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CURRICULUM VITAE – MICHAEL J. WELCH, Ph.D. Personal Information: a. Sex: Male b. Birth date: 28 June 1939 c. Birthplace: Stoke-on-Trent, England Citizenship: USA__X__ Other____ Addresses and Telephone Numbers: Office: Division of Radiological Sciences Department of Radiology Washington University School of Medicine 510 South Kingshighway Blvd. Campus Box 8225 St. Louis, Missouri 63110 USA 314-362-8436 314-362-8399 fax Home: 312 N. Meramec #200 St. Louis, MO 63105 314-727-1550 Present Positions: Professor of Radiology Professor of Chemistry Professor of Developmental Biology Professor of Biomedical Engineering Washington University in St. Louis Education: Undergraduate: B.A. Degree in Natural Sciences – Cambridge University, England, 1961 Graduate: M.A. Degree in Natural Sciences – Cambridge University, England, 1964 Ph.D. Degree Chemistry – University of London, England, 1965 1 Academic Position/Employment: 9/62 - 8/65 Graduate Student Queen Mary College Department of Chemistry University of London London, England 9/65 - 9/67 Research Associate Brookhaven National Laboratory Upton, New York 9/67 - 7/70 Assistant Professor of Radiation Chemistry The Edward Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, Missouri 9/69 - 1/71 Assistant Professor of Chemistry Department of Chemistry Washington University St. Louis, Missouri 7/70 - 7/74 Associate Professor of Radiation Chemistry The Edward Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, Missouri 1/71 - 7/75 Associate Professor of Chemistry Department of Chemistry Washington University St. Louis, Missouri 7/75 - 7/78 Adjunct Professor Department of Chemistry Washington University St. Louis, Missouri 7/74 - 1991 Professor of Radiation Chemistry The Edward Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, Missouri 7/78 – present Professor of Chemistry Department of Chemistry Washington University St. Louis, Missouri 7/90 - 12/94 Director, Division of Radiation Sciences The Edward Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, Missouri 2 7/91 – present Professor of Radiology The Edward Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, Missouri 1/93 – present Professor of Developmental Biology Department of Developmental Biology Washington University School of Medicine St. Louis, Missouri 12/94 – 06/07 Co-Director, Division of Radiological Sciences The Edward Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis, Missouri 06/00 – present Professor of Biomedical Engineering Department of Biomedical Engineering Washington University in St. Louis St. Louis, Missouri Siteman Cancer Center Activities Member: 1997 – present Head, Oncological Imaging Research Program: 2000 – present Member, Senior Leadership Committee: 2000 – present Co-Director, Small Animal Imaging Core: 2000 – present Honors and Awards: Open Scholarship to St. Catharine’s College Cambridge University, England: 1958 - 1961 Japanese Society for the Promotion of Science Visiting Scholar: 1980. American Chemical Society St. Louis Award, for outstanding contributions to the chemical profession: 1988 National Award for Nuclear Chemistry, for contributions in Fundamental and Applied Nuclear Chemistry: 1990 Midwest Award, for outstanding achievements by a chemist in the Midwest Region: 1991 Society of Nuclear Medicine Paul C. Aebersold Award, for outstanding achievement in Basic Science Applied to Nuclear Medicine: 1980 Berson-Yalow Award, for an outstanding contribution using the principle of Radioimmunoassay: 1988 Berson-Yalow Award, for an outstanding contribution using the principle of Radioimmunoassay: 1990 Georg Charles de Hevesy Nuclear Medicine Pioneer Award, for distinguished contributions to Nuclear Medicine: 1992 Cassen Prize: 2004 The Institute of Medicine Elected Member: 1999 American College of Radiology Honorary Fellow: 2004 International Isotope Society Melvin Calvin Award, for outstanding contributions to the field of isotopes: 2006 3 Society of Molecular Imaging Molecular Imaging Achievement Award, 2007 Society of Nuclear Medicine Michael J. Welch Award (presented annually)-In recognition of his outstanding contributions to the field of Radiopharmaceutical Chemistry, 2008 Academy of Molecular Imaging Distinguished Basic Scientist recipient, 2008 Washington University School of Medicine Second Century Award, 2008 Distinguished Faculty Award for Outstanding Researcher, 2011 Radiological Society of North America Eugene P. Prendegrass New Horizons Lecturer 2008 (Nanotechnology in the future of imaging: Prospects and pitfalls) Washington University School of Medicine Distinguished Faculty Awards; Distinguished Investigator Award, 2011 Professional Societies and Organizations: American Chemical Society Member, Division of Nuclear Chemistry - Technology The Royal Society of Chemistry (London) The Radiation Research Society Sigma Xi International Symposia on Radiopharmaceutical Chemistry Member, International Founding and Organizing Committee: 1978-Present The Society of Nuclear Medicine Program Committee Member: 1969, 1972, 1975, 1983 President-Elect, Missouri Valley Chapter: 1975 - 1977 President, Missouri Valley Chapter: 1977 - 1979 Program Committee Subchairman: 1978, 1979 Member, Board of Directors, Radiopharmaceutical Science Council: 1977 - 1979 Member, Board of Trustees: 1980 - 1990 President, Radiopharmaceutical Science Council: 1980 - 1981 Program Committee Vice-Chairman: 1981, 1984 President-Elect: 1983 - 1984 President: 1984 Chairman, Awards Committee: 1986 - 1988 General Program Chairman: 1988 – 1991 Society of Radiopharmaceutical Chemistry and Biology President: 2001 – 2003 Member, Executive Committee: 2003 – 2006 National Academy of Sciences Member, Subcommittee on Nuclear and Radiochemistry: 1980 - 1982. Member, Committee on Nuclear and Radiochemistry: 1983 - 1986 Co-Chairman, Workshop on Training Requirements for Chemists in Nuclear Medicine, Nuclear Industry and Related Areas: 1988 Diagnostic Radiology Study Section, NIH, Member: July 1986–1991 Chairman: July 1989-1991 The Whitaker Foundation Member, Scientific Advisory Committee: August 1995–2004 Institute of Medicine Member, Clinical Research Roundtable: 2000 - 2004 Member, Board on Health Science Policy: 2003 - 2009 Canada Research Chairs Program 4 Member, Review Committee: September 2000 – present NCI Program Project Review Group Member, Subcommittee E on Cancer Epidemiology, Prevention and Control: 2002-2008 Editorial Activities: Associate Editor, Journal of Computed Tomography: 1978 -1984 Editorial Board, Journal of Nuclear Medicine: 1982 -1988, 2002 - present Associate Editor, Journal of Nuclear Medicine: 1988 – 2002 Past Graduate Students – present positions Berridge, Marc, Ph.D. Professor Department of Radiology University of Arkansas Medical School 4301 W. Markham St. Little Rock, AR 72205 Frost, John J., M.D., Ph.D. Professor Department of Radiology Johns Hopkins Medical Institute 600 N. Wolfe Street Baltimore, MD 21287-2179 Bonasera, Thomas A. Ph.D. Manager, PET and Imaging Center Radiochemistry Glaxo Smith Kline Greenford Middlesex, England UB6 OHE Hennkens, Heather, Ph.D. Staff Scientist Analytical Bio-Chemistry Laboratories, Inc. 7200 E ABC Lane Columbia, MO 65211 Breaux (Wiegers), Carol, Ph.D. Department of Chemistry College of the Ozarks Branson, MO Jiang, W. Victor, Ph.D. Director of Radioimmunoassay Research Kaiser Hospitals 4131 Geary Blvd. San Francisco, CA 94118 Chesis, Paul, M.D., Ph.D. Radiologist Deweese Radiological Group, Inc. 5700 Broadmoor, Suite 900 Mission, KS 66202 Jones-Wilson, Michelle, Ph.D. Associate Professor Department of Chemistry East Stroudsburg University 200 Prospect St. East Stroudsburg, PA 18301 Dischino, Douglas, Ph.D. Senior Research Chemist Bristol-Myers/Squibb P.O. Box 5100, Department 403 Wallingford, CT 06492 Knight, Linda C., Ph.D. Professor Department of Radiology Temple University 3401 North Broad Street Philadelphia, PA 19140 Downer, Joanna B., PhD Senior Associate Duke University Medical Center 604 Macon Drive Wilmington, NC 28412 Loberg, Michael D., Ph.D. Chief Executive Officer NitroMed, Inc. 12 Oak Park Drive Bedford, MA 01730 Edwards, Barry, Ph.D. Assistant Professor Washington University School of Medicine Division of Radiological Sciences 510 S. Kingshighway Blvd. St. Louis, MO 63110 McElvany, Karen D., Ph.D. 5 505 Parnassus Ave. San Francisco, CA University of North Carolina School of Medicine 701 Meadowmont Lane Chapel Hill, NC 27517 Vavere, Amy, Ph.D. Head Radiochemist Molecular Imaging Research St. Jude’s Children’s Research Hospital 262 Danny Thomas Place, MS #220 Memphis, TN 38105 Moerlein, Stephen, Ph.D. Associate Professor Mallinckrodt Institute of Radiology Washington University School of Medicine 510 S. Kingshighway Blvd. St. Louis, MO 63110 Wallace, Susan L., Ph.D. General Manager Philips Radiation Oncology Services Philips Healthcare 3000 Minuteman Road Andover, MA 01810-1099 Rogers, Buck E., Ph.D. Associate Professor Department of Radiation Oncology Washington University School of Medicine 4511 Forest Park Blvd. St. Louis, MO 63108 Zhang, Jian, Ph.D. Sagent Technology, Inc. 800 W. El Camino Real, 3rd Floor Mountain View, CA 94040 VanBrocklin, Henry F., Ph.D. Professor, Department of Radiology Director of Radiopharmaceutical Research University of California San Francisco Select Post-Doctoral Fellows/Collaborators – present positions Columbia, MO 65211 Anderson, Carolyn J. Ph.D. Professor, Department of Radiology Washington University Medical Center 510 South Kingshighway Blvd. Green, Mark, A. Ph.D. Saint Louis, MO 63110 Department of Radiology and Imaging Sciences Bass, Laura, Ph.D. Indiana University School of Medicine Research Scientist 950 West Walnut Street, R2; E-124 Monsanto Company Indianapolis, IN 46202-5181 700 Chesterfield Parkway Chesterfield, MO 63198 Hagooly, Aviv, Ph.D. Lab Manager, Cyclotron Unit Cutler, Cathy, Ph.D. Hadassah Hebrew University Hospital Research Scientist p.o.b 12000 University of Missouri-Columbia 91120 Jerusalem Research Reactor Center Israel Columbia, MO 65211 Eric Hostetler, Ph.D. Department of Imaging Research Merck Research Laboratories West Point, PA Deal, Kim A., Ph.D. Research Scientist The CNA Corporation 4401 Ford Avenue Alexandria, VA 22302 Dah-Ren Hwang, Ph.D. Senior Scientist Amgen. Inc. 1 Amgen Center Dr Newbury Park, CA 91320-1730 Ehrhardt, Gary, Ph.D. Scientist Reactor Research Center University of Missouri 6 MS 8260/2605 Groton, CT 06340 Jerabek, Paul, Ph.D. Associate Professor PET Center Texas Health Science Center 7703 Floyd Curl Drive San Antonio, TX 78284 McQuade, Paul, Ph.D. Senior Research Chemist Merck & Co., Inc. P.O. Box 4 West Point, PA 19486 Jones-Wilson, Michelle, Ph.D. Assistant Professor Department of Chemistry Ashland University Ashland, OH 44805 Mishani, Eyal, Ph.D. Chief Chemist Department Med Biophysics & Nuclear Med Hadassah University Hospital En Karem P.O. Box 12000 IL-91120 Jerusalem, Israel Kilbourn, Michael R., Ph.D. Professor Department of Radiology University of Michigan Ann Arbor, MI 48109 Moore, Dennis, Ph.D. Research Scientist Covidien AE St. Louis, MO Krohn, Kenneth A. Ph.D. Professor Department of Radiology Imaging Research Laboratory Box 356004 University of Washington Seattle, WA 98195 Tetsuya Mori, Ph.D. Associate Professor, Radiopharmaceutical Chemistry Division University of Fukui, Biomedical Imaging Research Center Fukui, Japan Lannoye, Greg Ph.D. Research Scientist Abbott Laboratories Dept. #54C North Chicago, IL 60064 Patrick, Timothy, Ph.D. Professor Department of Chemistry Southern Illinois University Edwardsville, IL 62026 Lee, Sang-Yoon, Ph.D. Research Professor Neuroscience Research Institute Gachon University of Medicine and Science 1197 Guwol-dong Namdong-gu Incheon Korean Ponde, Datta,Ph.D. Assistant Professor University of Pennsylvania 3700 Market St., Suite 305 Philadelphia, PA 19104 Reichert, David, Ph.D. Assistant Professor Washington University Medical Center 510 South Kingshighway Blvd. St. Louis, MO 63110 Maeda, Minoru, Ph.D. Professor of Radiopharmaceutical Chemistry School of Pharmacy Kyushu University Maidashi 3-1-1 Higashi-Ku Fukuoka, Japan 812-8582 Rossin, Raffaella, Ph.D. Senior Scientist Department of Biomolecular Engineering Philips High Tech Campus I I 5656 AE Eindhoven The Netherlands McCarthy, Timothy J. Ph.D. Associate Director World Wide Clinical Technology Pfizer Global R&D One Eastern Point Rd. 7 Rowland, Doug Scientific Manager Department of BioMedical Engineering University of California, Davis 451 East Health Sciences Drive Davis, CA 95616 Wei, Liuhui Senior Science Specialist MDS Nordion 447 Marce Road Ottowa, Ontario K2K1XS Canada Saji, Hideo, PhD , Professor, Director Radiopharmacy Prog. Graduate School of Pharmaceutical Science Kyoto University Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan Yamamoto, Fumihiko, Ph.D. (Hiko) Associate Professor of Lactosome Project Department of Experimental Therapeutics Translational Research Center Kyoto University Hospital 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JAPAN Sun, Xiankai, Ph.D. Assistant Professor Department of Radiology UT Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard Dallas, TX 75390-9058 Yapp, Donald Research Scientist British Columbia Cancer Center Vancouver, B.C. Canada Tewson, Timothy J., Ph.D. Professor University of Iowa Department of Radiology 200 Hawkins Drive, PET Center, 0917 JPP Iowa City, IA 52242 Yoo, Jeongsoo Associate Professor Department of Molecular Medicine Kyungpook National University 101, Dongin-dong 2-ga Joong-gu, Daegu 700-422 Korea Thakur, Matthew L., Ph.D. Professor Department of Radiology Thomas Jefferson