-Guided Injection procedure with needle penetrating into the
Myocardium in Adult Mouse
PW Doppler of Mitral Valve
PW Doppler of Mitral Valve in Adult Mouse
EKV image - Quantify Cardiac wall motion:
Mitral Valve and Pulmonary Valve in Adult Mouse using EKV™ (Also See
CineLoop: Mitral Valve EKV) (Included .avi and .swf file)
Injection into embryonic:
Injection into E11.5 Hindbrain
Guided Injection into Hindbrain of embryonic day 11.5 mouse
Visualization of Injection into Day 3 Chick Embryo
Cardiac Development:
Day 3 Chick Embryo Heart
B-Mode image of Day 3 Chick Embryo Heart
Intra Cardiac Flow in Day 4 Chick Embryo
PW Doppler image of Intra Cardiac Flow in Day 4 Chick Embryo
Embryology Research
E10.5 Mouse Showing Umbilical Cord, Amniotic Wall, and Limb Buds
Visualization of Plaque
Plaque Build-up in Carotid Arteries in Adult Mouse
Image sequence courtesy of Gan et al, University of Gothenburg, Sweden, 2004
Left Common Carotid Artery Doppler
Image by Zhou, YQ, MiCe Mouse Imaging Centre
Abdominal Aorta and Pericardial Effusion in the Rat
Four Chamber View of Interatrial Septum in E13 Mouse
Carotid Branches
Carotid Branches in Adult Mouse
(Also See CineLoop: Carotid Bifurcation) (Included .avi and .swf file)
Rats
Brain Ventricles
Embryonic Middle Cerebral Artery
3D Quantification, Blood flow & Vascularity
3D Scan through kidney tumor
A scan through a segmented Kidney Tumor in an adult mouse
2D Power Doppler of Melanoma
2D Power Doppler to visualize perfusion in Melanoma in Adult Mouse
Changes in Flow State in Prostate Tumor Line
A three-image sequence showing changes in Vasculature in Prostate Cell Line in
subcutaneous Tumor in Adult Mice. The first image shows vascularity in a tumor with
no intervention. The middle image shows a tumor post-introduction of radiation and
the third image shows a tumor with reduced vascularity post introduction of radiation
and drug.
Image Credits: Images courtesy of Czarnota, G. Princess Margaret Hospital, Toronto, 2004
3D Power Doppler of Adult Mouse Testicle
Static image using 3D Power Doppler of perfusion in Adult Mouse Testicle. The image
of the testicle was constructed with multiple 2D slices to create the 3D volumetric
image.
Vascularity in Melanoma in Adult Mouse
Pages from Brochure:
Analytic Software
RMV Selection & Applications