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UCSI University
Faculty of Pharmaceutical Sciences
Full Name
Associate Professor Dr. Chin Jin Han
Current Position
Head of Postgraduate and Research
Academic Qualifications
PhD, BSc. (Hons)
Professional Bodies
Member of Malaysia Society of Applied Biology
Member of Malaysian Society of Pharmacology & Physiology
Member of Malaysian Society of Natural Product
Research (any on-going / completed research project)
Completed Projects:
1. Toxicity Study and Drug Metabolism of Misai Kucing
(Orthosiphon stamineus) in rats.
2. Toxicity study of Averrhoa carambola (star fruit) in
Sprague Dawley rats.
3. FTIR profile and antioxidant studies of botanical/ dietary
supplements
4. The effect of Averrhoa carambola (star fruit) on
acetylcholinesterase in Sprague Dawley rats.
5. Evaluation of the toxic effect of Vinca rosea leave extract
in rats.
6. Evaluation of the Toxic Effect of Strobilanthes crispus
leaf extract in rats.
On-going Projects:
1. Evaluation of the toxic effect of Clinacanthus nutans
leaves extract in rats
2. Effect of the Clinacanthus nutans leaves extract on
acetylcholinesterase activity in mice.
3. Phytochemical analysis and toxicity study of Vernonia
amygdalina
4. Effect of several Local medicinal plant extracts on Phase I
and II Drug Metabolism Enzymes in Human Liver
Microsomes.
5. Phytochemical analysis, preliminary screening of anticancer activity and oral toxicity study of Clinacanthus
UCSI University
Kuala Lumpur Campus
No. 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, W. P. Kuala Lumpur. Tel: 03-91018880 Fax: 03-91023606 Website: www.ucsi.edu.my
nutans leaves extract
Publications
Book Chapters
Chin JH, Hussin AH. Orthosiphon stamineus Modulates
Acetaminophen-Induced Changes in Serum Hepatic Markers,
Hepatocytes Viability and Glutathione-s-transferase Activity
in Rats. In: Gupta VK, Singh GD, Singh S, Kaul A, editors.
Medicinal Plants: Phytochemistry, Pharmacology and
Therapeutics. New Delhi: Daya Publishing House; 2012; 2:
405-12.
Chin JH, Hussin AH. Safety assessment of Orthosiphon
stamineus Benth methanol leaf extract: drug interaction and
oral toxicity study in rats. In: Gupta VK, editor. Medicinal
Plants. New Delhi: M/S Daya
Publishing
House;
2010; 1: 228-37.
Chin JH, Akowuah GA, Hussin AH, Ismail Z, Yam MF,
Ismail S. Toxicity and in-vivo antioxidant effect of
Orthosiphon stamineus leaf extracts in rats. In: Singh VK,
Govil JN, editors. Recent Progress in Medicinal Plants:
Phytopharmacology and Therapeutic Values III. Houston:
Studium Press LLC; 2008; 21: 137-46.
Journals
P’ng XW, Akowuah GA, Chin JH. Evaluation of the Subacute Oral Toxic Effect of Methanol Extract of Clinacanthus
nutans Leaves in Rats. Journal of Acute Disease. 2012
(Accepted).
Lim KT, Lim V, Chin JH. Sub-acute Oral Toxicity of
Ethanolic Leaves Extracts of Strobilanthes crispus in Rats.
Asian Pacific Journal of Tropical Disease. 2012 (Accepted).
Kevin LYW, Hussin AH, Zhari I, Chin JH. Sub-acute oral
toxicity study of methanol leaves extract of Catharanthus
roseus in rats. Journal of Acute Disease. 2012; 1(1):38-41.
P’ng XW, Akowuah GA, Chin JH. Acute oral toxicity study
of Clinacanthus nutans in mice. International Journal of
Pharmaceutical Sciences and Research. 2012; 3(11):4202-5.
Teh CC, Khoo ZY, Shamala F, Chin JH. Averrhoa
carambola (star fruit) induces hepatic alkaline phosphatase
activity in rats. International Journal of Biomedical and
UCSI University
Kuala Lumpur Campus
No. 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, W. P. Kuala Lumpur. Tel: 03-91018880 Fax: 03-91023606 Website: www.ucsi.edu.my
Advance Research. 2011; 1(5):135-40.
Chin JH, Hussin AH. Sub-Acute Oral Toxicity Study of
Orthosiphon stamineus (Lamiaceae) in streptozotocin-induced
Diabetic Rats. Pharmacologyonline. 2011; 1:1014-23.