University 1020 Locust Street, Suite 359JAH Philadelphia, PA 19107 Zheng, Lei, Ph.D. Assistant Professor Department of Radiology Case Western Reserve University Cleveland, OH 44106 Wang, Zheng Jim, Ph.D. Director, Molecular Imaging MPI Research 54943 N. Main Street Mattowan, MI 49071 Zhou, Dong Research Instructor Department of Radiology Washington University 510 S. Kingshighway Blvd. Campus Box 8225 St. Louis, MO 63110 Ongoing Research Support: R24 CA086307 (Welch) 09/01/99-8/31/11 NIH/NCI Radionuclide Resource for Cancer Applications This project develops technology for the production of radionuclides and radiopharmaceuticals for applications in oncology. It also provides resources for radionuclides for a number of collaborating institutions around the United States. Role: Principal Investigator 8 P30 CA91842 (Eberlein) 07/01/04-6/30/11 NIH/NCI Cancer Center Support Grant Major goals statement: Established in 1995 (named in 1999), the SCC’s goals are to: (1) be a national leader in the research efforts of basic cancer biology. (2) develop infrastructure to promote and expand translational cancer research. (3) develop the highest quality, multidisciplinary cancer patient care program. (3) develop infrastructure such that all SCC patients will have the opportunity to participate in clinical trials. (5) develop community-based education and outreach programs. (6) encourage active participation of community physicians. Role: Program Leader 1 U01 HL080729-01 (Wooley) 05/01/05 - 04/30/11 NIH/NHLBI Integrated Nanosystems for Diagnosis and Therapy A multidisciplinary team of scientists, nanotechnologists and physicians will establish a Program of Excellence in Nanotechnology (PEN), with the central focus being research and educational activities related to “Integrated Nanosystems for Diagnosis and Therapy”. The central mission is the development of a group of well-characterized and versatile nanoscale agents that can be assembled, labeled, targeted, filled, and activated as needed for the combined purposes of diagnosis and treatment of various diseases of relevance to NHLBI. The overall experimental strategy will focus on biological models of acute pulmonary and systemic vascular injury (in vitro and in vivo) to demonstrate the effectiveness of these agents. There are six specific aims: (1) Preparation and assembly of programmed, integrated nanosystems; (2) Application of nanostructures for imaging at increased levels of sensitivity; (3) Imaging of gene expression by recognition of mRNA transcription products; (4) Application of the nanostructures for therapy; (5) Cross disciplinary education and training of medical and materials scientists, and; (6) Dissemination and translation of nanotechnology developments. Role: Investigator, Head of Imaging Components DE-FG02-08ER64671 (Welch) 09/01/08 - 08/31/11 DOE Novel Strategies for Ultrahigh Specific Activity Targeted Nanoparticles The goal of this grant is to utilize click chemistry to prepare very high specific activity labeled nanoparticles for PET imaging. The particles will be targeted to the estrogen, CA-9 and CA-12 receptors. Role: Principal Investigator DE-SC0002032 10/01/09 – 09/30/12 DOE Integrated Research Training Program of Excellence in Radiochemistry The goal of this training grant is provide a rich and deep research experience in state-of-the-art radiochemistry and in the fundamentals of radioisotopic labeling and tracer methodology to develop researchers who will be capable of meeting the challenges of designing and preparing radiotracers of broad applicability for monitoring and imaging diverse biological systems and environmental processes. Role: Principal Investigator 9 U01CA8009812 (Welch) 01/01/10-12/31/10 American College of Radiology/NIH Phase II Trial of 64Cu-ATSM PET/CT assessment of Tumor Hypoxia in Cervical Cancer This project is part of a multi-center trial to evaluate copper-ATSM as a predictive agent of tumor hypoxia in cervical cancer. Role: Principal Investigator 2 R01 CA025836-28A1 07/01/07 – 06/30/12 NIH / Subcontract from Univ. of Illinois Radiopharmaceuticals for Breast Tumor Imaging and Therapy In this subcontract, agents developed at the University of Illinois are radiolabeled and tested in animal models. U01CA141541-01 (Schreiber) 08/01/09-07/31/10 NIH Translational Insights into Estrogen Receptor alpha-Positive Luminal Breast Cancer Imaging is being utilized to study a new rodent model of luminal breast cancer. The use of imaging biomarkers to monitor therapy is being evaluated. Role: Head of Imaging Component 1R01CA138527-01A1 (Xia) 12/01/09 – 11/30/14 NIH/NCI Gold Nanocages as a New Class of Therapeutic Agents for Photothermal Cancer Treatment This project has the goal of developing targeted gold nanoparticles for tumor therapy. The biodistribution and pharmacokinetics of the nanoparticles will be determined by molecular imaging. Role: Head of Imaging Component V Foundation/Kay Yow Fund 05/01/09-04/30/11 Targeted Nanoparticles Optimized for Breast Cancer Diagnosis and Therapy The overall objective of this project is to improve the diagnosis and treatment of breast cancer through the development of nanoparticle based agents targeting intracellular gene transcripts. Role: Principal Investigator 2006107 United States/Israel Binational Science Foundation (S. Rozen and M. Welch) Fluoro Organic Chemistry with Special Emphasis on Positron Emission Tomography This grant has had continuous funding for 20 years from BSF. It is to fund a collaboration between Professor Rozen at Tel Aviv University and Washington University. The goals of the grant are to develop novel organofluorine chemistry that can be applied to the production of radiopharmaceuticals. Professor Rozen’s work led to the first high-yield rapid synthesis of the important PET radiopharmaceutical 2-fluoro-2-deoxyglucose (FDG). Role: Co-Principal Investigator DESC0004038 10/01/09 – 09/30/11 DOE Improved Production and Separation Technologies for Non-Standard PET Radionuclides This project involves new techniques to increase the production yield and separation techniques for the radionuclides Cu-64, Y-86, Br-76 and Zr-89. Novel techniques will be utilized including the application of microfluidics to the separation of these radionuclides. Role: Principal Investigator 10 HHSN268201000046 (Welch) 08/20/10 – 08/19/15 NHLBI Integrated Nanosystems for Diagnosis and Therapy This contract is part of the NHLBI PEN program. The aims are the same as those in the no-cost extension of our previously funded grant (see U01 HL080729 (above)). Role: Principal Investigator DE-FOA-0000265 (Katzenellenbogen) 09/01/10 – 08/31/13 DOE/ Subcontract from University of Illinois Expedited Synthesis of Fluorine-18 Labeled Phenols: A Missing Link in PET Radiochemistry The goal of this proposal is to develop novel radiosynthetic techniques for the production of high specific activity F-18 labeled phenols. The organic chemists in the Katzenellenbogen group will investigate the non-radioactive synthesis and the radiosynthetic techniques as well as evaluation in animals will be carried out at Washington University under the subcontract. Role: Principal Investigator, Subcontract Completed Major Research Support: 5 RO1HL60088 (Welch) 4/1/98 – 3/31/04 NIH PET Radiopharmaceuticals for Cardiac and Other Studies The major goal of this project was to develop new PET radiopharmaceuticals targeted to the enzyme nitric oxide synthase. Role: Principal Investigator DE-FG02-87ER-60512 (Welch) 01/01/87-06/30/06 DOE Preparation of Radiopharmaceuticals Labeled with Metal Radionuclides The major goal of this project is to support novel approaches to the preparation of new metal based radiopharmaceuticals for tumor imaging. Role: Principal Investigator DE-FG02-84ER-60218 (Welch) 04/01/84-06/30/06 DOE Labeling of Receptor Ligands & Other Compounds with Halogen Radionuclides The major goals of this project are to develop receptor ligands labeled with fluorine-18 and other halogens for tumor imaging. This supports a collaboration with Dr. John Katzenellenbogen of the University of Illinois. This grant ended on 6/30/06 due to lack of funding in DOE. Role: Principal Investigator R24-CA83060 (Ackerman/Welch, Co-PI’s) 09/01/99-8/31/10 NIH/NCI PET Component Washington University Small Animal Imaging Resource (WUSAIR) WUSAIR is one of the five originally funded NCI Small Animal Imaging Resource Program (SAIRP) centers. The goal of this project is to provide small animal MRI and PET resources to the University and St. Louis cancer research community. Primary WUSAIR imaging systems include two 4.7 tesla MRI systems and a Concorde microPET. The programs’ focus is on development of new imaging techniques and methods and applications to cancer biology. Role: Investigator 11 P01 HL13851 (Gropler) 06/01/76-11/30/09 NIH/HLBI P.I., Project 2, Core B Cyclotron Produced Isotopes in Biology and Medicine The major goals of this program project are to carry out cardiovascular research particularly related to diabetes. This grant, which has a resubmission for a competitive renewal under evaluation has been funded for 44 years, Dr. Welch was Principal Investigator on this grant for 24 years prior to the change in Principal Investigator. Role: Investigator Patents: Cance, William G., Davie, Joseph M., Wells, Samuel A., Dilley, William G. and Welch, Michael J.: Monoclonal antibodies and cell lines for parathyroid tissue-specific antigen parathyroidspecific. #4,864,020, September 5, 1989. Cance, William G., Davie, Joseph M., Wells, Samuel A., Dilley, William G. and Welch, Michael, J.: Monoclonal antibodies and cell lines for parathyroid tissue-specific antigen. #5,053,491, October 1, 1991. Shefer, Ruth E., Klinkowstein, Robert E., Hughey, Barbara J., Welch, Michael J., and Dence, Carmen S.: Method for producing radioisotopes. #5,468,355, November 21, 1995. Welch, Michael J., McCarthy, Deborah W., Shefer, Ruth E. and Klinkowstein, Robert, E.: Production of 64Cu and other radionuclides using a charged-particle accelerator. #694,905, August 9, 1996. Mach, Robert H., Tu, Will, Rowland, Douglas, J. Jr. and Welch, Michael J.: Sigma-2 Receptor Radiotracers for imaging the proliferation of solid tumors. Filing date - July 31, 2004. Welch, Michael J., Tang, Lucie Li Wa, Gaehle, Gregory Glen and Lewis, Jason Stuart: Automated separation, purification and labeling system for 60Cu, 61Cu and 64Cu radionuclides and recovery thereof. Filing date - August 7, 2004. Welch, Michael John, Tang, Lucie Li Wa, and Rowland, Douglas, J. Jr.: Enhanced separation process for 76Br, 77Br and 124I) preparation and recovery. Filing date – August 7, 2004. Publications: 1. Pritchard, J., Urch, D.S. and Welch, M.J. The purification of helium-3. J Inorg Nucl Chem 26:1121, 1964. 2. Baker, R., Urch, D.S. and Welch, M.J. Another simple rotary evaporator. Chem and Ind:55, 1964. 3. Welch, M.J. Reactions of recoil hydrogen atoms with simple hydrocarbons. University of London (Ph.D. Thesis), July 1965. 4. Urch, D.S. and Welch, M.J. Wall effects in gas-phase recoil tritium chemistry. Chem Comm:126, 1965. 5. Urch, D.S. and Welch, M.J. Reactions of hot tritium atoms with the system, ethane and oxygen. Trans Faraday Soc 61:1411-1416, 1965. 12 6. Johnston, A.J., Malcolme-Lawes D.J., Urch, D.S. and Welch, M.J. The formation of excited ethane in the tritium recoil labeling reaction. Chem Comm:187, 1966. 7. Urch, D.S.and Welch, M.J. The reactions of recoil tritium atoms with ethane in the presence of various inert moderators. Radiochimica Acta 5:202, 1966. 8. Malcolme-Lawes, D.J., Urch, D.S. and Welch, M.J. A further study of wall effects in gas-phase recoil tritium chemistry. Radiochimica Acta 6:184, 1966. 9. Urch, D.S., Welch, M.J. and Johnston, A.J. The recoil tritium labeling reaction as a function of tritium energy and molecular size. J Lab Cmpds III:403-410, 1967. 10. Welch, M., Withnell R. and Wolf, A.P. A new window flow proportional counter for counting radioactive G.L.C. effluents. Anal Chem 39:275, 1967. 11. Urch, D.S. and Welch, M.J. The chemistry of recoil tritium atoms, Part I: Reaction with n-butane, n-pentane and neopentane. Trans Faraday Soc 64:1547, 1968. 12. Welch, M.J.and Wolf, A.P. Reaction intermediates in the chemistry of recoil carbon atoms. Chem Comm, p 117, 1968. 13. Martinotti, F.F., Welch, M.J. and Wolf, A.P. The reactivity of thermal carbon atoms in the gas phase. Chem Comm 115: 1968. 14. Welch, M.J. and Ter-Pogossian, M.M. Preparation of short half-lived gases for medical studies. Radiation Research 36:580, 1968. 15. Potchen, E.J. and Welch, M. 13N2O coincidence counting for rCBF measurement. Theoretical considerations. Scan J Lab & Clin Med Suppl, p 102, 1968. 16. Potchen, E.J., Adatepe, M., Welch, M., Archer, E. and Studer, R. 113mIndium A. Broad spectrum scanning agent for visualizing the body organs. JAMA:205, 1968. 17. Adatepe, M., Welch, M., Archer, E., Studer, R. and Potchen, E.J. The laboratory preparation of indium labeled colloids. J Nucl Med 9:426, 1968. 18. Potchen E.J. and Welch, M.J. Radiologic assessment of extravascular albumin - An index of lymph transport. Lymphology 1:58, 1968. 19. Welch, M.J. Production of active molecular nitrogen by the reaction of recoil nitrogen-13. Chem Comm:1354, 1968. 20. Welch, M.J., Adatepe, M.and Potchen, E.J. An analysis of technetium (99mTcO4) kinetics: The effect of perchlorate and iodide pretreatment. Int J Appl Radiatl Isot 20:437, 1969. 21. Penkoske, P., Potchen, E.J., Welch, M.J.and Welch, T.J. The clinical chemistry of the tin-indium generator. J Nucl Med 10:646, 1969. 22. Welch, M.J., Lifton, J.F. and Ter-Pogossian, M.M. The preparation of millicurie quantities of oxygen-15 labeled water. J Lab Cmpds 5:168, 1969. 