Download Table S2.

Table S2. GO categories upregulated in early acute phase vs convalescent phase(P < 0.05) (HG-focus
platform)
function
type I interferon-mediated signaling pathway
cytokine-mediated signaling pathway
response to virus
immune response
innate immune response
interferon-gamma-mediated signaling pathway
double-stranded RNA binding
chemotaxis
negative regulation of type I interferon
production
defense response to virus
inflammatory response
ISG15-protein conjugation
phagocytosis, engulfment
blood circulation
negative regulation of viral genome replication
response to biotic stimulus
positive regulation of interferon-alpha production
nucleosome
IgG binding
cellular copper ion homeostasis
superoxide-generating NADPH oxidase activity
cell-cell signaling
cellular response to heat
copper ion transport
nucleosome assembly
ISG15 ligase activity
regulation of defense response to virus
intracellular transport of viral proteins in host cell
cellular response to interferon-alpha
interleukin-1 beta secretion
detection of virus
RNA catabolic process
cytosol
modification-dependent protein catabolic
process
negative regulation of defense response to virus
by host
pathogen-associated molecular pattern
dependent induction by symbiont of host innate
immunity
tryptophan catabolic process to kynurenine
protein kinase inhibitor activity
microglial cell activation involved in immune
response
response to lipopolysaccharide
negative regulation of erythrocyte differentiation
tryptophan catabolic process
hydrolase activity, acting on acid anhydrides
positive regulation of immune response
chemokine activity
response to cold
positive regulation of tumor necrosis factor
biosynthetic process
JAK-STAT cascade
protein dimerization activity
defense response to bacterium
Enrichment
Score
48.1918
44.7086
27.706
22.0887
18.0716
18.0352
14.7506
13.1787
Enrichment pvalue
1.18E-21
3.83E-20
9.28E-13
2.55E-10
1.42E-08
1.47E-08
3.93E-07
1.89E-06
% genes in group # genes in list,
that are present
in group
33.3333
21
18.4932
27
16.3636
18
8.48057
24
8.7156
19
17.4603
11
25.9259
7
11
11
10.6409
10.5916
10.0085
9.7455
9.7455
9.60189
9.27546
9.06589
9.06589
8.65279
8.5198
8.06331
7.67135
7.65048
7.02319
7.02319
7.01185
6.92111
6.92111
6.92111
6.92111
6.92111
6.92111
6.50007
6.27649
2.39E-05
2.51E-05
4.50E-05
5.86E-05
5.86E-05
6.76E-05
9.37E-05
0.000115541
0.000115541
0.000174639
0.00019948
0.000314883
0.00046599
0.000475818
0.00089098
0.00089098
0.000901144
0.000986732
0.000986732
0.000986732
0.000986732
0.000986732
0.000986732
0.00150334
0.00187999
25
18.1818
6.80628
60
60
15.3846
28.5714
50
50
13.0435
42.8571
37.5
33.3333
5.6872
27.2727
27.2727
9.67742
66.6667
66.6667
66.6667
66.6667
66.6667
66.6667
23.0769
2.80496
5
6
13
3
3
6
4
3
3
6
3
3
3
12
3
3
6
2
2
2
2
2
2
3
43
6.24007
0.00194972
50
2
6.24007
0.00194972
50
2
6.24007
6.24007
6.06264
0.00194972
0.00194972
0.00232824
50
50
20
2
2
3
5.74133
5.48064
5.34793
5.34793
5.34793
5.02351
4.87244
4.81069
0.0032105
0.00416668
0.00475797
0.00475797
0.00475797
0.00658137
0.00765464
0.00814225
40
6.30631
33.3333
33.3333
33.3333
28.5714
9.30233
13.0435
2
7
2
2
2
2
4
3
4.74786
4.69049
4.59814
4.56034
0.0086702
0.00918223
0.0100705
0.0104585
25
12.5
6.94444
8.51064
2
3
5
4
Table S2. continued
cyclin-dependent protein kinase inhibitor activity
4.50856
0.0110143
22.2222
2
soluble fraction
4.48521
0.0112745
3.73563
13
activation of pro-apoptotic gene products
4.36218
0.0127506
11.1111
3
positive regulation of interferon-beta production
4.29742
0.0136036
20
2
phosphatidylinositol binding
4.26213
0.0140923
10.7143
3
complement activation, classical pathway
4.26213
0.0140923
10.7143
3
signal transduction
4.18404
0.0152369
2.83533
26
response to unfolded protein
4.16619
0.0155112
10.3448
3
interspecies interaction between organisms
4.16437
0.0155395
4.03226
10
regulatory region DNA binding
4.10873
0.0164287
18.1818
2
immunoglobulin mediated immune response
4.10873
0.0164287
18.1818
2
cell surface receptor linked signaling pathway
3.94168
0.0194156
4.69799
7
cellular response to ionizing radiation
positive regulation vascular endothelial growth
factor production
3.93837
0.01948
16.6667
2
3.93837
0.01948
16.6667
2
protein targeting to membrane
3.93837
0.01948
16.6667
2
acute-phase response
3.81825
0.0219662
9.09091
3
extracellular region
3.81514
0.0220346
2.65018
30
gastrulation
3.78326
0.0227485
15.3846
2
activation of caspase activity
purinergic nucleotide receptor activity, G-protein
coupled
3.68242
0.0251621
6.55738
4
3.64103
0.0262252
14.2857
2
purine nucleotide biosynthetic process
3.50984
0.0299017
13.3333
2
release of cytochrome c from mitochondria
3.3882
0.0337695
12.5
2
negative regulation of phosphorylation
3.3882
0.0337695
12.5
2
cysteine-type peptidase activity
3.31663
0.0362749
7.5
3
regulation of immune response
regulation of cyclin-dependent protein kinase
activity
3.28865
0.0373043
5.7971
4
3.19276
0.0410584
7.14286
3
cellular response to mechanical stimulus
3.19276
0.0410584
7.14286
3
cysteine-type endopeptidase activity
3.19276
0.0410584
7.14286
3
antigen binding
3.16898
0.0420466
11.1111
2
aging
3.14129
0.043227
4.7619
5
cell communication
3.13353
0.0435637
6.97674
3
chromosome
3.08169
0.0458817
4.22535
6
response to organic substance
3.07599
0.0461438
6.81818
3
signal transducer activity
3.07333
0.0462666
2.94118
15
induction of apoptosis by extracellular signals
3.0718
0.0463376
5.40541
4
response to bacterium
3.06959
0.0464404
10.5263
2