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Downregulation of Bone Morphogenetic Protein Receptor
Axis During HIV-1 and Cocaine-Mediated Pulmonary
Smooth Muscle HyperplasiaSignificance
by Pranjali Dalvi, Amy O’Brien-Ladner, and Navneet K. Dhillon
Arterioscler Thromb Vasc Biol
Volume 33(11):2585-2595
October 16, 2013
Copyright © American Heart Association, Inc. All rights reserved.
Attenuation of transactivator of transcription (Tat) and cocaine mediated increased proliferation
of human pulmonary arterial smooth muscle cells (HPASMCs) on the activation of bone
morphogenetic protein (BMP)/BMP receptor (BMPR) axis.
Pranjali Dalvi et al. Arterioscler Thromb Vasc Biol.
2013;33:2585-2595
Copyright © American Heart Association, Inc. All rights reserved.
Increased bone morphogenetic protein receptor (BMPR)-2, BMPR-1A, and BMPR-1B mRNA
expressions in human pulmonary arterial smooth muscle cells (HPASMCs) on combined
treatment with transactivator of transcription (Tat) and cocaine.
Pranjali Dalvi et al. Arterioscler Thromb Vasc Biol.
2013;33:2585-2595
Copyright © American Heart Association, Inc. All rights reserved.
Decreased bone morphogenetic protein receptor (BMPR)-2, BMPR-1A, and BMPR-1B protein
levels on combined treatment with transactivator of transcription (Tat) and cocaine.
Pranjali Dalvi et al. Arterioscler Thromb Vasc Biol.
2013;33:2585-2595
Copyright © American Heart Association, Inc. All rights reserved.
Abrogation of bone morphogenetic protein receptor (BMPR)–mediated downstream signaling on
exposure of transactivator of transcription (Tat)–treated human pulmonary arterial smooth
muscle cells (HPASMCs) to cocaine.
Pranjali Dalvi et al. Arterioscler Thromb Vasc Biol.
2013;33:2585-2595
Copyright © American Heart Association, Inc. All rights reserved.
Increase in mRNA and decrease in protein expression of bone morphogenetic protein receptors
(BMPRs) in human lung tissues from HIV-infected intravenous drug users (IVDUs).
Pranjali Dalvi et al. Arterioscler Thromb Vasc Biol.
2013;33:2585-2595
Copyright © American Heart Association, Inc. All rights reserved.
Treatment of human pulmonary arterial smooth muscle cells (HPASMCs) with transactivator of
transcription (Tat) in the presence of cocaine results in greater reduction in bone morphogenetic
protein receptor (BMPR) protein expression when compared with that of the other HIV proteins.
Pranjali Dalvi et al. Arterioscler Thromb Vasc Biol.
2013;33:2585-2595
Copyright © American Heart Association, Inc. All rights reserved.
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