23. Welch, M.J., Adatepe, M. and Potchen, E.J. An analysis of technetium (99mTC04)kinetics: The effect of perchlorate and iodide pretreatment. Int J Appl Radiat Isot 13 20:437, 1969. 24. Ter-Pogossian, M.M., Eichling, J.O., Davis, D.O., Welch, M.J. and Metzger, J.M. The determination of regional cerebral blood flow by means of water labeled with radioactive oxygen-15. Radiology 93:31, 1969. 25. Welch M.J. and Wolf, A.P. The formation of excited intermediates in recoil carbon atom reactions. Pressure Dependence Studies in Gas Phase. J Am Chem Soc 91:6584, 1969. 26. Welch, M.J., Withnell R. and Wolf, A.P. An automatic GLPC apparatus for the analysis of organic compounds labeled with short-lived radioisotopes. Chem Instrumentation 1:177, 1969. 27. Welch, M.J., Lifton, J.F. and Seck, J.A. Tracer studies with radioactive oxygen-15. Exchange between carbon dioxide and water. J Phys Chem 73:3351, 1969. 28. Hill, T., Welch, M., Adatepe, M. and Potchen, E.J. A simplified method for the preparation of indium DTPA brain scanning agent. J Nucl Med 11:28, 1970. 29. Ter-Pogossian, M.M., Eichling, J.O., Davis, D.O. and Welch, M.J. The measure in vivo of regional oxygen utilization by means of oxyhemoglobin labeled with radioactive oxygen-15. J Clin Invest 49:381, 1970. 30. Welch, M.J. Labeling with iodine-123; the reactivity of iodine-123 formed by decay of xenon-123. J Am Chem Soc 92:408, 1970. 31. Urch, D.S., Welch, M.J. and Arthy, R.J. Chemistry of recoil tritium atoms, Part II: The relative energies of hot atom reactions. Trans Faraday Soc 66:1642, 1970. 32. Lifton, J.F. and Welch, M.J. The preparation of glucose labeled with 20 minutes half-lived carbon-11. Radiat Res 45:35-40, 1971. 33. Welch, M.J. and Lifton, J.F. The fate of nitrogen-13 formed by the 12C(d,n)13 N reaction in inorganic carbides. J Am Chem Soc 93:3385, 1971. 34. Adatepe, M., Welch, M.J., Evens, R.G. and Potchen E.J. Clinical application of the broad spectrum scanning agent, indium-113m. Am J Roentgen, Rad Ther and Nucl Med 112:701, 1971. 35. Adatepe, M.J., Studer, R., Welch, M. and Potchen E.J. A comparison of "OH" and "PO4" buffer on the organic distribution of indium colloids in the rat. Int J Appl Radiat Isot 22:220, 1971. 36. Krohn K., Sherman, L. and Welch, M.J. Studies of radioiodinated fibrinogen I. Physicochemical properties of the ICA, chloramine-T and electrolytic reaction products. Biochim Biophys Acta 285:404, 1972. 37. Carter, C.C., Lifton, J.F. and Welch, M.J. Organ uptake, blood pH effect and blood ammonia concentration effects of ammonia measured in dogs determined using ammonia labeled with ten-minute half-lived nitrogen-13. Neurology 23:204, 1973. 14 38. Loberg, M.D. and Welch, M.J. The reactions of recoil iodine formed by the 123Xe - 123I system with simple hydrocarbons: The effect of additives on the reactivity. J Am Chem Soc 93:1075, 1973. 39. Metzger, J., Secker-Walker, R., Krohn, K., Welch, M. and Potchen, E.J. Unsatisfactory biological behavior of I-fibrinogen labeled by the chloramine-T method. J Lab Clin Med 82:267, 1973. 40. Straatmann, M.G. and Welch, M.J. The liquid chromatographic purification of carbon-11 labeled glucose. J Appl Radiat Isot 24:234, 1973. 41. Loberg, M., Krohn, K. and Welch, M. Reactions of recoil iodine formed by the 123Xe _ 123 I system with simple hydrocarbons II. Pressure studies on the methane and ethane systems. J Am Chem Soc 95:5496, 1973. 42. Loberg, M.D., Phelps, M.E. and Welch, M.J. Preparation of pure carrier-free xenon-123 for rare gas washout studies. J Nucl Med 14:733, 1973. 43. Welch, M.J.and Straatmann, M.G. The reactions of recoil 13N atoms with some organic compounds in the solid and liquid phases. Radiochimica Acta 20:124, 1973. 44. Straatmann, M.G. and Welch, M.J. Enzymatic synthesis of nitrogen-13 labeled amino acids. Radiat Res 56: 48, 1973. 45. Raichle, M., Phelps, M., Larson, K., Grubb, R., Welch, M. and Ter-Pogossian, M. In vivo measurement of cerebral glucose metabolism employing 11C-labeled glucose. Trans Am Neurol Assoc 98, 1973. 46. Urch, D.C. and Welch, M.J. The relative reactivities of ethane, ethaned, n-butane and neopentane toward "hot" tritium atoms. Radiochim Acta 21:81-87, 1974. 47. Henis, J.M.S., Loberg, M.D. and Welch, M.J. Ion molecule reactions in methyl halides. J Am Chem Soc 96: 1665, 1974. 48. Straatmann, M.G., Hortmann, A.G. and Welch, M.J. Production of l-11C-acetoacetic acid. J Lab Cmpds 10:175, 1974. 49. Krohn, K.A. and Welch, M.J. Studies of radioiodinated fibrinogen II. Lactoperoxidase iodination of fibrinogen and model compounds. Int J Appl Radiat Isot 25:315, 1974. 50. Coleman, R. E, Krohn, K.A., Metzger, J.M., Welch, M.J., Secker-Walker, R.H. and Siegel, B.A. An in vivo evaluation of *I-fibrinogen labeled by four different methods. J Lab Clin Med 83:977, 1974. 51. Raichle, M.E., Larson, K.B., Phelps, M.E., Grubb, R.L., Welch, M.J. and Ter-Pogossian, M.M. In vivo measurement of brain glucose transport and metabolism employing 11 C-glucose. Amer J Physiol 288: 1936, 1975. 52. Larson, K.B., Raichle, M.E., Phelps, S.E., Grubb, R.L., Welch, M.J. and Ter-Pogossian, M.M. A mathematical model for in vivo measurement of metabolic rates using externally monitored radiotracers. Computers and Biomedical Research. 53. Straatmann, M.G. and Welch, M.J. A general method for labeling proteins with carbon-11. J Nucl Med 16:425, 1975. 15 54. Coleman, R.E., Harwig, S.L., Harwig, J.F., Siegel, B.A. and Welch, M.J. Fibrinogen uptake by thrombi: Effect of thrombus age. J Nucl Med 16:370, 1975. 55. Harwig, J.F., Coleman, R.E., Harwig, S.S.L., Sherman, L.A., Siegel, B.A. and Welch, M.J. Highly iodinated fibrinogen, a new thrombus localizing agent. J Nucl Med 16:756, 1975. 56. Coleman, R.E., Harwig, S.S.L., Sherman, L.A. and Welch, M.J. Radioiodinated soluble fibrin: preparation and evaluation as a thrombus localizing agent. Circ Res 37:35, 1975. 57. Jiang, V.W., Krohn, K.A. and Welch, M.J. Intramolecular effects of radioiodine decay in ortho-iodophenol. A model for radioiodinated proteins. J Am Chem Soc 97:6551, 1975. 58. Raichle, M.E., Eichling, J.O., Straatmann, M.G., Welch, M.J. and Ter-Pogossian, M.M. Blood brain barrier permeability of 11C-labeled alcohols and 15O-labeled water. Amer J Physiol 230:543-552, 1976. 59. Harwig, J.F., Harwig, S.S.L., Wells, L.D. and Welch, M.J. Preparation and in vitro properties of 99mTc-fibrinogen. Int J Appl Radiat Isot 27:5, 1976. 60. Harwig, S.S.L., Harwig, J.F., Coleman, R.E. and Welch, M.J. The in vivo behavior of 99m Tc-fibrinogen and its potential as a thrombus imaging agent. J Nucl Med 17:40, 1976. 61. Phelps, M.E., Hoffman, E., Coleman, R.W., Welch, M.J., Raichle, M.E., Weiss, E., Sobel, B.E. and Ter-Pogossian, M.M. Tomographic images of blood pool and perfusion in brain and heart. J Nucl Med 17:603-612, 1976. 62. Thakur, M.L., Coleman, R.W., Mayhall, C.G. and Welch, M.J. Indium-111 labeled leukocytes: preparation and evaluation as an abscess imaging agent. Radiology 119, 731-732, 1976. 63. Weiss, E.S., Hoffman, E.J., Phelps, M.E., Welch, M.J., Henry P.D., Ter-Pogossian, M.M. and Sobel B.E. External detection and visualization of myocardial ischemia with 11 C-substrates in vitro and in vivo. Cir Res 39:24-32, 1976. 64. Harwig, J.F., Welch, M.J. and Coleman, R.E. I-labeled highly iodinated fibrinogen: Preparation and use for imaging deep vein thrombi. J Nucl Med 17:397-400, 1976. 65. Harwig, S.S.L., Lee, J.L.C., Sherman, L.A., Harwig, J.F. and Welch, M.J. Solid phase bovine thrombin: Preparation and properties. Biochim Biophys Acta 438:231-238, 1976. 66. Thakur M.L., Welch, M.J., Joist, J.H. and Coleman, R.E. Indium-111 labeled platelets: Studies on preparation and evaluation of in vitro and in vivo functions. Thrombosis Res 9:345-357, 1976. 67. Thakur, M.L., Coleman, R.E. and Welch, M.J. Indium-111 labeled leukocytes for the localization of abscesses: Preparation, analysis, tissue distribution and comparison with gallium-67 citrate in dogs. J Lab Clin Med 89:217-228, 1977 68. Weiss, E.S., Syed, A.A., Welch, M.J., Williamson, J.R., Ter-Pogossian, M.M. and Sobel, B.E. Quantification of infarction in cross sections of canine myocardium in vivo with positron emission transaxial tomography and 11C-palmitate. Circulation 55:66-73, 1977. 16 69. Harwig, S.S.L., Harwig, J.F., Sherman, L.A., Coleman, R.E. and Welch, M.J. Radioiodinated plasminogen: An imaging agent for pre-existing thrombi. J Nucl Med 18:42-45, 1977. 70. Welch, M.J., Coleman, R.E., Straatmann, M.R., Asberry, B.E., Primeau, J.L., Fair, W.R. and Ter-Pogossian, M.M. Carbon-11 labeled methylated polyamine analogs: Uptake in prostate and tumor in animal models. J Nucl Med 18:74-78, 1977. 71. Knight, L.C., Harwig, S.S.L. and Welch, M.J. In vitro stability and in vivo clearance of fibrinogen or serum albumin labeled with Br-77, I-131 or I-125 by direct or indirect synthetic methods. J Nucl Med 18:282-288, 1977. 72. Straatmann, M.G. and Welch, M.J. 18F-diethylaminosulfur trifluoride (DAST): An F-for-OH fluorinating agent. J Nucl Med 18:151-158, 1977. 73. Krohn, K.A., Knight, L.C., Harwig, J.F. and Welch, M.J. Differences in the sites of iodination of proteins following four methods of radioiodination. Biochim Biophys Acta 490:497-505, 1977. 74. Jiang, V.W. and Welch, M.J. Intramolecular effects of radioiodine decay in 3-iodotyrosine. Radiat Res 69:16-26, 1977. 75. Harwig, J.F., Harwig, S.S.L., Eichling, J.O., Coleman, R.W. and Welch, M.J. 123I-labeled soluble fibrin: Preparation and comparison with other thrombus imaging agents. Int J Appl Radiat Isot 28:157-162, 1977. 76. Harwig, J.F., Alderson, P.O., Primeau, J.L., Boonvisut, S. and Welch, M.J. Development and evaluation of a rapid and efficient electrolytic preparation of 99mTc-labeled red blood cells. Int J Appl Radiat Isot 28:113-121, 1977. 77. Hoffman, E.J., Phelps, M.E., Weiss, E.S., Welch, M.J., Coleman, R.W., Sobel, B.E. and Ter-Pogossian, M.M. Transaxial tomographic imaging of canine myocardium with 11 C-palmitic acid. J Nucl Med 18:57, 1977. 78. Weiss, E.S., Ahmed, S.A., Thakur, M.L., Welch, M.J., Coleman, R.W. and Sobel, B.E. Imaging of the inflammatory response in ischemic canine myocardium with 111 Indium-labeled leukocytes. Am J Cardiol 40:195-199, 1977. 79. Sobel, B.E., Weiss, E.S., Welch, M.J., Siegel, B.A. and Ter-Pogossian, M.M. Detection of remote myocardial infarction in patients with positron emission transaxial tomography and intravenous 11C-palmitate. Circulation 55:853-857, 1977. 80. McIlmoyle, G., Davis, H.H., Welch, M.J., Primeau, J.L., Sherman, L.A. and Siegel, B.A. Scintigraphic diagnosis of experimental pulmonary embolism with In-111 labeled platelets. J Nucl Med 18:910, 1977. 81. Welch, M.J., Thakur, M.L., Coleman, R.W., Patel, M., Siegel, B.A. and Ter-Pogossian, M.M. Gallium-68 labeled red cells and platelets new agents for positron tomography. J Nucl Med 18:558-562, 1977. 82. Thakur, M.L., Segal, A.W., Louis, L., Welch, M.J., Hopkins, J. and Peters, T.J. Indium-111 labeled cellular blood components: Mechanism of labeling and intracellular location in human neutrophils. J Nucl Med 18:1022-1026, 1977. 17 83. Weiss, E.S., Siegel, B.A., Sobel, B.E., Welch, M.J. and Ter-Pogossian, M.M. Evaluation of myocardial metabolism and perfusion with positron-emitting radionuclides. Prog Cardiovasc Dis 20:191-206, 1977. 84. Knight, L.C. and Welch, M.J. Sites of direct and indirect halogenation of albumin. Biochim Biophys Acta 534:185-195, 1978. 85. Tewson, T.J. and Welch, M.J. New approaches to the synthesis of 3-deoxy3-fluoro-D-glucose. J Org Chem 43:1090-1092, 1978. 86. Davis, H.H., Siegel, B.A., Joist, J.H., Heaton, W.A., Mathias, C.J., Sherman, L.A. and Welch, M.J. Scintigraphic detection of atherosclerotic lesions and venous thrombi in man by indium labeled autologous platelets. Lancet:1185-1197, 1978. 87. Raichle, M.E., Welch, M.J., Grubb, R.L. Jr., Higgins, C.S., Ter-Pogossian, M.M. and Larson, K.B. Measurement of regional substrate; utilization rates by emission tomography. Science 199:986-987, 1978. 88. Knight, L.C., Primeau, J.L., Siegel, B.A. and Welch, M.J. Comparison of In-111-labeled platelets and iodinated fibrinogen for the detection of deep vein thrombosis. J Nucl Med 19:891-894, 1978. 89. Tewson, T.J., Welch, M.J. and Raichle, M.E. [18F]-labeled 3-deoxy-3-fluoro-D-glucose: synthesis and preliminary biodistribution data. J Nucl Med 19:1339-1345, 1978. 90. Ehrhardt, G.J. and Welch, M.J. A new germanium-68/gallium-68 generator. J Nucl Med 19:925-929, 1978. 91. Joist, J.H., Baker, R.K., Thakur, M.L. and Welch, M.J. Indium-111 labeled human platelets: uptake and loss of label and in vitro function of labeled platelets. J Lab & Clin Med 92:829-836, 1978. 92. Miller, T.R., Siegel B.A., Fair, W.R., Smith, E.K. and Welch, M.J. Imaging of canine tumors with 11C-methylputrescine. Radiology 129:221-223, 1978. 93. Fair, W.R., Miller, T.R., Siegel, B.A. and Welch, M.J. Radionuclide imaging of dog prostate. Urology 12:575-577, 1978. 94. Klein, M.S., Goldstein, R.A., Welch, M.J. and Sobel, B.E. External assessment of myocardial metabolism with [11C]palmitate in rabbit hearts. Am J Physiol 237(1):H51-H57, 1979. 95. Wagner, S.J. and Welch, M.J. Gallium-68 labeling of albumin and albumin microspheres. J Nucl Med 20:428-433, 1979. 96. Heaton, W.A., Davis, H.H., Welch, M.J., Mathias, C.J., Joist, J.H., Sherman, L.A. and Siegel, B.A. Indium-111: a new radionuclide label for studying human platelet kinetics. British J Hematology 42:613-622, 1979. 97. Tewson, T.J. and Welch, M.J. Preparation of fluorine-18 aryl fluorides: Piperidyl triazenes as a source of diazonium salts. J Chem Soc Chem Commun 1979:1149-1150, 1979. 