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LB145 PyruvateProcessing and TheCitricAcidCycle YouShouldBeAbleTo… 1. Describehowpyruvateisconvertedinto AcetylCoA. 2. DrawasimplifiedversionoftheCitricAcid Cycle. 3. Identifyanddescribetheendergonic reactionsthatoccurduringtheoxidationof pyruvate. Campbell:Fig.9-6-3 Electronscarried viaNADHand FADH2 Electrons carried viaNADH Citric acid cycle Glycolysis Pyruvate Glucose Oxidative phosphorylation: electrontransport and chemiosmosis Mitochondrion Cytosol ATP ATP ATP Substrate-level phosphorylation Substrate-level phosphorylation Oxidative phosphorylation PyruvateProcessing PyruvateProcessing • Pyruvateprocessingisthesecondstepin glucoseoxidation.Itiscatalyzedbythe enzymepyruvatedehydrogenase inthe mitochondrialmatrix. • InthepresenceofO2,pyruvateundergoesa seriesofreactionsthatresultsintheproduct moleculeacetylcoenzymeA(acetylCoA). Fig.9-10 CYTOSOL MITOCHONDRION NAD+ NADH +H+ 2 1 Pyruvate Transportprotein 3 CO2 CoenzymeA AcetylCoA PyruvateProcessingRegulation Pyruvatedehydrogenase mediatesthe productionofAcetyl-CoA Inhibition: AbundantATPreservesinhibittheenzyme complex. TheCitricAcidCycle Campbell:Fig.9-6-3 Electronscarried viaNADHand FADH2 Electrons carried viaNADH Citric acid cycle Glycolysis Pyruvate Glucose Oxidative phosphorylation: electrontransport and chemiosmosis Mitochondrion Cytosol ATP ATP ATP Substrate-level phosphorylation Substrate-level phosphorylation Oxidative phosphorylation CitricAcidCycle/KrebsCycle TheCitricAcidCycleandtheKrebsCyclearethe SAMETHING. Fig.9-11 Pyruvate CO2 NAD+ CoA NADH +H+ AcetylCoA CoA CoA Citric acid cycle FADH2 2 CO2 3NAD+ 3 NADH FAD +3H+ ADP+ P i ATP NADPH YouShouldBeAbleTo… 1. Describehowpyruvateisconvertedinto AcetylCoA. 2. DrawasimplifiedversionoftheCitricAcid Cycle. 3. Identifyanddescribetheendergonic reactionsthatoccurduringtheoxidationof pyruvate. LB145
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