Download Pharmaceutical Industry Product Catalog

Business Unit
Performance Materials
Innovative materials
for the pharmaceutical industry
Business Line
Pharmaceutical Industry
India
Think Asia. Think DKSH.
Ashland Inc., USA
Products
Generic name
Characteristics
Application
Polyplasdone XL (Type A)
Crospovidone
Conventional particle size grade
Used as a disintegrant for IR tablets
Polyplasdone XL-10 (Type B)
Fine particle size grade
Used as a disintegrant for ODT and
provides smooth mouth feel
Polyplasdone INF-10 (Type B)
Very fine particle size grade
Used as a suspending agent in oral
suspension and also used as a disintegrant for pellets and MUPS
Polyplasdone Ultra (Type A)
Low peroxide content grade with
conventional particle size
Used as a disintegrant for IR tablets
containing oxidation sensitive API
Polyplasdone Ultra-10
(Type B)
Low peroxide content grade with
fine particle size
Used as a disintegrant for ODT
containing oxidation sensitive API
Grade differentiation based on
viscosity and K value
Used as binder and vehicle for soft
gelatin capsules and for drug solubilization
Plasdone K-12
Plasdone K-17
Povidone/PVP
Used as a binder for wet/dry granulation in tablets, capsules, pellets and
powders
Plasdone K-25
Plasdone K-29/32
Plasdone K-90
Plasdone K-90D
Plasdone C-12
Plasdone C-17
Plasdone C-30
Pyrogen free grade
Used as solublizer and suspension
stabilizer for parenterals and ophthalmic formulations
Plasdone S-630
Copovidone
–
• Plasdone S-630 is a binder and
matrix polymer for solid dispersion
formulations
• It is used to enhance solubility of
poorly soluble drugs through melt
extrusion or spray dried solid
dispersion
Klucel HF, HXF Pharm
Hydroxypropyl
cellulose (HPC)
Grade differentiation based on
Viscosity
‘X' stands for fine particle size
Used as a release retardant in CR
Tablets and thickener for semisolids
Klucel MF, MXF Pharm
Klucel GF, GXF Pharm
Klucel JF, JXF Pharm
Klucel LF, LXF Pharm
Klucel EF, EXF Pharm
Klucel ELF Pharm
Used as a release retardant in CR
Tablets and binder for solid oral
formulations
• Conventional grades used as binder for wet granulation and fine
particle grade is used for dry granulation and direct compression
• Used in film coating system
• Low molecular weight Klucel used
in melt extrusion
2
Ashland Inc., USA (Cont‘d)
Products
Generic name
Characteristics
Application
Benecel E4M Pharm*
Benecel E10M Pharm*
Hydroxypropyl
methylcellulose/
Hypromellose
(2910 substitution/
E Type)
–
• These grades can be used as
hydrophilic release retardant for
CR tablets
• Can also be used as a thickening
agent to help prevent or minimize
suspension settling without
altering taste or mouth feel in
liquid suspensions
Benecel K100 LV PH PRM**
Benecel K250 PH PRM**
Benecel K750 PH PRM**
Benecel K1500 PH PRM**
Benecel K4M Pharm*
Benecel K4M PH DC
Benecel K15M Pharm*
Benecel K15M PH DC
Benecel K35M Pharm*
Benecel K100M Pharm*
Benecel K100M PH DC
Benecel K200M Pharm*
Hydroxypropyl
methylcellulose/
Hypromellose
(2208 substitution/
K Type)
Differentiation based on viscosity
'DC' stands for direct compressible grade
• These grades can be used in single
or in combination intragranularly
or extragranularly as hydrophilic
release retardant for CR tablets
• DC grades are used as direct
compressible release retardant
Methylcellulose
Differentiation based on viscosity
Benecel Methylcellulose used as granulating agent and thickener. Low
viscosity Benecel A15 LV is commonly
used in drug layering
Benecel ME 233 P Pharm
Methylhydroxyethyl
cellulose
–
It can be used as binder in solid orals
and as rheology modifier in liquid
orals and topicals
Aquarius Preferred HSC
Ready-mix coating
system
–
High-solids coatings based on cellulosic polymers