18 98. Bergmann, S.R., Hack S.N., Tewson, T.J., Welch, M.J. and Sobel, B.E. The dependence of accumulation of 13NH3 by myocardium on metabolic factors and its implications for quantitative assessment of perfusion. Circulation 61:34-43, 1980. 99. Tewson, T.J., Raichle, M.E. and Welch, M.J. Preliminary studies with [18F]haloperidol: a radioligand for in vivo studies of the dopamine receptors. Brain Res 192:291-295, 1980. 100. Davis, H.H. III, Siegel, B.A., Sherman, L.A., Heaton, W.A. and Welch, M.J. Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism. Radiology 136:203-207, 1980. 101. Berridge, M.S., Jiang, V.W. and Welch, M.J. Intramolecular effects of 125I decay in o iodotyrosine. Radiat Res 82:467 477, 1980. 102. Davis, H.H. III, Siegel, B.A., Sherman, L.A., Heaton, W.A., Naidich, T.P., Joist, J.H. and Welch, M.J. Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets. Circulation 61:982-988, 1980. 103. Davis, H.H., III, Siegel, B.A. and Welch, M.J. Scintigraphic detection of an arterial thrombus with In- 111-labeled autologous platelets. J Nucl Med 21:548-549, 1980. 104. Goldstein, R.A., Klein, M.S., Welch, M.J. and Sobel, B.E. External assessment of myocardial metabolism with C-11 palmitate in vivo. J Nucl Med 21:342-348, 1980. 105. Tewson, T.J. and Welch, M.J. Preparation and preliminary biodistribution of "no carrier added" fluorine-18 fluoroethanol. J Nucl Med 21:559-564, 1980. 106. Hack, S.N., Eichling, J.O., Bergmann, S.R., Welch, M.J. and Sobel, B.E. External quantification of myocardial perfusion by exponential infusion of positron-emitting radionuclides. J Clin Invest 66:918, 1980. 107. McElvany, K.D., Barnes, J.W. and Welch, M.J. Characterization of bromine-77 labeled proteins prepared using myeloperoxidase. Int J Appl Radiat Isot 31:679-688, 1980. 108. McElvany, K.D. and Welch, M.J. Characterization of bromine-77 labeled proteins using bromoperosidase. J Nucl Med 21:953-960, 1980. 109. Katzenellenbogen, J.A., Senderoff, S.G., McElvany, K.D., O'Brien, H.A., Jr. and Welch, M.J. 16α[77Br]-Bromoestradiol-17ß. A high specific activity gamma emitting tracer with uptake in rat uterus and induced mammary tumors. J Nucl Med 22:42-47, 1981. 110. Kumar, B., Miller, T.R., Siegel, B.A., Mathias, C.J., Markham, J., Ehrhardt, G.J. and Welch, M.J. Positron tomography imaging of the liver: 68Ga iron hydroxide colloid. Am J Radiology 136:685-690, 1981. 111. McElvany, K.D., Welch, M.J., Katzenellenbogen, J.A., Senderoff, S.G., Bentley, G.E. and Grant, P.M. Scope and limitations of a rapid radiobromination technique. Int J Appl Radiat Isot 32:411-416, 1981. 19 112. Moerlein, S.M., Welch, M.J., Raymond, K.N. and Weitl, F.L. Tricatecholamide analogs of enterobactin as gallium- and indium-binding radiopharmaceuticals. J Nucl Med 22:710-719, 1981. 113. Frost, J.J., Moerlein, S.M. and Welch, M.J. Reactions of recoil bromine formed by the systems 76,77Kr _ 76,77Br with simple hydrocarbons. Solid phase reactions. J Am Chem Soc 103:4333-4337, 1981. 114. Frost, J.J., Moerlein, S.M. and Welch, M.J. Reactions of recoil bromine formed by the 76,77 Kr _ 76,77Br systems with simple hydrocarbons. Pressure and additive effects on gas-phase reactivity. J Am Chem Soc 103:4337-4343, 1981. 115. Lerch, R.A., Ambos, H.D., Bergmann, S.R., Welch, M.J., Ter-Pogossian, M.M. and Sobel, B.E. Localization of viable, ischemic myocardium by positron-emission tomography with 11C-palmitate. Circulation 64:689-699, 1981. 116. Mathias, C.J., Heaton, W.A., Welch, M.J., Douglas, P.G. and Kelly, J.D. Comparison of 111 In-oxine and 111In-acetylacetone for the labeling of cells: in vivo and in vitro biological testing. Int J Appl Radiat Isotop 32:651-656, 1981. 117. Moerlein, S.M. and Welch, M.J. The chemistry of gallium and indium as related to radiopharmaceutical production. Int J Nucl Med Biol 8:277-287, 1981. 118. Pandian, S., Mathias, C.J. and Welch, M.J. Perturbed angular correlation studies of 111 In-labeled platelets. Int J Appl Radiat Isot 33:33-37, 1982. 119. Geltman, E.M., Biello, D., Welch, M.J., Ter-Pogossian, M.M., Roberts, R. and Sobel, B.E. Characterization of nontransmural myocardial infarction by positron-emission tomography. Circulation 65:747-755, 1982. 120. Powers, W.J., Mathias, C.J., Welch, M.J., Sherman, L.A., Siegel, B.A. and Clarkson, T.B. Scintigraphic detection of platelet deposition in atherosclerotic macaques: A new technique for investigation of antithrombotic drugs. Thromb Res 25:137-142, 1982. 121. Lerch, R..A., Bergmann, S.R., Ambos, H.D., Welch, M.J., Ter-Pogossian, M.M. and Sobel, B.E. Effect of flow-independent reduction of metabolism on regional myocardial clearance of 11C-palmitate. Circulation 65:731-738, 1982. 122. Kilbourn, M.R., McElvany, K.D. and Welch, M.J. A simple synthesis of bromine-77-labeled alkyl bromides. Int J Appl Radiat Isot 33:391-392, 1982. 123. Kilbourn, M.R. and Welch, M.J. No-carrier-added synthesis of [1-11C]pyruvic acid. Int J Appl Radiat Isot 33:359-361, 1982. 20 124. McElvany, K.D., Katzenellenbogen, J.A., Shafer, K.E., Siegel, B.A., Senderoff, S.G., Welch, M.J. and Los Alamos Medical Radioisotope Group: 16a-[77Br]bromoestradiol: Dosimetry and preliminary clinical studies. J Nucl Med 23:425-430, 1982. 125. McElvany, K.D., Carlson, K.E., Welch, M.J., Senderoff, S.G., Katzenellenbogen, J.A. and Los Alamos Medical Radioisotope Group: In vivo comparison of 16α[77Br]bromoestradiol-17ß and 16α[125I]iodoestradiol-17ß. J Nucl Med 23:420-424, 1982. 126. Katzenellenbogen, J.A., McElvany, K.D., Senderoff, S.G., Carlson, K.E., Lanvatter, S.W., Welch, M.J. and Los Alamos Medical Radioisotope Group: 16α[77Br]Bromo-11ßmethoxyestradiol-17ß: A gamma-emitting estrogen imaging agent with high uptake and retention by target organs. J Nucl Med 23:411-419, 1982. 127. Moerlein, S.M., Welch, M.J. and Raymond, K.N. Use of tricatecholamide ligands to alter the biodistribution of gallium-67: Concise communication. J Nucl Med 23:501-506, 1982. 128. Powers, W.J., Siegel, B.A., Davis II, H.H., Mathias, C.J., Clark, H.B. and Welch, M.J. Indium-111 platelet scintigraphy in cerebrovascular disease. Neurology 32:938-943, 1982. 129. Kassis, A.I., Adelstein S.J., Haydock, C., Sastry, K.S.R., McElvany, K.D. and Welch, M.J. Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells. Radiat Res 90:362-373, 1982. 130. Bergmann, S.R., Lerch, R.A., Fox, K.A.A., Ludbrook, P.A., Welch, M.J., Ter-Pogossian, M.M. and Sobel, B.E. Temporal dependence of beneficial effects of coronary thrombolysis characterized by positron tomography. Am J Med 73:573-581, 1982. 131. Senderoff, S.G., McElvany, K.D., Carlson, K.E., Heiman, D.F., Katzenellenbogen, J.A. and Welch, M.J. Methodology for the synthesis and specific activity determination of 16α-[77Br]-bromoestradiol-17ß and 16a-[77Br]-11ß-methoxyestradiol-17ß, two estrogen receptor-binding radiopharmaceuticals. Int J Appl Radiat Isot 33:545-551, 1982. 132. Kilbourn, M.R. and Welch, M.J. New methods of radiobromination. The sodium [77Br]bromide/tetrahalomethane/triphenylphosphine reagent system. Int J Appl Radiat Isot 33:1479-1480, 1982. 133. Kilbourn, M.R., Dischino, D.D., Dence, C.S. and Welch, M.J. 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Bergmann, S.R., Lerch, R.A., Mathias, C.J., Sobel, B.E. and Welch, M.J. Noninvasive detection of coronary thrombi with In-111 platelets: Concise communication. J Nucl Med 24:130-135, 1983. 139. Dischino, D.D., Welch, M.J., Kilbourn, M.R. and Raichle, M.E. The relationship between lipophilicity and the brain extraction of radiopharmaceuticals. J Nucl Med 24:1030-1038, 1983. 140. Welch, M.J., Kilbourn, M.R., Mathias, C.J., Mintun, M.A. and Raichle, M.E. Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: potential agents for imaging the dopamine receptor. Life Sciences 33:1687-1693, 1983. 141. Joist, J.H., Baker, R.K. and Welch, M.J. Methodologic and basic aspects of indium-111 platelets. Sem Thromb Hemostasis 9:86-99, 1983. 142. Moerlein, S.M., Welch, M.J. and Wolf, A.P. Reactions with aromatic compounds of recoiling bromine atoms formed from the 76,77Kr, 76,77Kr transformations. Liquid-phase reactions. J Am Chem Soc 105:5418-5428, 1983. 143. Welch, M.J. and McElvany, K.D. Radionuclides of bromine for use in biomedical studies. Radiochimica Acta 34:41-46, 1983. 144. Landvatter, S.W., Kiesewetter, D.O., Kilbourn, M.R., Katzenellenbogen, J.A. and Welch, M.J. (2R*, 3S*)-1-[18F]Fluoro-2,3-bis(4-hydroxyphenyl)pentane ([18F]fluoronorhesestrol), a positron- emitting estrogen that shows highly selective, receptor-mediated uptake by target tissues in vivo. Life Sci 33:1933-1938, 1983. 145. Evens, R.G., Siegel, B.A., Welch, M.J. and Ter-Pogossian, M.M. Cost analyses of positron emission tomography for clinical use. AJR 141:1073-1076, 1983. 146. Welch, M.J., Dence, C.S., Marshall, D.R. and Kilbourn, M.R. Remote system for production of carbon-11-labeled palmitic acid. J Label Cmpds Radiopharm 20:1087-1095, 1983. 147. Kilbourn, M.R., Jerabeck, P.A. and Welch, M.J. Synthesis of carbon-11 labeled amides via cargonylation of lithium dialkylamides. J Chem Soc Chem Commun, p 861-862, 1983. 22 148. Mintun, M.A., Raichle, M.E, Kilbourn, M.R., Wooten, F.G. and Welch, M.J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 15:217-227, 1984 149. Moerlein, S.M., Welch, M.J. and Wolf, A P. The reactions with benzene of recoiling bromine atoms formed from the 76,77Kr - 76,77Br transformations. Effects of phase and non-inert chemical additives. Radiochimica Acta 35:29-35, 1984. 150. Allen, B.T., Long, J.A., Clark, R.E., Sicard, G.A., Hopkins, K.T. and Welch, M.J. Influence of endothelial cell seeding on platelet deposition and patency in small-diameter dacron arterial grafts. J Vascular Surgery 1:224-233, 1984. 151. Allen, B.T., Sparks, R.E., Welch, M.J., Mason, N.S., Mathias, C.J. and Clark, R. E. Reduction of platelet deposition on vascular grafts using an antiplatelet graft coating technique. J Surg Res 36:80-88, 1984. 152. Otsuka, F.L., Welch, M.J., McElvany, K.D., Fleischman, J.B. and Nicolotti, R.A. Development of a model system to evaluate methods for radiolabeling monoclonal antibodies. J Nucl Med 25:1343-1349, 1984. 153. Kiesewetter, D.O., Kilbourn, M.R., Landvatter, S.W., Heiman, D.F., Katzenellenbogen, J.A. and Welch, M.J. Preparation of four fluorine-18-1abeled estrogens and their selective uptakes in target tissues of immature rats. J Nucl Med 25:1212-1221, 1984. 154. Kiesewetter, D.O., Katzenellenbogen, J.A., Kilbourn, M.R. and Welch, M.J. Synthesis of 16-fluoroestrogens by unusually facile fluoride ion displacement reactions: prospects for the preparation of fluorine-18-labeled estrogens. J Org Chem 49:4900-4905, 1984. 155. Green, M.A., Welch, M.J. and Huffman, J.C. Synthesis and crystallographic characterization of a gallium salicylaldimide complex of radiopharmaceutical Interest. J Am Chem Soc 106:3689-3691, 1984. 156. Dence, C.S., Lechner, K.A., Welch, M.J. and Kilbourn, M.R. Remote system for production of carbon-11 labeled glucose via photosynthesis. J Lab Cmpd Radiopharm 21:743-750, 1984. 157. Cunningham, D.A., Kumar, B., Siegel, B.A., Gilula, L.A., Lotty, W.G. and Welch, M.J. Aspirin inhibition of platelet deposition at angioplasty sites: Demonstration by platelet scintigraphy. Radiology 151:487-490, 1984. 158. Powers, W.J., Hopkins, K.T. and Welch, M.J. Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy. Thrombosis Research 34:135-145, 1984. 159. McElvany, K.D., Hopkins, K.T. and Welch, M.J. Comparison of germanium-68/gallium-68 generator systems for radiopharmaceutical production. Int J Appl Radiat Isot 35:521-524, 1984. 23 160. Kilbourn, M.R., Hood, J.T. and Welch, M.J. A simple 0-18 water target for fluorine-18 production. Int J Appl Radiat Isot 35:599-602, 1984. 161. Kilbourn, M.R., Dischino, D.D. and Welch, M.J. Synthesis of DL-[3-11C]phenylalanine. Int J Appl Radiat Isot 35:603-605, 1984. 162. Mathias, C.J. and Welch, M.J. Radiolabeling of platelets. Sem Nucl Med, Vol XIV, No 2:118-127, 1984. 163. Welch, M.J., Raichle, M.E., Kilbourn, M.R. and Mintun, M.A. 18F-Spiroperidol: A radiopharmaceutical for the in-vivo study of the dopamine receptor. Annals of Neurology 15:S77-S78, 1984. 164. Kilbourn, M.R., Welch, M.J., Dence, C.S., Tewson, T.J., Saji, H. and Maeda, M. Carrier-added and no-carrier-added syntheses of [18F]spiroperidol and [18F]haloperidol. Int J Appl Radiat Isot 35:591-598, 1984. 165. Fox, K.A.A., Bergmann, S.R., Mathias, C.J., Powers, W.J., Siegel, B.A., Welch, M.J. and Sobel, B.E. Scintigraphic detection of coronary arterial thrombi in patients with acute myocardial infarction. J Am College Cardiol 4:975-986, 1984. 166. Bergmann, S.R., Fox, K.A.A., Rand, A.L., McElvany, K.D., Welch, M.J., Markham, J. and Sobel, B.E. Quantification of regional myocardial blood flow in vivo with H215O. Circulation 70(4):724-733, 1984. 167. Sicard, G.A., Allen, B.T., Long, J.A., Welch, M.J., Griffin, A., Clark, R.E. and Anderson, C.B. Prostaglandin production and platelet reactivity of small diameter grafts. Journal of Vascular Surgery 1:774-781, 1984. 168. Green, M.A., Welch, M.J., Mathias, C.J., Fox, K.A.A., Knabb, R.M. and Huffman, J.C. Gallium-68 1,1,1-tris(5-methyoxysalicylaldiminiomethyl) ethane: a potential tracer for evaluation of regional myocardial blood flow. J Nucl Med 26:170-180, 1985. 169. Kilbourn, M.R, Jerabek, J.A. and Welch, M.J. An improved [18O]water target for [18F]fluoride production. Int J Appl Radiat Isot 36:327-328, 1985. 170. Welch, M.J., Kilbourn, M.R. and Green, M.A. Radiopharmaceuticals with short-lived positron-emitting radionuclides. Radioisotopes 34:170-179, 1985. 171. Otsuka, F.L. and Welch, M.J. Evidence for a saturable clearance mechanism for 111 In-labeled monoclonal antibodies. Int J Nucl Med Biol 12:331-332, 1985. 