Download The Citric Acid Cycle (Citrate Cycle, Tricarboxylic Acid (TCA) Cycle

The Citric Acid Cycle (Citrate Cycle, Tricarboxylic Acid (TCA) Cycle, Krebs Cycle)
Acetyl-CoA + 3NAD+ + FAD + GDP + Pi + 2H2O
2CO2 + CoA-SH + 3NADH + FADH2 + GTP + 2H+
Pyruvate
Fatty acids
(f rom glycolysis or aa breakdown)
(via " -oxidation")
O
H3C*
C*
S-CoA
Acetyl-CoA
*COO-
CoA-SH
*CH2
*COOHO
O *C
NADH + H+
X
NAD+
X
CH2
OH
*
X
X
H
CH2
H+
*COO-
COO-
COO-
Oxaloacetate
*COO-
H2O
C
H
malate
dehydrogenase
C
cis-Aconitate
COO-
H2O
aconitase
fumarase
H
*
C
X
X
COO-
COO-
CH2
H2O
OOC
*CH2
Citrate
citrate
synthase
Malate
-
H2O
COO-
C
*COO*CH2
*COOH
C
HO
H
COOH
COO-
Fumarate
Isocitrate
succinate
dehydrogenase
FADH2
isocitrate
dehydrogenase
NAD+
NADH
+ H+
FAD
* COO*COO-
* CH2
X
CH2
X
COO-
succinyl-CoA
synthetase
Succinate
*CH2
-ketoglutarate
dehydrogenase
complex
O
* COO* CH2
CoA-SH
+ GTP GDP
+ Pi
*COOCO2 CoA-SH
CH2
C
O
S-CoA
Succinyl-CoA
NADH
NAD+
C
COO-
Oxalosuccinate
*CH2
CH2
O
COO-
H
CO2
H+
C
COO-
-Ketoglutarate
[ ] cis-aconitate and oxalosuccinate are reaction intermediates
*,X the carbons f rom acetyl-CoA occupy def ined positions in the cycle intermediates in the f irst round (they aren't immediately released as CO2)