* CR grades available, ** Only CR grades available
Benecel A15 LV PH PRM
Benecel A15C Pharm
Benecel A4M Pharm
Aquarius Preferred HSP
High-solids coatings based on copovidone with cellulosic polymers for
significant improvements in adhesion
and sprayable solids
Aquarius Prime
Coatings based on traditional cellulosic polymers
Aquarius Prime LS
Coatings based on cellulosic polymer
and lactose
Aquarius Preferred MG
This coating system reduces the moisture uptake
3
Ashland Inc., USA (Cont‘d)
Products
Generic name
Characteristics
Application
Aquarius Preferred TG
Ready-mix coating
system
–
This coating system masks the unpleasant taste of tablet
Aquarius Preferred OG
This coating system masks the unpleasant odour of tablet
Aquarius Control ENA
Delayed-release (enteric) coatings
based on methacrylic acid-ethyl acrylate copolymer
Aquarius Control SRX
Sustained release coatings based on
ethylcellulose
Blanose 7H4XF PH
Blanose 7HF PH
Blanose 7H3SF PH
Blanose 7HOF PH
Blanose 7M31F PH
Blanose 7M8SF PH
Blanose 7MF PH
Blanose 7M1F PH
Blnaose 7LF PH
Blanose 9H4XF PH
Blanose 9M31F PH
Blanose 12M31P
Blanose 12M8P
Sodium CMC/
Carmellose sodium
Differentiation based on viscosity
and degree of substitution
• Used as a thickener/viscosity
modifier in liquid orals/semi-solids
• Also used as a binder and release
retardant for CR tablets
Aqualon 7HF PH
Aqualon 7H3SF PH
Aqualon 7MF PH
Aqualon 7M8SF PH
Aqualon 7LF
Aqualon 7L2P
Aqualon 9M31F PH
Aqualon 9M8F PH
Aqualon 12M31P
Sodium CMC/
Carmellose sodium
Differentiation based on viscosity
and degree of substitution
• Used as a thickener/viscosity
modifier in liquid orals/semi-solids
• Also used as a binder and release
retardant for CR tablets
Aqualon EC T10 Pharm
Ethyl cellulose
Differentiation based on viscosity
Used as a binder in direct compression
due to its good flow and compactability
Aqualon EC N7 Pharm
Aqualon EC N10 Pharm
Aqualon EC N14 Pharm
Aqualon EC N22 Pharm
Aqualon EC N50 Pharm
Aqualon EC N100 Pharm
Used for coating powder, granules
and pellets to control drug release.
Also used in seal coating
4
Ashland Inc., USA (Cont‘d)
Products
Generic name
Characteristics
Application
Natrosol 250 HHX/HHW
Pharm
Natrosol 250 HX Pharm,
H Pharm
Natrosol 250 M Pharm
Natrosol 250 G Pharm
Natrosol 250 L Pharm
Hydroxyethyl
cellulose
Differentiation based on viscosity
'X' stands for fine particle size
• Used as a viscosity modifier in
liquid orals and semi-solids
• Also used as release retardant in
CR tablets
Aquasolve L
Hypromellose
acetate
succinate/HPMCAS
Dissolves at pH more than 5.8
Used as an enteric coating agent and
as a solublizer for poorly soluble API in
spray dried solid dispersions and hot
melt extrusion
Aquasolve M
Aquasolve H
Dissolves at pH more than 6.0
Dissolves at pH more than 6.8
Cavamax W6 Pharma
a-cyclodextrin
Oral grade
• Used to enhance solubility of
poorly soluble drugs in solid
dispersions
• Used to mask unpleasant odour/
taste of API and to stabilize the
same
Cavamax W7 Pharma
b-cyclodextrin
Cavamax W8 Pharma
g-cyclodextrin
Cavasol W7 HP Pharma
Hydroxypropyl
b-cyclodextrin
Cavasol W8 HP Pharma
Hydroxypropyl
g-cyclodextrin
Cavitron W7 HP5 Pharma
Cavitron W7 HP7 Pharma
Hydroxypropyl
b-cyclodextrin
Parenteral grade
Used to increase solubility of drug in
Parenterals
Pharmasolve
N-methyl-2pyrrolidone
–
Used as solubilizer and penetration
enhancer in parenterals and topicals
Products
Generic name
Characteristics
Application
Cellucrest 101
Microcrystalline
cellulose
Conventional particle size grade
Conventional grade for wet and dry
granulation
Cellucrest 102
Coarser particle size
Filler for direct compression. Improves
flow property and compressibility
Cellucrest 112
Low moisture, coarser particle
size
Filler for direct compression of moisture sensitive product