172. Green, M.A., Welch, M.J., Mathias, C.J., Taylor, P. and Martell, A.E. Evaluation of PLED as a chelating ligand for the preparation of gallium and indium radiopharmaceuticals. Int J Nucl Med Biol 12:381-386, 1985. 24 173. Jerabek, P.A., Dence, C.S., Kilbourn, M.R., Welch, M.J. and Kadmon, D. Synthesis and uptake of no-carrier-added 1-[11C]putrescine into rat prostate. Int J Nucl Med Biol 12:349-352, 1985. 174. Welch, M.J. and Kilbourn, M.R. A remote system for the routine production of oxygen-15 radiopharmaceuticals. J Labelled Comp Radiopharm 12:1193-1200, 1985. 175. Sicard, G.A., Allen, B.T., Lee, K., Mathias, C.J., Welch, M.J., Long, J.A. and Anderson, C.B. Platelet reactivity as a function of thrombus-free surface in small-diameter vascular grafts. ASAIO 8:86-89, 1985. 176. Unger, E.C., Totty, W.G., Neufeld, D.M., Otsuka, F.L., Murphy, W.A., Welch, M.J., Connett, J.M. and Philpott, G.W. Magnetic resonance imaging using gadolinium labeled monoclonal antibody. Invest Radiol 20:693-700, 1985. 177. Kilbourn, M.R. and Welch, M.J. Fluorine-18 labeled receptor based radiopharmaceuticals. Appl Radiat Isot 37:677-683, 1986. 178. Welch, M.J., Chi, D.Y., Kilbourn, M.R., Brodack, J.W. and Katzenellenbogen, J.A. Biodistribution of N-alkyl and N-fluoroalkyl derivatives of spiroperidol: radiopharmaceuticals for PET studies of dopamine receptors. Int J Nucl Med Biol 13:523-526, 1986. 179. Perlmutter, J., Larson, K.B., Markham, J., Mintun, M.A., Kilbourn, M.R. and Welch, M.J. Strategies for in vivo Measurement of Receptor Binding using Positron Emission Tomography. J Cereb Blood Flow Metab 6:154-169, 1986. 180. Patrick, T.B., Johri, K.H., White, D.H., Bertrand, W.S., Moktar, R., Kilbourn, M.R. and Welch, M.J. Replacement of the Carboxylic Acid Function with Fluorine. Can J Chem 60:138-141, 1986. 181. Chi, D.Y., Kiesewetter, D.O., Katzenellenbogen, J.A., Kilbourn, M.R. and Welch, M.J. Halofluorination of olefins: elucidation of the reaction characteristics and applications in labeling with fluorine-18. J Fluorine Chem 31:99-113, 1986. 182. Hwang, D.R., Jerabek, P.A., Kadmon, D., Kilbourn, M.R., Patrick, T.B. and Welch, M.J. 2-[18F]Fluoroputrescine: Preparation, biodistribution, and mechanism of defluorination. Int J Appl Radiat Isot 37:607-612, 1986. 183. Brodack, J.W., Kilbourn, M.R., Welch, M.J. and Katzenellenbogen, J.A. Application of robotics to radiopharmaceutical preparation: the totally controlled synthesis of fluorine-18 16α-fluoroestradiol-17ß. J Nucl Med 27:714-721, 1986. 184. Jerabek, P.A., Patrick, T.B., Kilbourn, M.R., Dischino, D.D. and Welch, M.J. Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue. Int J Appl Radiat Isot 37:599-605, 1986. 25 185. Brodack, J.W., Kilbourn, M.R., Welch, M.J. and Katzenellenbogen, J.A. NCA 16α-[18F] fluoroestradiol-17ß: The effect of reaction vessel on fluorine-18 resolubilization, product yield, and effective specific activity. Appl Radiat Isot 37:217-221, 1986. 186. Allen, B.T., Mathias, C.J., Sicard, G.A., Welch, M.J. and Clark, R.E. Platelet deposition on vascular grafts. Annals of Surgery 203:318-328, 1986. 187. Chi, D.Y., Kilbourn, M.R., Katzenellenbogen, J.A., Brodack, J.W. and Welch, M.J. Syntheses of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives. Appl Radiat Isot 37:1173-1180, 1986. 188. Otsuka, F.L., Fleishman, J.B. and Welch, M.J. Comparative studies using 125I-and 111 In-labeled monoclonal antibodies. Nucl Med Biol 13:325-334, 1986. 189. Cance, W.G., Wells, Jr., S.A., Dilley, W.G., Welch, M.J., Otsuka, F.L. and Davie, J.M. Human parathyroid antigen: Characterization and localization with monoclonal antibodies. Proceedings of the National Academy of Sciences 83:6112, 1986. 190. Kilbourn, M.R., Dence, C.S., Welch, M.J. and Mathias, C.J. Fluorine-18 labeling of proteins. J Nucl Med 28:462-470, 1987. 191. Chi, D.Y., Kilbourn, M.R., Katzenellenbogen, J.A. and Welch, M.J. A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron-emitting radionuclide F-18. J Org Chem 52:658-664, 1987. 192. Mathias, C.J., Welch, M.J., Kilbourn, M.R., Jerabek, P.A., Patrick, T.B., Raichle, M.E., Krohn, K.A., Rasey, J.S., and Shaw, D.W. Radiolabeled hypoxic cell sensitizers: Tracers for assessment of ischemia. Life Sciences 41:199-206, 1987. 193. Kilbourn, M.R. and Welch, M.J. Positron labeled radiopharmaceuticals for measurement of rCBF. J Nucl Med (Letter to the Editor) 28:134, 1987. 194. Mathias, C.J., Welch, M.J., Katzenellenbogen, J.A., Brodack, J.W., Kilbourn, M.R., Carlson, K.E. and Kieswetter, D.O. Characterization of the uptake of 16α-([18F]fluoro)-17ß-estradiol in DMBA-induced mammary tumors. Nucl Med Biol 14:15-25, 1987. 195. Perlmutter, J.S., Kilbourn, M.R., Raichle, M.E. and Welch, M.J. MPTP-induced up-regulation of in vivo dopaminergic radioligand-receptor binding in man. Neurology 37:1575-1579, 1987. 196. Otsuka, F.L. and Welch, M.J. Methods to label monoclonal antibodies for use in tumor imaging. Nucl Med Biol 14:243-249, 1987. 26 197. Mintun, M.A., Dennis, D.R., Welch, M.J., Mathias, C.J., and Schuster, D.P. Measurements of pulmonary vascular permeability with positron emission tomography and Ga-68 transferring. J Nucl Med 28:1704-1716, 1987. 198. Herscovitch, P., Raichle, M.E., Kilbourn, M.R. and Welch, M.J. Positron emission tomographic measurement of cerebral blood flow and permeability surface area product of water using [15O]water and [11C]butanol. J Cerebral Blood Flow Metabol 7:527-542, 1987. 199. Hwang, D.R., Moerlein, S.M., Lang, L. and Welch, M.J. Application of microwave technology to the synthesis of short-lived radiopharmaceuticals. J Chem Soc, Chem Commun, p 1799-1801, 1987. 200. Welch, M.J., Katzenellenbogen, J.A., Mathias, C.J., Brodack, J.W., Carlson, K.E., Chi, D.Y., Dence, C.S., Kilbourn, M.R., Perlmutter, J.S., Raichle, M.E. and Ter-Pogossian, M.M. N-(3-[F-18]Fluoropropyl)-spiperone: The preferred F-18 labeled spiperone analog for positron emission tomographic studies of the dopamine receptor. Int J Nucl Med Biol 15:83-97, 1988 201. Brodack, J.W., Dence, C.S., Kilbourn, M.R. and Welch, M.J. Robotic production of 2-deoxy-2- [18F]fluoro-D-glucose: A routine method of synthesis using tetrabutylammonium [18F]fluoride. Appl Radiat Isotop 39:699-703, 1988. 202. Brodack, J.W., Kilbourn, M.R. and Welch, M.J. Automated production of several positron-emitting radiopharmaceuticals using a single laboratory robot. Appl Radiat Isot 39:689-698, 1988 (Int J Radiat Appl Instrum, Part A). 203. Cance, W.G., Otsuka, F.L., Dilley, W.G., Scott, R.W., Davie, J.M., Welch, M.J. and Wells, Jr., S.A. A potential new radiopharmaceutical for parathyroid imaging: radiolabeled parathyroid-specific monoclonal antibody - I. Evaluation of 125I-labeled antibody in a nude mouse model system. Nucl Med Biol 15:299-303, 1988 (Int J Radiat Appl Instrum Part B). 204. Otsuka, F.L., Cance, W.G., Dilley, W.G., Scott, R.W., Davie, J.M., Wells, Jr., S.A. and Welch, M.J. A potential new radiopharmaceutical for parathyroid imaging: radiolabeled parathyroid-specific monoclonal antibody - II. Comparison of 125I- and 111In-labeled antibodies. Nucl Med Biol 15:305-311, 1988 (Int J Radiat Appl Instrum Part B). 205. Mathias, C.J., Sun, Y., Welch, M.J., Green, M.A., Thomas, J.A., Wade, K.R. and Martell, A.E. Targeting radiopharmaceuticals: Comparative biodistribution studies of gallium and indium complexes of multidentate ligands. Nucl Med Biol 15:69-81, 1988 (Int J Radiat Appl Instrum Part B). 206. Moerlein, S.M., Hwang, D-R. and Welch, M.J. No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination. Appl Radiat Isot 39:369-372, 1988 (Int J Radiat Appl Instrum, Part A). 207. Pomper, M.G., Katzenellenbogen, J.A., Welch, M.J., Brodack, J.W. and Mathias, C.J. 21-[18F]Fluoro-16α-ethyl-19-norprogesterone: Synthesis and target tissue selective uptake 27 of a progestin receptor based radiotracer for positron emission tomography. J Med Chem 31:1360, 1988. 208. Mintun, M.A., Welch, M.J., Siegel, B.A., Mathias, C.J., Brodack, J.W., McGuire, A.H. and Katzenellenbogen, J.A. Breast cancer: PET imaging of estrogen receptors. Radiology 169:45-48, 1988. 209. Hwang, D-R., Dence, C.S., Bonasera, T.A. and Welch, M.J. No-carrier-added synthesis of 3-[18F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol. A potential PET agent for detecting hypoxic but viable tissues. Appl Radiat Isot 40:117-126, 1989 (Int J Radiat Appl Instrum, Part A). 210. Mathias, C.J., Welch, M.J., Schwartz, D.B., Spaethe, S.M. and Needleman, P. Differentiation in vivo of the sequential blood cell invasion following ureter obstruction of the rabbit kidney. Nucl Med Biol 16:25-32, 1989 (Int J Radiat Appl Instrum, Part B). 211. Shelton, M.E., Dence, C.S., Hwang, D-R. and Welch, M.J. Myocardial kinetics of fluorine-18 misonidazole: A marker of hypoxic myocardium. J Nucl Med 30:351-358, 1989. 212. Moore, D.A., Fanwick, P.E. and Welch, M.J. Synthesis, characterization, and solid-state structure of a new hexachelating ligand and its complex with gallium(III). Inorg Chem 28:1504-1506, 1989. 213. Perlmutter, J.S., Kilbourn, M.R., Welch, M.J. and Raichle, M.E. Non-steady-state measurement of in vivo receptor binding with positron emission tomography: "Dose-response" analysis. J Neurosci 9:2344-2352, 1989. 214. Hwang, D-R., Lang, L., Mathias, C.J., Kadmon, D. and Welch, M.J. N-3-[18F]Fluoropropylputre- scine as potential PET imaging agent for prostate and prostate derived tumors. J Nucl Med 30:1205-1210, 1989. 215. Green, M.A. and Welch, M.J. Gallium radiopharmaceutical chemistry. Nucl Med Biol 16:435-448, 1989 (Int J Radiat Appl Instrum, Part B). 216. Makrigiorgos, G.M., Kassis, A.I., Baranowska-Kortylewicz, J., McElvany, K.D., Welch, M.J., Sastry, K.S.R. and Adelstein, S.J. Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: A comparison with 5-[125I]iodo-2'-deoxyuridine. Radiat Res 118:532-544, 1989. 217. Moerlein, S.M., Brodack, J.W., Siegel, B.A. and Welch, M.J. Elimination of contaminant kryptofix 2.2.2 in the routine production of 2-[18F]fluoro-2-deoxy-D-glucose. Appl Radiat Isot 40:741-743, 1989 (Int J Radiat Appl Instrum Part A). 218. Shelton, M.E., Green, M.A., Mathias, C.J., Welch, M.J. and Bergmann, S.R. Kinetics of copper-PTSM in isolated hearts: A novel tracer for measuring blood flow with positron emission tomography. J Nucl Med 30:1843-1847, 1989. 28 219. Brodack, J.W., Kaiser, S.L. and Welch, M.J. Laboratory robotics for the remote synthesis of generator-based positron-emitting radiopharmaceuticals. LRA 1:285-294, 1989. 220. Chesis, P.L., Griffeth, L.K., Mathias, C.J. and Welch, M.J. Sex-dependent differences in N-(3-[18F] fluoropropyl)-N-nordiprenorphine biodistribution and metabolism. J Nucl Med 31:192-201, 1990. 221. Moerlein, S.M., Lannoye, G.S. and Welch, M.J. No-carrier-added radiosynthesis of [123I]HIPDM: N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-[123I]iodobenzyl)-1,3propanediamine. Appl Radiat Isot 41:253-257, 1990 (Int J Radiat Appl Instrum Part A). 222. Chesis, P.L. and Welch, M.J. Comparison of bromo- and iodoalkyl triflates for 18 F-radiolabeling of amines. Appl Radiat Isot 41:259-265, 1990 (Int J Radiat Appl Instrum Part A). 223. Moore, D.A., Fanwick, P.E. and Welch, M.J. A novel hexachelating amino-thiol ligand and its complex with gallium(III). Inorg Chem 29:672-676, 1990. 224. Mathias, C.J., Welch, M.J., Raichle, M.E., Mintun, M.A., Lich, L.L., McGuire, A.H., Zinn, K.R., John, E.K. and Green, M.A. Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging: Single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM. J Nucl Med 31:351-359, 1990. 225. Moerlein, S.M., Parkinson, D. and Welch, M.J. Radiosynthesis of high effective specific-activity [123I]SCH 23982 for dopamine D-1 receptor-based SPECT imaging. Appl Radiat Isot 41:381-385, 1990 (Int J Radiat Appl Instrum Part A). 226. Pomper, M.G., Pinney, K.G., Carlson, K.E., Van Brocklin, H., Mathias, C.J., Welch, M.J. and Katzenellenbogen, J.A. Target tissue uptake selectivity of three fluorine-substituted progestins: Potential imaging agents for receptor positive breast tumors. Nucl Med Biol 17:309-319, 1990 (Int J Radiat Appl Instrum Part B). 227. Chesis, P.L. and Welch, M.J. Synthesis and in vitro characterization of fluorinated U-50488 analogs for PET studies of kappa opioid receptors. Appl Radiat Isot 41:267-273, 1990 (Int J Radiat Appl Instrum Part A). 228. Mathias, C.J., Sun, Y., Connett, J.M., Philpott, G.W., Welch, M.J. and Martell, A.E. A new bifunctional chelate, BrMe2HBED: An effective conjugate for radiometals and antibodies. Inorg Chem 29:1475-1480, 1990. 229. Motekaitis, R.J., Martell, A.E. and Welch, M.J. Stabilities of trivalent metal complexes of phenolic ligands related to N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED). Inorg Chem 29:1463-1467, 1990. 29 230. Chesis, P.L., Hwang, D-R. and Welch, M.J. N-(3-[18F]Fluoropropyl)-N-nordiprenorphine: Synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography. J Med Chem 33:1482-1490, 1990. 231. Mathias, C.J., Sun, Y., Welch, M.J., Connett, J.M., Philpott, G.W. and Martell, A.E. N,N'-Bis(2-hydroxybenzyl)-1-(4-bromoacetamidobenzyl)-1,2-ethylenediamine-N,N'-diacetic acid: A new bifunctional chelate for radiolabeling antibodies. Bioconjugate Chem 2:204-211, 1990. 232. Shelton, M.E., Dence, C.S., Hwang, D-R., Herrero, P., Welch, M.J. and Bergmann, S.R. In vivo delineation of myocardial hypoxia during coronary occlusion using fluorine-18 fluoromisonidazole and positron emission tomography: A potential approach for identification of jeopardized myocardium. J Am Coll Cardiol 16:477-485, 1990. 233. Lannoye, G.S., Moerlein, S.M., Parkinson, D. and Welch, M.J. N-Fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride. J Med Chem 33:2430-2437, 1990. 