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The Citric Acid Cycle (Citrate Cycle, Tricarboxylic Acid (TCA) Cycle, Krebs Cycle) Acetyl-CoA + 3NAD+ + FAD + GDP + Pi + 2H2O 2CO2 + CoA-SH + 3NADH + FADH2 + GTP + 2H+ Pyruvate Fatty acids (f rom glycolysis or aa breakdown) (via " -oxidation") O H3C* C* S-CoA Acetyl-CoA *COO- CoA-SH *CH2 *COOHO O *C NADH + H+ X NAD+ X CH2 OH * X X H CH2 H+ *COO- COO- COO- Oxaloacetate *COO- H2O C H malate dehydrogenase C cis-Aconitate COO- H2O aconitase fumarase H * C X X COO- COO- CH2 H2O OOC *CH2 Citrate citrate synthase Malate - H2O COO- C *COO*CH2 *COOH C HO H COOH COO- Fumarate Isocitrate succinate dehydrogenase FADH2 isocitrate dehydrogenase NAD+ NADH + H+ FAD * COO*COO- * CH2 X CH2 X COO- succinyl-CoA synthetase Succinate *CH2 -ketoglutarate dehydrogenase complex O * COO* CH2 CoA-SH + GTP GDP + Pi *COOCO2 CoA-SH CH2 C O S-CoA Succinyl-CoA NADH NAD+ C COO- Oxalosuccinate *CH2 CH2 O COO- H CO2 H+ C COO- -Ketoglutarate [ ] cis-aconitate and oxalosuccinate are reaction intermediates *,X the carbons f rom acetyl-CoA occupy def ined positions in the cycle intermediates in the f irst round (they aren't immediately released as CO2)