Cellucrest 113
Low moisture, fine particle size
Improves stability of moisture sensitive product
Crest Cellulose Pvt. Ltd., India
5
Crest Cellulose Pvt. Ltd., India (Cont‘d)
Products
Generic name
Characteristics
Application
Cellucrest 200
Microcrystalline
cellulose
Largest particle size
Improves flow of blend for direct compression and dry granulation. Also
reduces weight variation and variation
in content uniformity
Cellucrest 301
High bulk density grade
To achieve efficient mixing of blend to
manufacture small tablets and reduces weight variation and variation in
content uniformity
Cellucrest 302
High bulk density grade with
coarser particle size
To achieve efficient mixing of blend to
manufacture small tablets and reduces weight variation and variation in
content uniformity
Rapigel
Sodium starch
glycolate
–
Used as a disintegrant for IR tablets,
capsules and ODT
Lubricrest
Magnesium stearate
–
Lubricant
Crestcross
Croscarmellose
sodium
–
Used as a disintegrant for IR tablets,
capsules and ODT
Crestadd
Dicalcium phosphate
anhydrous/
Dicalcium phosphate
dihydrate
–
Used as a filler in wet granulation
Gelmac
Pregelatinized maize
starch
–
Used as a binder
Products
Generic name
Characteristics
Application
Flavor (Liquid form)
Natural flavor
Nature identical
flavor
Synthetic flavor
–
Flavoring agent for liquid orals
Symega Flavours, India
Spray Dried Flavor (Powder
form)
Flavoring agent for ODT, effervescent
powder, granules and tablets
Unique combinations for bitter taste
masking
Bitter Taste Masker
Functional Flavor
–
–
Delivery of nutraceutical actives for
gut health
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Stepan, USA
Products
Generic name
Characteristics
Application
Stepanol WA 100
Sodium lauryl
sulphate
Oral grade, needle like crystals
Used as a wetting agent in tablets,
liquid orals and semi-solids
Mondo Minerals B.V., Netherlands
Products
Generic name
Characteristics
Application
Microtalc Pharma 50
Talc/Hydrated
Magnesium Silicate
Standard Particle Size grade
Used as an antiadherant for tablets
Fine particle size grade
Very fine particle size grade
Used for drug layering in pellets and
also used as anti tacking agent in film
coating system
Microtalc Pharma 30
Microtalc Pharma 8
JMC Corporation, Korea
Products
Generic name
Characteristics
Application
Sodium saccharin, 15%
moisture
Sodium saccharin, 6%
moisture
Sodium saccharin
–
Used as a sweetner in powder, granules, ODT and liquid orals
Products
Generic name
Characteristics
Application
Pretiox AV 01 PhG
Titanium dioxide
–
Used as an opacifier in capsule shell
and color coating system
Precheza A.S., Czech Republic
7
Freund Corporation, Japan
Products
Generic name
Characteristics
Application
Dilactose R
Dilactose F
Dilactose S
Lactose
monohydrate
(Granulated)
Grade differentiation based on
particle size
Used in direct compression formulations to provide good flow and superior compressibility. Tablets manufactured with Dilactose provides quick
disintegration
Products
Generic name
Characteristics
Application
GNF-D211
GNF-D215
Co-Processed
excipient (D-Mannitol, Microcrystalline cellulose,
Crospovidone,
Carboxymethyl
cellulose)
–
Co-processed excipient for ODT
Products
Generic name
Characteristics
Application
Kimica Acid SN
Alginic acid
Complying NF (National Formulary)
Complying to EP and BP
Used as a disintegrant in anti-reflux
and effervescent tablets
Kimica Algin ULV-L3
Kimica Algin ULV-L5
Kimica Algin ULV-1
Kimica Algin ULV-3
Kimica Algin ULV-5
Sodium alginate
Ultra low viscosity sodium alginate
Used as a gelling agent in anti-reflux
suspensions and effervescent tablets
Kimica Algin IL-2
Kimica Algin IL-6
Kimica Algin I-1
Kimica Algin I-3
Kimica Algin I-5
Kimica Algin I-8
Kimica Algin I-S