234. Pochapsky, S.S., VanBrocklin, H.F., Welch, M.J. and Katzenellenbogen, J.A. Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents. Bioconjugate Chem 2:231-244, 1990. 235. Hwang, D-R., Mathias, C.J., Welch, M.J., McGuire, A.H. and Kadmon, D. Imaging prostate derived tumors with PET and N-(3-[18F]fluoropropyl)putrescine. Nucl Med Biol 17:525-532, 1990 (Int J Radiat Appl Instrum Part B). 236. Shelton, M.E., Green, M.A., Mathias, C.J., Welch, M.J. and Bergmann, S.R. Assessment of regional myocardial and renal blood flow with copper-PTSM and positron emission tomography. Circulation 82:990-997, 1990. 237. Madsen, S.L., Bannochie, C.J., Martell, A.E., Mathias, C.J. and Welch, M.J. Investigation of physicochemical and in vivo behavior of diastereomeric iron-59, gallium-68, and indium-111-EHPG trivalent metal complexes. J Nucl Med 31:1662-1668, 1990. 238. VanBrocklin, H.F., Brodack, J.W., Mathias, C.J., Welch, M.J., Katzenellenbogen, J.A., Keenan, J.F. and Mizejewski, G.J. Binding of 16α-[18F]fluoro-17ß-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels. Nucl Med Biol 17:769773, 1990 (Int J Radiat Appl Instrum Part B). 239. Pomper, M.G., VanBrocklin, H., Thieme, A.M., Thomas, R.D., Kiesewetter, D.O., Carlson, K.E., Mathias, C.J., Welch, M.J. and Katzenellenbogen, J.A. 11ß-Methoxy-, 11ßethyl- and 17α-ethynyl-substituted 16α-fluoroestradiols: Receptor-based imaging agents with enhanced uptake efficiency and selectivity. J Med Chem 33:3143-3155, 1990. 240. Green, M.A., Mathias, C.J., Welch, M.J., McGuire, A.H., Perry, D., Fernandez-Rubio, F., Perlmutter, J.S., Raichle, M.E. and Bergmann, S.R. Copper-62-labeled pyruvaldehyde 30 Bis(N4-methylthiosemicarbazonato)-copper(II): Synthesis and evaluation as a positron emission tomography tracer for cerebral and myocardial perfusion. J Nucl Med 31:19891996, 1990. 241. Welch, M.J. Potential of labeling monoclonal antibodies for positron emission tomography and magnetic resonance imaging. Acta Radiological Suppl 374:129-133, 1990. 242. Martell, A.E., Motekaitis, R.J. and Welch, M.J. N,N',N"-Tris(3-hydroxy-6methyl-2 -pyridyl- methyl)-1,4,7-triazacyclonance, a new effective ligand for iron(III). J Chem Soc Chem Commun 24:1748-1749, 1990. 243. Hwang, D-R., Dence, C.S., McKinnon, Z.A., Mathias, C.J. and Welch, M.J. Positron labeled muscarnic acetylcholine receptor antagonist: 2- and 4-[18F]fluorodexetimide. Syntheses and biodistribution. Nucl Med Biol 18:247-252, 1991. 244. Mathias, C.J., Margenau, W.H., Brodack, J.W., Welch, M.J. and Green, M.A. A remote system for the synthesis of copper-62 labeled Cu(PTSM). Appl Radiat Isot 42:317-320, 1991 (Int J Radiat Appl Instrum Part A). 245. Moerlein, S.M., Daugherty, A., Sobel, B.E. and Welch, M.J. Metabolic imaging with gallium-68- and indium-111-labeled low-density lipoprotein. J Nucl Med 32:300-307, 1991. 246. Sun, Y., Martell, A.E., Reibenspies, J.H. and Welch, M.J. Syntheses of multidentate ligands containing hydroxypryidyl donor groups. Tetrahedron 47:357-364, 1991. 247. Sun, Y., Mathias, C.J., Welch, M.J., Madsen, S.L. and Martell, A.E. Targeting radiopharmaceuticals – II. Evaluation of new trivalent metal complexes with different overall charges. Nucl Med Biol 18:323-330, 1991 (Int J Rad Appl Instrum Part B). 248. Madsen, S.L., Bannochie, C.J., Welch, M.J., Mathias, C.J. and Martell, A.E. TMPHPG: A lipophilic derivative of EHPG for iron, gallium-68, and indium-111 hepatobiliary clearance. Nucl Med Biol 18:289-294, 1991 (Int J Radt Appl Instrum Part B). 249. Mathias, C.J., Welch, M.J., Green, M.A., Diril, H., Meares, C.F., Gropler, R.J. and Bergmann, S.R. In vivo comparison of copper blood-pool agents: Potential radiopharmaceuticals for use with copper-62. J Nucl Med 32:475-480, 1991. 250. Schwarz, S.W., Mathias, C.J., Sun, Y., Dilley, W.G., Wells Jr., S.A., Martell, A.E. and Welch, M.J. Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111. 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Positron tomographic assessment of 16α-[18F]fluoro- 17ß-estradiol uptake in metastatic breast carcinoma. J Nucl Med 32:1526-1531, 1991. 255. Hwang, D-R., Dence, C.S., McKinnon, Z.A., Mathias, C.J. and Welch, M.J. Positron labeled muscarinic acetylcholine receptor antagonist: 2- and 4-[18F]fluorodexetimide. Syntheses and biodistribution. Nucl Med Biol 18:247-252, 1991 (Int J Rad Appl Instrum Part B). 256. Dehdashti, F., McGuire, A.H., VanBrocklin, H.F., Siege, B.A., Andriole, D.P., Griffeth, L.K., Pomper, M.G., Katzenellenbogen, J.A. and Welch, M.J. Assessment of 21-[18F]fluoro16α-ethyl-19-norprogesterone as a positron-emitting radiopharmaceutical for the detection of progestin receptors in human breast carcinomas. J Nucl Med 32:1532-1537, 1991. 257. Hwang, D-R., Eckelman, W.C., Mathias, C.J., Petrillo, Jr., E.W., Lloyd, J. and Welch, M.J. Positron-labeled angiotensin-converting enzyme (ACE) inhibitor: Fluorine-18fluorocaptopril. 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Evaluation of a direct method for technetium labeling intact and F(ab')2 1A3, an anticolorectal onoclonal antibody. Nucl Med Biol 21:619-626, 1994. 35 292. Moerlein, S.M., Perlmutter, J., Welch, M.J. and Raichle, M. First-pass extraction fraction of iodine-123 labeled perfusion tracers in living primate brain. Nucl Med Biol 21:847-855, 1994. 293. O'Neil, J.P., Carlson, K.E., Anderson, C.J., Welch, M.J. and Katzenellenbogen, J.A. Progestin radiopharmaceuticals labeled with technetium and rhenium: synthesis, binding affinity, and in vivo distribution of a new progestin N2S2-metal conjugate. Bioconjugate Chem 5:182-193, 1994. 294. Philpott, G.W., Siegel, B.A., Schwarz, S.W., Connett, J.M., Rocque, P.A., Fleshman, J.W., Wallis, J.W., Baumann, M., Sun, Y., Martell, A.R. and Welch, M.J. Immunoscintigraphy with a new indium-111-labeled monoclonal antibody (MAb 1A3) in patients with colorectal cancer. Dis Colon Rectum 37:782-792, 1994. 295. Buckman, B.O., VanBrocklin, H.F., Dence, C.S., Bergmann, S.R., Welch, M.J. and Katzenellenbogen, J.A. Synthesis and tissue biodistribution of [11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism. J Med Chem, 37:2481-2485, 1994. 296. Duncan, J.R., Franano, N., Edwards, W.B. and Welch, M.J. Evidence of gadolinium dissociation from protein-DTPA-gadolinium complexes. Invest Radiol 29:S58-S61, 1994. 297. Moerlein, S.M., Gropler, R.J., Welch, M.J. and Siegel, B.A. USP Standards for sodium acetate 11C- injection. Pharmacopeial Forum 20:7309-7311, 1994. 298. Shefer, R.E., Hughey, B.J., Klinkowstein, R.E., Welch, M.J. and Dence, C.S. A windowless 13N production target for use with low energy deuteron accelerators. Nucl Med Biol 21:977-986, 1994. 299. Dence, C.S., Welch, M.J., Hughey, B.J., Shefer, R.E. and Klinkowstein, R.E. Production of [13N]ammonia applicable to low energy accelerators. Nucl Med Biol 21:987996, 1994. 300. Edwards, W.B., Fields, C.G., Anderson, C.J., Pajeau, T.S., Welch, M.J. and Fields, G.B. Generally applicable convenient solid-phase and receptor affinities of octreotide analogs. J Med Chem 37:3749-3757, 1994. 301. McCarthy, T.J., Schwarz, S.W. and Welch, M.J. Nuclear medicine and positron emission tomography: an overview. J Chem Educ 71:830-836, 1994. 302. Franano, F.N., Edwards, W.B., Welch, M.J. and Duncan J.R. Metabolism of receptor targeted 111In-DTPA-Glycoproteins: Identification of 111In-DTPA-є-lysine as the primary metabolic and excretory product. Nucl Med Biol 21:1023-1034, 1994. 303. Banks, W.R., Moerlein, S.M., Parkinson, D. and Welch, M.J. Synthesis of ωfluoroalkoxy and alkoxy derivatives of raclopride: evaluation as radioligands for PET study of cerebral dopamine D2 receptors. Med Chem Res 5:150-173, 1994. 36 304. Schuster, D.P., Kaplan, J.D., Gauvain, K., Welch, M.J. and Markham, J. Measurement of regional pulmonary blood flow with PET. J Nucl Med 36:371-377, 1995. 305. Buckman, B.O., Bonasera, T.A., Kirschbaum, K.S., Welch, M.J. and Katzenellenbogen, J.A. Fluorine-18-labeled progestin 16α,17α-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity. J Med Chem 38:328-337, 1995. 306. Moerlein, S.M., Perlmutter, J.S. and Welch, M.J. Stimuli to the revision process. Pharmacopeial Forum 21:172-176, 1995. 307. Anderson, C.J., John, C.S., Li, Y.J., Hancock, R.D., McCarthy, T.J., Martell, A.E. and Welch, M.J. N,N’-Ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies. Nucl Med Biol 22:165-173, 1995. 308. Franano, F.N., Edwards, W.B., Welch, M.J., Brechbiel, M.W., Gansow, O.A. and Duncan, J.R. Biodistribution and metabolism of targeted and nontargeted protein-chelategadolinium complexes: evidence for gadolinium dissociation in vitro and in vivo. Magn Reson Imaging 13:201-214, 1995. 309. Markham, J., McCarthy, T.J., Welch, M.J. and Schuster, D.P. In vivo measurements of pulmonary angiotensin-converting enzyme kinetics. I. Theory and error analysis. J Appl Physiol 78(3):1158-1168, 1995. 310. Schuster, D.P., McCarthy, T.J., Welch, M.J., Holmberg, S., Sandiford, P. and Markham, J. In vivo measurements of pulmonary angiotensin-converting enzyme kinetics. II. Implementation and application. J Appl Physiol 78(3):1169-1178, 1995. 311. Choe, Y.S., Lidstrom, P.J., Chi, D.Y., Bonasera, T.A., Welch, M.J. and Katzenellenbogen, J.A. Synthesis of 11β-[F-18]fluoro-5α-dihydrotestosterone and 11β-[F18]fluoro-19-nor-5α-dihydrotestosterone: preparation via halofluorination-reduction, receptor binding, and tissue distribution. J Med Chem 38:816-825, 1995. 312. Chi, D.Y., Lidstrom, P.J., Choe, Y.S., Bonasera, T.A., Welch, M.J. and Katzenellenbogen, J.A. Bromo[F-18]fluorination of cyclohexenes: a method for the preparation of [F-18]fluorocyclohexanes. J Fluorine Chem 71:143-147, 1995. 313. Anderson, C.J., Schwarz, S.W., Connett, J.M., Cutler, P.D., Guo, L.W., Germain, C.J., Philpott, G.W., Zinn, K.R., Greiner, D.P., Meares, C.F. and Welch, M.J. Preparation, biodistribution and dosimetry of copper-64-labeled anti-colorectal carcinoma monoclonal antibody fragments 1A3-F(ab')2. J Nucl Med 36:850-858, 1995. 314. Katti, K.K., Singh, P.R., Volkert, W.A., Anderson, C.J., Welch, M.J., Hoffman T., Katti, K.V., Ketrig, A.R. and Meifand, W. Synthesis and characterization of a neutral and lipophilic Ph3PN99mTcO3 complex. Appl Radiat Isot 46:53-58, 1995. 37 315. Choe, Y.S., Bonasera, T.A., Chi, D.Y., Welch, M.J. and Katzenellenbogen, J.A. 6α[18F]Fluoro-progesterone: Synthesis via halofluorination-oxidation, receptor binding and tissue distribution. Nucl Med Biol 22:635-642, 1995. 316. Katzenellenbogen, J.A., Coleman, R.E., Hawkins, R.A., Krohn, K.A., Larson, S.M., Mendelsohn, J., Osborne, C.K., Piwnica-Worms, D., Reba, R.C., Siegel, B.A., Welch, M.J. and Shtern, F. Tumor receptor imaging: proceedings of the national cancer institute workshop, review of current work, and prospective for further investigations. Clin Cancer Res 1:921-932, 1995. 317. Moerlein, S.M., Perlmutter, J.S. and Welch, M.J. Specific, reversible binding of [18F]benperidol to baboon D2 receptors: PET evaluation of an improved 18F-labeled ligand. Nucl Med Biol 22:809-815, 1995. 318. Jones-Wilson, T.M., Motekaitis, R.J., Sun, Y., Anderson, C.J., Martell, A.E. and Welch, M.J. New hydroxybenzyl and hydroxypyridylmethyl substituted triazacyclononane ligands for use with gallium(III) and indium(III). Nucl Med Biol 22:859-868, 1995. 319. Dehdashti, F., Mortimer, J.E., Siegel, B.A., Griffeth, L.K., Bonasera, T.J., Fusselman, M.J., Detert, D.D., Cutler, P.D., Katzenellenbogen, J.A. and Welch, M.J. Positron tomographic assessment of estrogen receptors in breast cancer: comparison with FDGPET and in vivo receptor assays. J Nucl Med 36:1766, 1995. 320. Sun, Y., Motekaitis, R.J., Martell, A.E. and Welch, M.J. N,N'-Bis(2mercaptoethyl)ethylene- diamine-N,N'-diacetic acid; an effective ligand for indium(III). Inorg Chim Acta 228:77-79, 1995. 321. Ma, R., Welch, M.J., Reibenspies, J. and Martell, A.E. Stability of metal ion complexes of 1,4,7-tris(2-mercaptoethyl)-1,4,7-triazacyclononane (TACN-TM) and molecular structure of In(C12H24N3S3). Inorg Chem Acta 236:75-82, 1995. 322. Sun, Y., Motekaitis, R.J., Martell, A.E. and Welch, M.J. Stabilities of some trivalent and divalent metal ion complexes of N,N'-bis(2-mercaptoethyl)ethylenediamine-N,N'-diacetic acid, an effective ligand for indium(III). J Coord Chem 36:235-246, 1995. 323. Anderson, C.J., Pajeau, T.S., Edwards, W.B., Sherman, E.L.C., Rogers, B.E. and Welch, M.J. In vitro and in vivo evaluation of copper-64-octreotide conjugates. J Nucl Med 36:2315-2325, 1995. 324. Cutler, P.D., Schwarz, S.W., Anderson, C.J., Connett, J.M., Welch, M.J., Philpott, G.W. and Siegel, B.A. Dosimetry of copper-64-labeled monoclonal antibody 1A3 as determined by PET imaging of the torso. J Nucl Med 36:2363-2371, 1995. 325. Philpott, G., Schwarz, S.S., Anderson, C.J., Dehdashti, F., Connett, J.M., Zinn, K.R., Meares, C.F., Cutler, P.D., Welch, M.J. and Siegel, B.A. RadioimmunoPET: Detection of colorectal carcinoma with positron-emitting copper-64-labeled monoclonal antibody. J Nucl Med 36:1818-1824, 1995. 38 326. Rogers, B.E., Franano, F.N., Duncan J.R., Edwards, W.B., Anderson C.J., Connett, J.M. and Welch, M.J. Identification of metabolites of 111In-diethylenetriaminepentaacetic acid-monoclonal antibodies and antibody fragments in vivo. Cancer Res (Suppl.) 33:5714s5720s, 1995. 327. Li, Y., Martell, A.E., Hancock, R.D., Reibenspies, J.H., Anderson, C.J. and Welch, M.J. N,N'-Ethylenedi-L-cysteine (EC) and its metal complexes: synthesis, characterization, crystal structures and equilibrium constants. Inorg Chem 35:404-414, 1996. 