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Ascending (Sensory) Pathways Pathway/Tract Sensation First Order Neuron Second Order Neuron Third Order Neuron POSTERIOR COLUMN PATHWAY Fasciculus gracilis Fasciculus cuneatus SPINOTHALAMIC PATHWAY Lateral spinothalamic tracts Anterior spinothalamic tracts SPINOCEREBELLAR PATHWAY Posterior spinothalamic tract Anterior spinothalamic tract Final Destination Site of Crossover (Decussation) Descending (Motor) Pathways Tract Location of Upper Motor Neurons Destination CORTICOSPINAL PATHWAY Corticobulbar tracts Lateral corticospinal tracts Anterior corticospinal tracts MEDIAL PATHWAY Vestibulospinal tracts Tectospinal tracts Reticulospinal tracts LATERAL PATHWAY Rubrospinal tract Site of Crossover Action Ascending (Sensory) Pathways Pathway/Tract Sensation First Order Neuron Second Order Neuron Third Order Neuron Final Destination Site of Crossover (Decussation) Fasciculus gracilis Proprioception and fine touch, vibration from inferior half of body Proprioception and fine touch, vibration from superior half of body Dorsal root ganglia of inferior half of body Nucleus gracilis of medulla oblongata Ventral nuclei of thalamus Primary sensory cortex on side opposite stimulus Axons of 2nd order neuron before entering medial meniscus Dorsal root ganglia of superior half of body Nucleus gracilis of medulla oblongata Ventral nuclei of thalamus Primary sensory cortex on side opposite stimulus Axons of 2nd order neuron before entering medial meniscus POSTERIOR COLUMN PATHWAY Fasciculus cuneatus SPINOTHALAMIC PATHWAY Lateral spinothalamic tracts Anterior spinothalamic tracts Pain and temperature Dorsal root ganglia Interneurons in posterior gray horn Ventral nuclei of thalamus Primary sensory cortex on side opposite stimulus Axons of 2nd order neurons at level of entry Crude touch and pressure Dorsal root ganglia Interneurons in posterior gray horn Ventral nuclei of thalamus Primary sensory cortex on side opposite stimulus Axons of 2nd order neurons at level of entry SPINOCEREBELLAR PATHWAY Posterior spinothalamic tract Anterior spinothalamic tract Proprioception Dorsal root ganglia Interneurons in posterior gray horn Not applicable Cerebellar cortex on side of stimulus Not applicable Proprioception Dorsal root ganglia Interneurons in same spinal section Not applicable Cerebellar cortex on side and opposite side of stimulus Axons of most 2nd order neurons before entering tract, some recross at cerebellum Descending (Motor) Pathways Tract Location of Upper Motor Neurons Destination Site of Crossover Action CORTICOSPINAL PATHWAY Corticobulbar tracts Primary motor cortex Lateral corticospinal tracts Primary motor cortex Anterior corticospinal tracts Primary motor cortex Lower motor neurons of cranial nerve nuclei in brain stem Lower motor neurons of anterior gray horns of spinal cord Lower motor neurons of anterior gray horns of spinal cord Brain stem Conscious motor control of skeletal muscles Pyramids of medulla oblongata Conscious motor control of skeletal muscles Level of lower motor neuron Conscious motor control of skeletal muscles None Subconscious regulation of balance and muscle tone Brainstem Subconscious regulation of eye, head, neck, and upper limb position Subconscious regulation of reflex activity MEDIAL PATHWAY Vestibulospinal tracts Tectospinal tracts Reticulospinal tracts Vestibular nuclei Tectum Reticular formation Lower motor neurons of anterior gray horns of spinal cord Lower motor neurons of anterior gray horns of cervical spinal cord Lower motor neurons of anterior gray horns of spinal cord None LATERAL PATHWAY Rubrospinal tract Red nuclei of mesencephalon Lower motor neurons of anterior gray horns of spinal cord Brainstem Subconscious regulation of upper limb muscle tone and development