Download morphogens-nodal

Morphogens signaling molecule gradients
Rogers and Schier, 2011
Signaling from the YSL
Nodal mutant
wild-type
sqt;cyc -/No endoderm
No head & trunk mesoderm
Feldman et al., 1998
Nodal pathway
Shen, 2007
Cell movements observed in section
Keller et al., 2008
Normally ~1550 cells internalize; in MZoep ~60 internalize
Nodal induces involuting mesoderm
Xu et al., 2014
The Organizer
Shield
(Organizer)
Organizer: transplantation generating a second axis
D
C
B
Fauny et al., 2009
Morphogens signaling molecule gradients
Xu et al., 2014
Xu et al., 2014
Nodal induces symmetric domains
Xu et al., 2014
Nodal + BMP induces asymmetric domains
Nodal
Nodal + BMP
Xu et al., 2014
Nodal
Nodal + BMP
Xu et al., 2014
Muller et al., 2012
Muller et al., 2012
Muller et al., 2012
Muller et al., 2012
Muller et al., 2012
Muller et al., 2012
References
Balaskas N, Ribeiro A, Panovska J, Dessaud E, Sasai N, Page KM, Briscoe J, Ribes V. (2012). Gene regulatory logic for
reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell. 148:273-84.
Fauny JD, Thisse B, Thisse C. (2009). The entire zebrafish blastula-gastrula margin acts as an organizer dependent on
the ratio of Nodal to BMP activity. Development. 136:3811-9.
Kondo S, Miura T. (2010). Reaction-diffusion model as a framework for understanding biological pattern formation.
Science. 329:1616-20.
Müller P, Rogers KW, Jordan BM, Lee JS, Robson D, Ramanathan S, Schier AF. (2012). Differential diffusivity of Nodal
and Lefty underlies a reaction-diffusion patterning system. Science. 336:721-4.
Müller P, Rogers KW, Yu SR, Brand M, Schier AF. (2013). Morphogen transport. Development. 140:1621-38.
Rogers KW, Schier AF. (2011). Morphogen gradients: from generation to interpretation. Annu Rev Cell Dev Biol. 27:377407.
Schier AF. (2009). Nodal morphogens. Cold Spring Harb Perspect Biol. 1:a003459.
Shen MM (2007). Nodal signaling: developmental roles and regulation. Development. 134:1023-34.
Xu PF, Houssin N, Ferri-Lagneau KF, Thisse B, Thisse C. (2014). Construction of a vertebrate embryo from two
opposing morphogen gradients. Science. 344:87-9.