328. Sun, Y., Anderson, C.J., Pajeau, T.S., Reichert, D.E., Hancock, R.D., Motekaitis, R.J., Martell, A.E. and Welch, M.J. Indium(III) and gallium(III) complexes of bis(aminoethanethil) ligands with different densities: stabilities, molecular modeling, and in vivo behavior. J Med Chem 39:458-470, 1996. 329. Mishani, E., Dence, C.S., McCarthy, T.J. and Welch, M.J. Formation of phenylpiperazines by a novel alumina supported bis-alkylation. Tetrahedron Letters, 37:319-322, 1996. 330. Hancock, R.D., Reichert, D.E. and Welch, M.J. Molecular mechanics force field for modeling technetium(V) complexes. Inorg Chem 35:2165-2166, 1996. 331. Mortimer, J.E., Dehdashti, F., Siegel, B.A., Katzenellenbogen, J.A., Fracasso, P. and Welch, M.J. 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Time Course of Alterations in Myocardial Glucose Utilization in the Zucker Diabetic Fatty Rat with Correlation to Gene Expression of Glucose Transporters: A Small-Animal PET Investigation. J Nucl Med 49:1320-1327 2008. 520. Sun, G., Hagooly, A., Xu, J., Nystrom, A.M., Li, Z., Rossin, R., Moore, D.A., Wooley, K.L. and Welch, M.J. Facile, efficient approach to accomplish tunable chemistries and variable biodistributions for shell cross-linked nanoparticles. Biomacromolecules 9(7):19972006, 2008. 521. Mori, T., Sun, L., Kobayashi, M., Kiyono, Y., Okazawa, H., Furukawa, T., Kawashima, H., Welch, M.J. and Fujibayashi, Y. Preparation and Evaluation of Ethyl [18F]Flouroacetate as a Proradiotracer of [18F] Fluoroacetate for the Measurement of Glial Metabolism by PET. Nucl Med Biol 36(2):155-162, 2009. 522. Almutairi, A., Rossin, R., Shokeen, M., Hagooly, A., Ananth, A., Capoccia, B., Guillaudeua, S., Abendschein, D., Anderson, C.J., Welch, M.J. and Frechet, J.M.J. Biodegradable Dendritic Positron-emitting Nanoprobes for the Noninvasive Imaging of Angiogenesis. PNAS 106(3):685-690, 2009. 523. Dehdashti, F., Mortimer, J.E., Trinkaus, K.E., Naughton, M.J., Ellis, M., Katzenellenbogen, J.A., Welch, M.J., Siegel, B.A. PET-based Estradiol Challenge as a Predictive Biomarker of Response to Endocrine Therapy in Women with EstrogenReceptor-Positive Breast Cancer. Breast Cancer Res Treat 113(3):509–517, 2009. 524. Oyama, N., Okazawa, H., Kusukawa, N., Kaneda T., Miwa, Y., Akino, H., Fujibayashi, Y., Yonekura, Y., Welch, M.J., Yokoyama, O. 11C-Acetate PET Imaging for Renal Cell Carcinoma. Eur J Nucl Med Mol Imaging 36(3):422–427, 2009. 525. Zhou, D., Haibing, Z., Jenks, C.C., Lewis, J.S., Katzenellenbogen, J.A. and Welch, M.J. Bromination from the Macroscopic Level to the Tracer Radiochemical Level: 76Br 56 Radiolabeling of Aromatic Compounds via Electrophilic Substitution. Bioconjugate Chem 20: 808–816, 2009. 526. Wei, L., Ye, Y., Wadas, T.J., Lewis, J.S., Welch, M.J., Achilefu, S. and Anderson, C.J. (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nucl Med Biol 36(3):277- 285, 2009. 527. Wei, L., Zhang, X., Gallazzi, F., Miao, Y., Jin, X., Brechbiel, M.W., Xu, H., Clifford, T., Welch, M.J., Lewis, J.S. and Quinn, T.P. Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''- Re(Arg11) CCMSH. Nucl Med Biol 36(4):345-354, 2009. 528. Zhou, D. Lee, H., Rothfuss, J.M., Chen, D.L., Ponde, D.E., Welch, M.J. and Mach, R.H. Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2amine as a potential PET tracer for inducible nitric oxide synthase. J Med Chem 52(8):2443-253, 2009. 529. Zhou, D., Chu, W., Chen, D.L., Wang, Q., Reichert, D.E., Rothfuss, J., D'Avignon, A., Welch, M.J. and Mach, R.H. [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in FAS-treated mice using [11C]WC-98. Org Biomol Chem. 7(7):1337-1348, 2009. 530. Lee, B.C., Dence, C.S. Zhou, H., Parent, E.E., Welch, M.J. and Katzenellenbogen, J.A. Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents. Nucl Med Biol. 36(2):147-153, 2009. 531. Welch, M.J., Hawker, C.J. and Wooley, K.L. The advantages of nanoparticles for PET. J Nucl Med 50:1743-1746, 2009. 532. Shoghi, K.I., Finck, B.N., Schechtman, K.B., Sharp, T., Herrero, P., Gropler, R.J. and Welch, M.J. In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy. Circ Cardiovasc Imaging 2(5):373-81, 2009. 533. Wei, L., Ye, Y., Wadas, T.J., Lewis, J.S., Welch, M.J., Achilefu, S. and Anderson, C.J. (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nucl Med Biol 36(3):277-85, 2009. 534. Liu, Y., Ibricevic-Richardson, A., Cohen, J. A., Cohen, J.L., Gunsten, S.P., Fréchet, J.M.J., Walter, M. J., Welch, M. J. and Brody, S.L. Impact of hydrogel nanoparticle size and functionalization on in vivo behavior for lung imaging and therapeutics. Molecular Pharmaceutics 6(6):1891-1902, 2009. 535. Zhou, D., Zhou, H., Jenks, C.C., Lewis, J.S., Katzenellenbogen, J.A. and Welch, M.J. Bromination from the macroscopic level to the tracer radiochemical level: Br radiolabeling 57 of aromatic compounds via electrophilic substitution. Bioconjugate Chem 20(4):808-816, 2009. 536. Yoshii, Y., Waki, A., Furukawa, T., Kiyono, Y., Mori, T., Yoshii, H., Kudo, T., Okazawa, H., Welch, .MJ. and Fujibayashi, Y. Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET. Nucl Med Biol 36(7):771-777, 2009. 537. Chen, D.L., Zhou, D., Chu, W., Herrbrich, P.E., Jones, L.A., Rothfuss, J.M., Engle, J.T., Geraci, M., Welch, M.J. and Mach, R.H. Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography. Nucl Med Biol 36(6):651-658, 2009. 538. Lapi, S.E., Voller, T.F. and Welch, M.J. Positron emission tomography imaging of hypoxia. PET Clin 4(1):39-47, 2009. 539. Liu, Y., Abendschein, D., Woodard, G.E., Rossin, R., McCommis, K., Zheng, J., Welch, M.J. and Woodard, P.K. Molecular imaging of atherosclerotic plaque with 64Cu-labeled natriuretic peptide and PET. J Nucl Med 51(1):85-91, 2010. 540. Lee, J.H., Zhou, H-B., Dence, C.S., Carlson, K.E., Welch, M.J. and Katzenellenbogen, J.A. Development of [F-18]fluorine-substituted tanaproget as a progesterone receptor imaging agent for positron emission tomography. Bioconjugate Chem 21(6):1096-1104, 2010. 541. Dence, C.S., Laforest, R., Sun, X., Sharp, T.L., Welch, M.J. and Mach, R.H. Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [11C] methylated LY2181308. Mol Imaging Biol 12(6):608-615, 2010. 542. Chen, J., Glaus, C., Laforest, R., Zhang, Q., Yang, M., Gidding, M., Welch, M.J. and Xia, Y. Gold nanocages as photothermal transducers for cancer treatment. SMALL 6(7):811-817, 2010. 543. Tian, M. and Welch, M.J. Translational molecular imaging in drug development: Current status and challenges. Current Medical Imaging Reviews 6(1):51-55, 2010. 544. Yoshii, Y., Furukawa, T., Kiyono, Y., Watanabe, R., Waki, A., Mori, T., Yoshii, H., Oh, M., Asai, T., Okazawa, H., Welch, M.J. and Fujibayashi, Y. Copper-64-diacetyl-bis (N4methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma. Nucl Med Biol 37(4):395-404, 2010. 545. Glaus, C., Rossin, R., Welch, M.J. and Bao, G. In Vivo Evaluation of 64Cu-Labeled Magnetic Nanoparticles as a Dual-Modality PET/MR Imaging Agent. Bioconjugate Chem 21(4):715-722, 2010. 546. Cho, E.C., Glaus, C., Chen, J., Welch, M.J. and Xia, Y. Inorganic nanoparticle-based contrast agents for molecular imaging. Trends Mol Med 16(12):561-573, 2010. 58 547. Park, J.C., Yu, M.K., An, G.I., Park, S.-I., Oh, J., Kim, H.J., Kim, J.-H., Wang, E.K., Hong, I.-H., Ha, Y.S., Choi, T.H., Jeong, K.-S., Chang, Y., Welch, M.J., Jon, S. and Yoo, J. Facile Preparation of a Hybrid Nanoprobe for Triple-Modality Optical/PET/MR Imaging. Small 6:2863-2868, 2010. 548. Yoshii, Y., Furukawa, T., Kiyono, Y., Watanabe, R., Mori, T., Yoshii, H., Asai, T., Okazawa, H., Welch, M.J. and Fujibayashi, Y. Internal radiotherapy with copper-64diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma. Nuc Med Biol 38:151-157, 2011. 549. Oyama, N., Hasegawa, Y., Kiyono, Y., Kobayashi, M., Fujibayashi, Y., Ponde, D.E., Dence, C., Welch, M.J. and Yokoyama, O. Early response assessment in prostate carcinoma by 18F-fluorothymidine following anticancer therapy with docetaxel using preclinical tumour models. Eur J Nuc Med & Mol Imaging 38(1):81-89, 2011. 550. Hagooly, Y., Welch, M.J., Rozen, S. Synthesis of difluoroaryldioxoles using BrF3. Org & Biomolecular Chem 9(3):902-5, 2011. 551. Park, J.C., An, G.I., Park, S.-I., Oh, J., Kim, H.J., Ha, Y.S., Wang, E.K., Kim, K.M., Kim, J.Y., Lee, J., Welch, M.J. and Yoo, J. Luminescence imaging using radionuclides: a potential application in molecular imaging. Nuc Med Biol 38(3):321-329, 2011. 552. Rossin, R., Kohno, T., Hagooly, A., Sharp, T., Gliniak, B., Arroll, T., Chen, Q., Hewig, A., Kaplan-Lefko, P., Friberg, G., Padinsky, R., Evelhoch, J.L., Welch, M.J. and Hwang, DR. Characterization of 64Cu-DOTA-Conatumumab: A PET tracer for in vivo imaging of death receptor 5. J Nuc Med 52:942-949, 2011. 553. Shokeen, M., Pressly, E.D., Hagooly, A., Zheleznyak, A., Ramos, N., Fiamengo, A.L., Welch, M.J., Hawker, C.J. and Anderson, C.J. Evaluation of multivalent, functional polymericnanoparticles for imaging applications. ACS Nano 5(2):738-747, 2011. Book Chapters 1. Urch, D.S. and Welch, M.J.: Quantitative studies of the reactions of hot tritium atoms with hydrocarbons and hydrocarbon mixtures. In Chemical Effects of Nuclear Transformations, Vol. 1, IAEA, Vienna, Austria, 1975, pp 71-82. 2. Welch, M.J.: The role of the chemist in nuclear medicine. In The Year Book of Nuclear Medicine, J. Quinn, III (ed), 1969, p 6. 3. Ter-Pogossian, M.M., Eichling, J.O., Davis, D.O. and Welch, M.J.: The simultaneous measure in vivo of regional cerebral blood flow and regional cerebral oxygen utilization by means of xyhemoglobin labeled with radioactive oxygen-15. In Cerebral Blood Flow, M. Brock (ed) Springer Verlag, Berlin, Germany, 1969, p 66. 59 4. Welch, M.J.: Preparation of radioisotopes for biomedical studies using photonuclear reactions. In Proceedings of the International Conference on Photonuclear Reactions, B.L. Berman (ed), U.S.A.E.C. CONF-730301, Asilomar, California, 1973, pp 1179-1184. 5. Welch, M.J.: Choice and preparation of radioactive gasses. In Progress in Nuclear Medicine, Vol 3, Regional Pulmonary Function in Health and Disease, J. Lindeman, and B.C. Holman, S. Karger (eds), Baltimore, MD, 1973, pp 37-48. 6. Larson, K.B., Raichle, M.E., Phelps, M.E., Grubb, Jr., R.L., Welch, M.J., and TerPogossian, M.M.: Parameter estimation in the in vivo measurement of metabolic rates using externally monitored radiotracers. In Information Processing in Scintigraphy, C.E. Metz, S.M. Pizer, G.L. Brownell (eds), U.S.E.R.D.A. Publication 730687, 1975, pp 28-62. 7. Alderson, P., Krohn, K. and Welch, M: Radiopharmaceuticals. In Diagnostic and Nuclear Medicine, golden Diagnostic Radiology Section 20, Gottschalk and Potchen (eds.), 1976, pp 26-46. 8. Welch, M.J. and Welch, T.J.: Solution chemistry of carrier free indium. In Radiopharmaceuticals, G. Subramanian, B.A. Rhodes, J.F. Cooper, V.J. Sodd, (eds), The Society of Nuclear Medicine, New York, NY, 1975, pp 73-79. 9. Welch, M.J. and Krohn, K.K.: Critical review of radiolabeled fibrinogen: Its preparation and use. Ibid, New York, NY, 1975, pp 493-502. 10. Knight, L., Krohn, K.A., Welch, M.J., Spomer, B. and Hager, L.P.: Bromine-77: A new protein label. Ibid, New York, NY, 1975, pp 149-154. 11. Welch, M.J., Eichling, J.O., Straatmann, M.G., Raichle, M.E. and Ter-Pogossian, M.M.: New short-lived radiopharmaceuticals for CNS studies. In Non Invasive brain Imaging Computed tomography and Radionuclides, H.J. DeBlanc, J.A. Sorenson (eds), Society of Nuclear Medicine, New York, NY, 1975, pp 25-44. 12. Raichle, M.E., Eichling, J.O., Straatmann, M.G., Welch, M.J., Larson, K.B. and TerPogossian, M.M.: Blood-brain barrier permeability of 11C-labeled alcohols and 150-labeled water. Presented at the Seventh International Symposium on Cerebral Blood Flow and Metabolism, Aviemore, Scotland, 1975. In Blood Flow and Metabolism in the Brain, A.M. Harper, B. Jennet, D. Miller, and J. Rowan (eds), Churchill Livingstone, New York, NY, 1975, pp 520-521. 13. Ter-Pogossian, M.M., Hoffman, E.J., Weiss, E.S., Coleman, R.E., Phelps, M.E., Welch, M.J. and Sobel, B.E.: Positron emission reconstruction tomography for the assessment of regional myocardial metabolism by the administration of substrates labeled with cyclotronproduced radionuclides. In Proceedings of Conference on Cardiovascular Imaging and Image Processing: Ultrasound Angiography and Isotopes, Society of Photo-optical Instrumentation Engineers, Palos Verdes Estates, California, 1975, pp 277-282. 14. Weiss, E.S., Welch, M.J., Ter-Pogossian, M.M., Higgins, C.S. and Sobel, B.E.: Noninvasive quantification of myocardial infarction with positron emission transaxial tomography. In Computers in Cardiology, IEEE Computer Society, Long Beach, CA, 1976, pp 41-44. 15. Raichle, M.E., Welch M.J. and Ter-Pogossian, M.M.: Functional studies with emission computerized tomography. In Proceedings of the Conference on Computerized Tomography in Radiology, American College of Radiology, 1976, pp 133-141. 60 16. Raichle, M.E., Larson, K.B., Higgins, C.S., Grubb, R.L., Jr., Eichling, J.O., Welch, M.J. and Ter-Pogossian, M.M.: Three-dimensional mapping of brain metabolism and acid-base status. In CBF VIII, D.H. Ingvar and N.A. Lassen (eds) Munksgaard, Copenhagen, Denmark, 1977, pp 188-189. 17. Coleman, R.E., Harwig, J.F. and Welch, M.J.: Thrombus detection. In Current Concepts in Radiology. E. James Potchen (ed), C.V. Mosby Company, St. Louis, MO, 1977, pp 313-330. 18. Coleman, R.E., Welch, M.J. and Thakur, M.L.: Preparation and evaluation of leukocytes labelled with indium-III. In Medical Radionuclide Imaging, Vol. II, IAEA, Vienna, Austria, 1977, pp 47-51. 19. Welch, M.J. and Wagner, S.J.: Preparation of positron-emitting radiopharmaceuticals. In Recent Advances in Nuclear Medicine, Vol. 5, J.H. Lawrence and T.F. Budinger (eds) Grune & Stratton, 1978, pp 51-69. 