Download Investigation of modulation of Blood Retinal Barrier Tight

Research Student Project
Supervisor name & contact details:
Brenda Brankin
School of Biological Sciences
[email protected]
Research Centre Name and Website (if
applicable)
Dit.ie/eshi
Please indicate if the intention is to transfer
from the Masters programme to the PhD
programme (if applicable)
Please indicate if the project is suitable for a
self-funded student
No
Funding Agency
Scholarship Details
Subject Area
Biological Sciences
Title of the Project
Investigation of modulation of Blood Retinal
Barrier Tight Junction Permeability
Project Description (max 300 words)
The Blood Retinal Barrier (BRB) comprises an inner BRB and an outer BRB. The BRB is
compromised in several ocular diseases including diabetic retinopathy. High levels of vascular
endothelial growth factor (VEGF) are present in the vitreous in diabetic retinopathy, and VEGF
affects endothelial cell tight junctions, and increases permeability. We have found the drug
endostatin antagonises VEGF-mediated vascular permeability. This project will determine effects
of anti-VEGF agents and cytokine inhibitors on BRB permeability and tight junction expression.
The effects of growth factors, conditioned media or vitreous on BRB properties will be studied.
This proposal will advance our investigations into the role of endogenous and exogenous derived
vitreal proteins in the pathogenesis of ocular diseases. Gaining an understanding of the
mechanism of these agents on vasopermeability and tight junction expression will enable the
development of essential new therapeutic options in ocular diseases.
Please indicate the student requirements for this project
Applicants should have a good primary degree (First or second class honours) in an appropriate
discipline (Biological Sciences, Biomedical Science, Biochemistry, Pharmacology).
Deadline to submit applications (only for
funded projects)