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Genotypes HH Hh hh XHXH XHXh XhXh XHY XhY Homozygous Dominant Heterozygous Dominant Homozygous Recessive Homozygous Dominant Female Heterozygous Dominant Female Homozygous Recessive Female Dominant Male Recessive Male A woman has the recessive disorder cystic fibrosis and marries a man without the disease. Determine the genotypic and phenotypic ratio of the children they plan to have. What are the chances of a child having cystic fibrosis from the couple? A woman and a man are both heterozygous for the dominant disorder Huntington’s disease. What are the chances of their children NOT having the disorder? Determining inheritance patterns of Pedigrees • Dominant inheritance– Trait appears in every generation – Many individuals have the trait • Recessive inheritance– Trait skips generations – Few individuals have the trait • Sex-linked inheritance– More males have the trait than females – Can be dominant or recessive What is the inheritance pattern of the following pedigree? What are the genotypes of individuals I-1 and I-2? What were the chances of I-1 and I-2’s children having the trait? What is the inheritance pattern of the following pedigree? What are the genotypes of I1 and I2? What are the chances of III3 and III4’s next child having the trait? • A woman is heterozygous for Type A blood and her husband has Type AB blood. What are the chances of their child having Type A blood? Type AB blood? Type O blood? Type B blood? • A man has the sex-linked, recessive trait redgreen colorblindness and his wife is a carrier for red-green colorblindness. What are the chances of their child having red-green colorblindness? What are the chances of their next girl having red-green colorblindness?