Sodium alginate
Standard type sodium alginate
Used in controlled release formulations
Daicel Corporation, Japan
Kimica Corporation, Japan
Kimica Acid SEB
8
Kimica Corporation, Japan (Cont‘d)
Products
Generic name
Characteristics
Application
Kimica Algin LZ-2
Sodium alginate
Ultra high viscosity sodium alginate
Used in controlled release formulations
Kimica Algin ULV-1G
Kimica Algin ULV-5G
Kimica Algin IL-6G
Kimica Algin I-1G
Kimica Algin I-3G
Sodium alginate
High stiffness gelation type Sodium Alginate
Kimiloid LVC
Kimiloid HVC
Propylene glycol
alginate
Standard Type Propylene Glycol
Alginate
Kimiloid AB
Kimiloid LLV
Kimiloid NLS-K
Kimiloid LV
Kimiloid MV
Kimiloid HV
Used as a suspending agent, emulsion
stabilizer, plasticiser and binder
High esterification type Propylene Glycol Alginate
Kimica Algin K
Potassium alginate
–
Kimica Algin Ca
Calcium alginate
Gelling agent
Kimica Algin NH
Ammonium alginate
Dental impression material
Kimica Algin Mag
Magnesium alginate
Anti reflux suspensions for infants
Dental impression material
NOF Corporation, Japan
NOF CORPORATION
Products
Generic name
Characteristics
Application
Polysorbate 20
Polyoxyethylene
sorbitan monolaurate/Polysorbate 20
–
Used as a solublizer in parenterals
Polysorbate 80 GS
Polyyoxyethylene
Sorbitan monooleate/Polysorbate
80
Polysorbate 80 HX2
Sunbright DKH-02HB
PEG 200
Sunbright DKH-03HB
PEG 300
Sunbright DKH-04HB
PEG 400
Activated PEGs
Methoxy-polyethylene glycols (mPEGs)
Used as a solublizer in parenterals
High purity solubilizer for parenterals
Parenteral grade
Used as a solublizer in parenterals
–
Used for targeted drug delivery
system
9
NOF Corporation, Japan (Cont‘d)
NOF CORPORATION
Products
Generic name
Characteristics
Application
Phospholipids from Natural
Sources
HSPC (Hydrogenated
soyabean phosphatidylcholine
EPC (Egg phosphatidylcholine)
HEPC (Hydrogenated
egg phosphatidylcholine)
Egg sphingomyelin/
Milk sphingomyelin
–
Used in liposomes
Synthetic Phospholipids
Different derivatives
of phosphocholine
Different derivatives
of phosphatidylglycerol
Different derivatives
of phosphatidic acid,
sodium salts
Different derivatives
of phosphotidylethanolamine
Different derivatives
of phosphatidylserine
–
Used in liposomes
Products
Generic name
Characteristics
Application
Purified Egg Phospholipids PL
90
Purified egg
phospholipids
Parenteral grade
Used as an emulsifier in injectables
Products
Generic name
Characteristics
Application
Cavamax W8 - CoQ10
complex
Highly bioavailable
CoQ10
–
Cardiovascular health
Fresenius Kabi, Germany
Wacker Chemie AG, Germany
10
Wacker Chemie AG, Germany (Cont‘d)
Products
Generic name
Characteristics
Application
Cavacurcumin
Highly bioavailable
curcumin
–
Anticancer/antiinflammatory
HTEssence
Hydroxytyrosol
–
Antioxidant for Cardiovascular health/
skin lightening
Horphag Research, Switzerland
Products
Generic name
Characteristics
Application
Pycnogenol
French maritime
pine bark extract
–
• Cardiovascular health
– Improves endothelial function
– Normalises high blood pressure
• Diabetes
• Joint health
• Oral skin care/topical skin care
• Sports nutrition
• Erectile dysfunction
Robuvit
French oak extract
–
Chronic fatigue syndrome
Products
Generic name
Characteristics
Application
Polyglykol 300
Polyglykol 400
Polyglykol 600
Polyethylene glycols/
Macrogols
Brand name followed by numbers indicate the average molecular weight
The high solvent power leads to a
broad use of low molecular weight
PEGs in liquid preparations such as
drops, parenterals or fillings for
gelatin capsules
Polyglykol 1000
Polyethylene glycols/
Macrogols
–
Used to make ointment base
Lanogen 1500
Polyethylene glycols/
Macrogols
Ointment base (JP) containing
Polyglykol® 300 and 1500 in a
ratio of 1:1.