Chin JH, Hussin AH. Orthosiphon stamineus Increases
Metabolism of Aminopyrine in Female Rat Hepatocytes by
Inhibiting Protein Kinase A. International Journal of
Pharmaceutical Sciences and Research. 2011; 2(7): 1777-80.
Khoo ZY, Teh CC, Rao NK, Chin JH. Evaluation of the toxic
effect of star fruit on serum biochemical parameters in rats.
Pharmacognosy Magazine. 2010; 6(22): 120-4.
Teh CC, Khoo ZY, Rao NK, Chin JH. Acetycholinesterase
inhibitory activity of star fruit and its effect of serum lipid
profiles in rats. International Food Research Journal. 2010;
17: 984-94.
Chin JH, Ismail S, Hussin AH. Effect of Orthosiphon
stamineus leaf extract on hepatic cytochrome P450, UGT and
GST activity in STZ-induced diabetic rats. Journal of
Advancement of Science & Art. 2009; 1 (1): 1-8.
Chin JH, Mahfoudh M, Abas HH. Interactions of
Orthosiphon stamineus and Morinda citrifolia with hepatic
aminopyrine metabolism
by
CYP3A
in
rats.
Pharmacognosy Magazine. 2009; 17 (4): 55-60.
Akowuah, GA, Mariam, A, Chin JH. The effect of extraction
temperature on total phenols and antioxidant activity of
Gynura procumbens leaf. Pharmacognosy Magazine. 2009;
17 (4): 81-85.
Chin JH, Hussin AH, Ismail S. Anti-hepatotoxicity Effect of
Orthosiphon stamineus Benth against Acetaminopheninduced Liver Injury in Rats by Enhancing Hepatic GST
Activity. Pharmacognosy
Research. 2009; 1 (2): 53-58.
Chin JH, Hussin AH, Ismail S. Hepatoprotective Effect of
Orthosiphon stamineus Benth. Against Acetaminophen
Intoxication in Rats. Journal of Natural Remedies. 2009; 9(2):
177-184.
Chin JH, Hussin AH, Ismail S. Effect of methanol leaf
extract of Orthosiphon stamineus Benth. on hepatic drug
UCSI University
Kuala Lumpur Campus
No. 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, W. P. Kuala Lumpur. Tel: 03-91018880 Fax: 03-91023606 Website: www.ucsi.edu.my
metabolism enzymes in Sprague Dawley rats. Journal of
Bioscience. 2008; 19 (1):23-33.
Chin JH, Ismail S, Hussin AH. Induction of hepatic
glutathione-S-transferase activity by Orthosiphon stamineus,
Benth in STZ-induced diabetic rats. Malaysian Journal of
Pharmaceutical Sciences. 2008; 6(1):59-68.
Chin JH, Hussin AH, Ismail S. Toxicity study of Orthosiphon
stamineus on Sprague Dawley rats. Tropical Biomedicine.
2008; 25(1): 9-16.
Chin JH, Hussin AH. Effect of the Orthosiphon stamineus,
Benth on aminopyrine metabolism in rat hepatocytes.
Malaysian Journal of Pharmaceutical Sciences. 2007; 5(1):
25-32.
Chin JH, Ismail S, Hussin AH, Ismail Z. pNP UDPglucurosyltransferase activity in liver microsomes from
Sprague Dawley rats fed with methanol extract of Misai
Kucing (Orthosiphon stamineus). Malaysia Journal of
Science. 2005; 24: 235-237.
Conferences/Seminar
Chin JH, Hussin AH, Ismail Z. In-vitro study on the Influence
of Orthosiphon stamineus (Misai Kucing) on the Aminopyrine
Metabolism in the Normal Rat Liver. MPS Pharmacy
Scientific Conference. Penang; 2002 Nov; Penang.
Chin JH, Hussin AH. The in-vivo (Acute) Effect of
Orthosiphon stamineus (Misai Kucing) on Aminopyrine
Metabolism in Normal and STZ-induced Diabetic Sprague
Dawley Rat Liver. 18th Scientific Meeting of the Malaysian
Society of Pharmacology and Physiology
(MSPP); 2003
Apr; Kuala Lumpur.
Chin JH, Ismail S, Hussin AH, Ismail Z. The effect of Misai
Kucing (Orthosiphon stamineus) Extract on Glutathione-Stransferase (GST) Activity. MPS Pharmacy Scientific
Conference; 2003 Oct; Selangor.