20. Davis, H.H. and Welch, M.J.: Radioisotopic detection of arterial thrombi. In Venous and Arterial Thrombosis: Pathogenesis, Diagnosis, Prevention, and Therapy, J.H. Joist and L.A. Sherman (eds), Grune & Stratton, New York, NY, 1979, pp 295-303. 21. Gaspar, P.P. and Welch, M.J.: Inorganic hot-atom chemistry in gaseous and onecomponent liquid systems. In Chemical Effects of Nuclear Transformation in Inorganic Systems, G. Harbottle and A.G. Maddock (eds), North-Holland Publishing Co., Amsterdam, New York, Oxford, 1979, pp 77-101. 22. McElvany, K.D., Knight, L.C., Welch, M.J., Siuda, J.F., Theiler, R.F. and Hager, L.P.: Use of bromoperoxidase, an algal enzyme, in the preparation of radiobrominated proteins. In Marine Algae in Pharmaceutical Science, H.A. Hoppe, T. Levring and Y. Takaka (eds), Walter de Gruyter, Berlin, Germany, 1979, pp 429-446. 23. Welch, M.J. and Tewson, T.J.: Radiopharmaceuticals for neurological studies. In Radiopharmaceuticals II, Society of Nuclear Medicine, Seattle, WA, 1979, pp 201-217. 24. Sobel, B.E., Welch, M.J. and Ter-Pogossian, M.M.: Importance of electrophysiologic, enzymatic, and tomographic estimation of infarct size. In Cardiovascular Nuclear Medicine, H.W. Strauss, B. Pitt (eds), C.V. Mosby Co., St. Louis, MO, 1979, pp 173-187. 25. Welch, M.J. and Moerlein, S.R.: Radiolabeled compounds of biomedical interest containing radioisotopes of gallium and indium. In Inorganic Chemistry in Biology and Medicine, A.E. Martell (ed), A.C.S. Symposium Series No. 140, American Chemical Society, Washington, D.C., 1980, pp 121-140. 26. Welch, M.J. and Mathias, C.J.: Platelet viability following indium-111 oxine labeling in electrolyte solutions. In Indium-111 Labeled Neutrophills, Platelets, and Lymphocytes, M.L. Thakur and A. Gottschalk (eds), Trivirum Publ. Co., New York, NY, 1981, pp 93-100. 27. Welch, M.J., Mathias, C.J. and Siegel, B.A.: Clinical experience with indium-111 labeled platelets. Ibid, pp 171-176. 28. Welch, M.J., Wittmer, S.L., Dence, C.S. and Tewson, T.J.: Radiopharmaceuticals labeled with 11C and 18F. Considerations related to the preparation of 11C-Palmitate. In Advances in Chemistry Series, No. 197 Short-Lived Radionuclides in Chemistry and 61 Biology, J.W. Root and K.A. Krohn (eds), American Chemical Society, Washington, D.C., 1981, pp 407-417. 29. Bergmann, S.R., Mathias, C.J., Sobel, B.E. and Welch, M.J.: Evaluation of thrombolytic therapy in coronary artery thrombosis: Scintigraphic detection with the use of In-111-labeled platelets. In Nuclear Medicine and Biology, Vol 1, C Raynaud (ed), Pergamon Press, Paris, France, 1982, pp 65-68. 30. Powers, W.J., Mathias, C.J., Hopkins, K.T., Siegel, B.A. and Welch, M.J.: Dual radiotracer technique for improved scientigraphic detection of thrombi. Ibid, pp 2377-2380. 31. Welch, M.J., McElvany, K.D. and Tewson, T.J.: Production of high specific activity compounds labeled with short-lived radionuclides. In Receptor-Binding Radiotracers, Vol I, W.C. Eckelman and L.G. Colombetti (eds), CRC Press Inc., Boca Raton, FL, 1982, pp 5567. 32. Mathias, C.J. and Welch, M.J.: 111In-Labeled platelets for the detection of vascular disorders in animal models. In Animal Models for Radiotracer Design, R.M. Lambrecht and W.C. Eckelman (eds), Springer Verlag, New York, NY, 1983, pp 149-177. 33. Welch, M.J. and Kilbourn, M.R.: Positron emitters for imaging. In Freeman and Johnson’s Clinical Radionuclide Imaging (3rd Edition). Grune and Stratton, New York, NY, 1984, pp 181-202. 34. Mathias, C.J. and Welch, M.J.: Evaluation of animal models using In-111-labeled platelets. In Radiolabeled Cellular Blood Elements, M.L. Thaker (ed), Plenum Publishing Corp., New York, NY, 1985, pp 89-110. 35. Welch, M.J. and Kilbourn, M.R.: Radiopharmaceuticals for positron emission tomography. In Radionuclide Imaging of the Brain, B.L. Holman (ed), Churchill Livingston, New York, NY 1985, pp 27-38. 36. Welch, M.J. and Kilbourn, M.R.: Clinical potential of positron-emitting radiopharmaceuticals. In Radiopharmaceuticals: Progress and Clinical Perspectives, Vol II, A.R. Fritzberg (ed), CRC Press, Boca Raton, FL, 1985, pp 115-126. 37. Green, M.A. and Welch, M.J.: Gallium radiopharmaceutical chemistry. In Radiopharmaceutical Chemistry, A.G. Jones and M.J. Welch (eds), Martinus Nijhoff, The Hague. 38. Raichle, M.E., Mintun, M.A., Kilbourn, M.R. and Welch, M.J.: Study of the dopamine receptor pharmacokinetics with 18F-spiperone. In The Metabolism of the Human Brain Studied with Positron Emission Tomography, T. Greitz, D.H. Ingvar and L. Widen (eds), Raven Press, New York, NY, 1985, pp 269-272. 39. Kilbourn, M.R., Dence, C.S., Lechner, K.A. and Welch, M.J.: Quality assurance of short half-life radiopharmaceuticals. In Quality Assurance of Pharmaceuticals Manufactured in the Hospital, A. Warbick-Cerone and L.G. Johnston (eds), Pergamon Press, New York, NY, 1985, pp 243-250. 40. Broadack, J.W., Kilbourn, M.R., Welch, M.J. and Katzenellenbogen, J.A.: Application of robotics for the routine production of fluorine-18-labeled radiopharmaceuticals. In Advances in Laboratory Automation Robotics, J.R. Strimaitis and G.L. Hawk (eds), Zymark Corp., Hopkinton, MA, 1985, pp 663-676. 62 41. Mathias, C.J. and Welch, M.J.: Dual isotope scintigraphy for the detection of platelet deposition. In Platelet Kinetics and Imaging. Vol 1 Techniques and Normal Platelet Kinetics, A. du P. Heyns, P.N. Badenhorst and M.G. Lotter (eds), CRC Press Inc., Boca Raton, FL, 1985, pp 90-100. 42. Kilbourn, M.R., Welch, M.J., Dence, C.S. and Lechner, K.R.: From cyclotron to patient via HPLC. In Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry, D.M. Wieland, M.C. Tobes and T.J. Manger (eds), Springer-Verlag, New York, NY, 1986, pp 251-260. 43. Welch, M.J., Dence, C.S. and Kilbourn, M.R.: Problems in labeling receptor ligands and related compounds with positron emitting radionuclides. In Biomedical Imaging, O. Hayaishi and K. Torizuka (eds), Academic Press, Tokyo, Japan 1986, pp 375-386. 44. Brodack, J.W., Kilbourn, M.R., Welch, M.J. and Katzenellenbogen, J.A.: Automation in the PET radiopharmaceutical laboratory: a robot for the production of several short-lived positron-emitting radiopharmaceuticals. In Advances in Laboratory Automation Robotics 1986, J.R. Strimaitis & G.L. Hawk (eds), Zymark Corp., Hopkinton, MA, 1986, pp 333-346. 45. Welch, M.J. and Kilbourn, M.R.: Potential labeling of monoclonal antibodies with positron emitters. In Radiolabeled Monoclonal Antibodies for Imaging and Therapy, S.C. Srivastava (ed), Plenum Press, New York, NY, 1988, pp 261-267. 46. Welch, M.J., Siegel, B.A., Eichling, J.O. and Mathias, C.J.: Low-level radioactive waste at university medical centers. In Low-Level Radioactive Waste Regulation: Science, Politics, and Fear, M.E. Burns (ed), Lewis Publishers, Chelsea, MI, 1988, pp 109-117. 47. Otsuka, F.L. and Welch, M.J.: Use of an animal model system for evaluating labeled monoclonal antibodies. In Radiolabeled Monoclonal Antibodies for Imaging and Therapy, S.C. Srivastava (ed), Plenum Publishing Corp, New York, NY, 1988, pp 343-361. 48. Eckelman, W.C., Tweedle, M. and Welch, M.J.: NMR enhancement with Gd-labeled antibodies. In Radiolabeled Monoclonal Antibodies for Imaging and Therapy, S.C. Srivastava (ed), Plenum Publishing Corp, New York, NY, 1988, pp 571-579. 49. Schwarz, S.W. and Welch, M.J.: Radiolabeled antibodies: Introduction and metal conjugation techniques. In Applications of Enzyme Biotechnology, J.W. Kelly and T.O. Baldwin (eds), Plenum Press, New York, NY, 1991, pp 1-13. 50. Welch, M.J. and Shaikh, A.M.: Radiopharmaceuticals for cardiac positron emission tomography. In Positron Emission Tomography of the Heart, S.R. Bergmann and B.E. Sobel (eds), Futura Publishing Inc., Mount Kisco, NY, 1991, pp 77-96. 51. Shefer, R.E., Klinkowstein, R.E., Hughey, B.J. and Welch, M.J.: Production of PET radionuclides with a high current electrostatic accelerator. In Targetry ‘91, Proceedings of the IVth International Workshop on Targetry and Target Chemistry, Paul Scherrer Institut, 1992, Villigen, Switzerland, pp 4-10. 52. Hughey, B.J., Shefer, R.E., Klinkowstein, R.E. and Welch, M.J.: Design considerations for foil windows for PET radioisotope targets. Ibid, Villigen, Switzerland, 1991, pp 11-18. 53. Gaehle, G.G. and Welch, M.J.: Improved automated systems for the production of radiopharmaceuticals. Ibid, pp 186-189. 63 54. Sensui, Y. and Welch, M.J.: Hot atom chemistry of nitrogen. In Handbook of Hot Atom Chemistry, J.-P. Adloff, P.P. Gaspar, M. Imamura, A.G. Maddock, T. Matsuura, H. Sano and K. Yoshihara (eds), Kodansha, Tokyo, 1992, pp 105-113. 55. Anderson, C.J. and Welch, M.J.: Gallium. In Handbook on Metals in Clinical and Analytical Chemistry, H.G. Seiler, A. Sigel and H.Sigel (eds), Marcel Dekker, Inc., Basel, Switzerland, 1994, pp 372-380. 56. Anderson, C.J., Schwarz, S.W. and Welch, M.J.: Indium. Ibid, Basel, Switzerland, 1994, pp 401-408. 57. Welch, M.J., Downer, J.B. and Katzenellenbogen, J.A.: Steroid hormone receptors as targets for diagnostic imaging. In Current Directions in Radiopharmaceutical Research and Development, S.J. Mather (ed.), The Netherlands, 1996, pp 137-156. 58. Rowland, D.J., McCarthy, T.J. and Welch, M.J.: Radiobromine for imaging and therapy. In Handbook of Radiopharmaceuticals, M.J. Welch and C.S. Redvanly(eds), John Wiley & Sons, Chichester, England, 2002, pp 441-465. 59. Lewis, J.S. and Welch, M.J.: Copper chemistry related to radiopharmaceutical production. In Tc Chem. Nucl. Med. 6. SGE Editoriali, Italy, 2002, pp 23-33. 60. Vāvere, A.L., Lewis, J.S. and Welch, M.J.: Imaging of anti-angiogenic treatments: Ti45-transferrin microPET as a surrogate marker for tumor response. In Tc Chem. Nucl. Med. 6. SGE Editoriali, Italy, 2002, pp 101-105. 61. Bigott, H.M. and Welch, M.J.: Technetium-94m-sestamibi. Preparation & quality control for human use. In Tc Chem. Nucl. Med. 6. SGE Editoriali, Italy, 2002, pp 559-561. 62. McQuade, P., McCarthy, D.W. and Welch, M.J.: Metal radionuclides for PET imaging. In Positron Emission Tomography, P.E. Valk, D.L. Bailey, D.W. Townsend and M.N. Maisey (eds), Springer-Verlag, London, UK, 2003, pp 251-264. 63. Schwarz, S., Gaehle, G.G. and Welch, M.J.: Accelerators and positron emission tomography (PET) radiopharmaceuticals. In Diagnostic Nuclear Medicine, M.P. Sandler, R.E. Coleman, J.A. Patton, F.J. Th. Wackers, and A. Gottschalk (eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2003, pp 117 – 131. 64. Dence, C.S., Herrero, P., Schwarz, S.W., Mach, R.H., Gropler, R.J. and Welch, M.J.: Imaging Myocardium Enzymatic Pathways with Carbon-11 Radiotracers. In Methods in Enzymology, P.M. Conn (ed), Academic Press, Oregon, 2004, pp 286-315. 65. Shiue, C-Y. and Welch, M.J.: Update on PET radiopharmaceuticals: Life beyond fluorodeoxyglucose. In Radiologic Clinics of North America, A. Alavi (ed), W. B. Saunders, 2004, pp 1033-1053. 66. Urch, D.S. and Welch, M.J.: Radiochemistry and radiopharmaceuticals. In Annu Rep Prog Chem, Sect A, 101, The Chemical Society, London, England, 2005, pp 585-606. 67. Rossin, R. and Welch, M.J.: Molecular Imaging Probes for PET and SPECT. In Molecular Imaging of the Lungs, D. P. Schuster and T.S. Blackwell (eds), Taylor and Francis, New York, NY, 2005, pp 3-39. 64 68. Rossin, R. and Welch, M.J.: Radiometals for molecular imaging, other than technetium. In Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 7, U. Mazzi (ed), Servizi Grafici Editoriali, Padova, Italy, 2006, pp 173-188. 69. Rossin, R., Pressly, E., Fukukawa, K., Messmore, B., Turner, J.L., Joralemon, M.J., Becker, M.L., Hawker, C., Wooley, K.L. and Welch, M.J.: Evaluation of 64 Cu-Radiolabeled Nanoparticles for the diagnosis and treatment of disease. In Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 7, U. Mazzi (ed), Servizi Grafici Editoriali, Padova, Italy, 2006, pp 223-226. 70. Rossin, R., Azhdarinia, A., Mendez, R., Oh, D., Yang, D.J. and Welch, M.J.: Evaluation of commercially available 68Ge/68Ga-generators for the synthesis of high specific activity 68 Ga-radiotracers. In Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 7, U. Mazzi (ed), Servizi Grafici Editoriali, Padova, Italy, 2006, pp 239 -240. 71. Welch, M.J., Laforest, R. and Lewis, J.S.: Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. In PET Chemistry, The Driving Force in Molecular Imaging, P.A. Schubiger, L. Lehmann and M. Friebe (eds), Springer, London, UK, 2006, pp 159-181. 72. Welch, M.J.: Quantitative Cardiac PET in Small Animals: Technical Aspects. In Cardiovascular Molecular Imaging, R.J. Gropler, D. Glover, A.J. Sinusas and H. Taegtmeyer (eds), Taylor and Francis, New York, NY, 2007, pp 151-160. 73. Hagooly, A., Rossin, R. and Welch, M.J.: Small Molecule Receptors as Imaging Targets. In Molecular Imaging II. W. Semmler and M. Schwaiger (eds), Springer-Verlag Berlin Heidelberg, Germany, 2008, pp 93-129. Books Published: 1. Welch, T.J., Potchen, E.J. and Welch, M.J.: Introduction to the Tracer Methods: For Students in Biology and Medicine, Saunders Publishing Company, Philadelphia, PA, 1972. 2. Welch, M.J.: Radiopharmaceuticals and Other Compounds Labelled with Short-lived Radionuclides, Pergamon Press, Oxford, 1977. 3. Welch, M.J. and Redvanly, C.S.: Handbook of Radiopharmaceuticals, Wiley, Chichester, England, 2002. 4. Welch, M.J., Lewis, J.S. and Tang, L.: Proceedings of a Workshop on the production, application and clinical translation of “non-standard” PET nuclides: a meeting report, The Quarterly Journal of Nuclear Medicine and Molecular Imaging, Edizioni Minerva Medica, Turin, Italy, Vol.52, N.02, 2008. 65
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