Used as an ointment base
Clariant, Switzerland
11
Clariant, Switzerland (Cont‘d)
Products
Generic name
Characteristics
Application
Polyglykol 1500 S
Polyglykol 2000 S
Polyglykol 3000 S/P
Polyglykol 3350 S/P/PS
Polyglykol 4000 S/P/PF/ PS
Polyglykol 6000 S/P/PF
Polyglykol 8000 S/P/PF
Polyglykol 10000 S/P
Polyglykol 12000 S/P
Polyglykol 20000 S/P
Polyglykol 35000 S
Polyethylene glycols/
Macrogols
Brand name followed by numbers indicate the average molecular weight
‘S' stands for flakes
'P' stands for powder
'PF' stands for fine powder
'PS' stands for spray dried
powder
• Solid PEGs are preferred bases for
suppository masses. PEGs can be
used as carriers, solubilizers and
absorption improvers for active
substances, usually processed in
the form of a melt (melt granulation)
• They also act as lubricants and
binders during tablet processing
• PEGs also has a plasticizing effect
which facilitates the shaping of the
tablet mass in the compression
process and may counteract
capping
• Solid PEGs are also frequently used
in tablet coatings as a plasticizer.
The flexibility of sugar-coated
tablets is increased by PEGs
The USP/NF describes a blend in
the monograph ‘PEG 3350 and
Electrolytes for Oral Solution’ as a
laxative preparations which contains a detailed description of all
potential individual salt components to be used in addition to the
polyglycol with a mean molecular
weight of 3350
Products
Generic name
Characteristics
Application
Farmal MN 5000
Mannitol
Standard oral grade
Used as a diluent for ODT and also
used in sugar free tablets
Injectable grade
Vehicle for lyophilised products
–
Used as a sweetner in powder,
granules, ODT and liquid orals
Ingredion, USA
Farmal MN 5010
Dulcent Aspartame
Aspartame
Dulcent Sucralose
Sucralose
Used as a sweetner in powder,
granules, ODT and liquid orals
12
Our core business
Pharmaceutical industry
We source and supply a wide range of
innovative, high-performance chemicals,
intermediates, API and formulations for
the pharmaceutical industry.
Sourcing
We source APIs, excipients, and intermediates from India as well as globally.
We provide
• Regulatory support
• Technical assistance
• Logistics, warehousing and
distribution
• Custom manufacturing
• Development services
• Quality assurance
Strengthen service offerings
We continually strengthen and expand our
range of service offerings across the entire
value chain. To ensure the long-term
success of our business partners, we
constantly deliver more value-added
solutions that give them a competitive
advantage.
Your preferred partner for sourcing
• Comprehensive sourcing network in
Asia, Europe and the Americas
• Proven track record
• Early trend scout
• Global technology transfers
• Highly dedicated team of sourcing
specialists
Increase operational efficiency
We continuously improve the efficiency of
our processes. The quality of our services is
based on best practices and standards
throughout our entire organization. An
efficient supply chain coupled with
synergies across all Business Units and
countries allow us to fulfill the diverse
requirements of the business we serve.
Our key sourcing offices
• Japan
• Korea
• China
• India
• Europe
The information in this brochure is to our best knowledge true and accurate but, all instructions, recommendations or suggestions are made without guarantee. Since the conditions
of use are beyond their control, DKSH disclaims any liability for loss or damage suffered for use of this data or suggestions. Furthermore, no liability is accepted if use of any product in
accordance with this data or suggestions infringes any patent.
13
Notes
14
15
Pharmaceutical industry
Branch locations
Ahmedabad
Phone +91 79 6543 9950
[email protected]
Kolkata
Phone +91 33 4060 5527
[email protected]
Delhi
Phone +91 11 2691 6320/21
[email protected]
Mumbai
Phone +91 22 6157 7000
[email protected]
DKSH India Private Limited
Fantree Building, Sarla Park, Andheri East, Mumbai 400059, India
Phone +91 22 6157 7000, Fax +91 22 2920 0210
[email protected], www.dksh.in
Secunderabad
Phone +91 40 6649 1011
[email protected]