Chin JH, Ismail S, Hussin AH, Ismail Z. p-Nitrophenol UDPGlucuronosyltransferase Activity in Liver Microsome from
Sprague Dawley Rats fed with Methanol Extract of
Orthosiphon stamineus (Misai Kucing). 19th Annual Seminar
& Workshop of the Malaysian Natural Products Society; 2003
UCSI University
Kuala Lumpur Campus
No. 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, W. P. Kuala Lumpur. Tel: 03-91018880 Fax: 03-91023606 Website: www.ucsi.edu.my
Oct; Kuala Lumpur.
Chin JH, Hussin AH, Ismail S. In-vivo (subchronic) effect of
methanolic extract of Orthosiphon stamineus (Misai Kucing)
on Aminopyrine N-demethylase and Glutathione-S-transferase
activity in Rat Liver. Proceeding of 14th National
Biotechnology Seminar; 2003 Dec; Penang.
Chin JH, Hussin AH. Molecular Mechanism Elucidation in
Herb-drug Interaction Study: The Effect of Methanol Extract
of Misai Kucing (Orthosiphon stamineus) on Aminopyrine
Metabolism in Rat Liver. Proceeding of 2nd Life Sciences
Postgraduate Conference; 2004 Apr; Penang.
Chin JH, Ismail S, Hussin AH. In-vitro Study on the
Influence of Orthosiphon stamineus on Liver Drug
Metabolising Enzymes in Streptozotocin-induced Diabetic
Rat. 19th Scientific Meeting Malaysian Society of
Pharmacology and Physiology; 2004 May; Kuala Lumpur.
Chin JH, Hussin AH. Possible Effect of Misai Kucing
(Orthosiphon stamineus) on Phosphotidyl-Inositol Pathway in
Affecting Aminopyrine Metabolism in Old Male Rat
Hepatocytes. Seminar on Medicinal & Aromatic Plants; 2004
July; Kuala Lumpur.
Chin JH, Ismail S, Hussin AH. Comparison of
Spectrophotometric vs HPLC Method for the Determination of
UDP-glucuronosyltransferase Activity in Rat Liver
Microsomes. Proceeding of 2nd Life Sciences Postgraduate
Conference; 2004 Apr; Penang.
Chin JH, Hussin AH. Hepatoprotective effect of Misai
Kucing (Orthosiphon stamineus) on Sprague Dawley rats. 4th
UiTM-MPS Pharmacy Scientific Conference; 2004 Aug;
Kuala Lumpur.
Chin JH, Hussin AH. Subacute Toxicity Studies of the Misai
Kucing on Sprague Dawley rats. 20th Scientific Meeting of the
Malaysian Society of Pharmacology and Physiology (MSPP);
2005 Apr; Penang.
Hussin AH, Chin JH. Hepatic drug metabolism: Interaction
between Orthosiphon stamineus, Benth. (Misai Kucing) and
aminopyrine in diabetic female Sprague-Dawley rats. 9th
Commonwealth Pharmaceutical Association Conference; 2007
Aug; Kuala Lumpur.
UCSI University
Kuala Lumpur Campus
No. 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, W. P. Kuala Lumpur. Tel: 03-91018880 Fax: 03-91023606 Website: www.ucsi.edu.my
Chin JH, Hussin AH. Study on the Herb-drug Interaction of
Orthosiphon stamineus with Aminopyrine in Rats. 4th Asian
Association of Schools of Pharmacy-9th Malaysian
Pharmaceutical Society Pharmacy Scientific Conferences;
2009 June; Penang.
Chin JH, Lim V, Lim KT. Evaluation of Toxic Effect of
Strobilanthes crispus Ethanol Leaves Extract in Rats.
International Conference on Natural Products; 2011 Nov;
Putrajaya
Vun VK, Akowuah GA, Chin JH. Fourier Transform Infra-red
(FTIR) Profile and Free Radical Scavenging Activities of
Selected Seeds. International Conference on Natural Products;
2011 Nov; Putrajaya.
Chin JH, Kevin LYW, Hussin AH, Zhari I. Sub-acute Oral
Toxicity of Methanol Leaves Extract of Catharanthus roseus in
Rats. Malaysian Society of Pharmacology and Physiology
(MSPP) Conference; 2012 May; Penang
UCSI University
Kuala Lumpur Campus
No. 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, W. P. Kuala Lumpur. Tel: 03-91018880 Fax: 03-91023606 Website: www.ucsi.edu.my