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Primary FRCA SOE November 2016 Question topics for Monday 7th November 2016 Pharmacology Physiology 1 PHA - 101 - factors contributing to the uptake of inhalational agents? PHA - 228 - concepts of volume of distribution, clearance and half-life PHA - 348 - how can the effects of antibiotics on bacterial replication be be classified PHY-037 - ventilation/perfusion relationships | describe the distribution of an inspired breath within the lungs when upright PHY -168 - nausea and vomiting | what is the difference between vomiting and regurgitation PHY -051 - buffers | what is a buffer? 2 PHA - 152 - this graph shows the change in the fa/fi ratio over time following the start of inhalation anaesthesia administered in oxygen PHA - 218 - what effects does hepatic disease have on the ability to handle drugs PHA - 317 -by which mechanisms can drugs inhibit the activity of platelets? PHY -155- cellular neurophysiology. Describe the structure of a neuronal cellmembrane PHY -352- lactate physiology | how and where is lactate produced? PHY -066- baroreceptors | how does the cardiovascular system respond to a change in systemic blood pressure? 3 PHA - 141a - how do non-depolarising neuromuscular blocking agents work? PHA - 217 - what is an isomer? (ans- different compounds with identical atomic content). PHA - 330 - by what mechanisms can drugs influence gastric secretion? PHY -001 - arterial pressure wave | give the diagram of arterial pressure waveforms for 2 cardiac cycles PHY -271 - haemoglobin | describe the structure of haemoglobin. PHY -081 - body fluid control | describe what happens when one litre of normal saline is rapidly infused to a normovolaemic adult Clinical Physics 2 Clin 019 - A 68yr old insulin dependent diabetic is listed for an urgent left below knee amputation. His temperature is 38.5°C, he is confused. He is catheterised and his urine output over the past 24 hours is 500ml. The most recent blood glucose was 26 mmol/L. diabetic control? anaesthetic options for this patient?” This patient is transferred to the recovery area, where he has a SUDDEN CONVULSION PCM-034N Capnography. How does capnography work? Aim: infra-red spectroscopy and clinical use of capnography PCM -015N physics of gas laws. How do you work out how long an oxygen cylinder will last? Aim: display knowledge of gas laws and their practical application, including laws and behaviour below and around critical temperature PCM -039NBlood warming and heat transfer | what methods are available for warming blood prior to transfusion?(aim: physical principles of different types of blood warmers and heat transfer) 1 Clin 011 - Anaesthetise a 32 year old female for a total colectomy. She has long-standing ulcerative colitis and has recent episodes of abdominal pain, diarrhoea and pyrexia and is extremely anxious. Her current medications include 7.5mg prednisolone daily, sulphasalazine and azathioprine. What are the main anaesthetic issues with this patient? The patient has an epidural for post-op pain relief, (infusion of bupivacaine 0.1% and fentanyl 2mcg/ml). Six hours post-op. the ward sister bleeps you to review the patient because “THE EPIDURAL IS NOT WORKING”. What do you do? In general, what are the potential causes of oliguria following major abdominal surgery?" PCM -033N measuring fio2 and po2. | how may the concentration of oxygen in a gas mixture be measured? (aim:how specific analysers work - paramagnetic analysers in detail PCM -045N LMA | what types of supraglottic airway (lma) do you know? (aim: advantages and disadvantages of the various types of lma description of other airway devices) PCM -056N force/energy/work | what do you understand by "force" and what are its units? (aim: to understand the concepts and Use of force, energy and power) 3 Clin 020 -. You are asked to anaesthetise a 23 year old female for a tonsillectomy. She has mild asthma requiring inhaled salbutamol when her “chest feels a bit tight. Outline your preoperative assessment & anaesthetic management? During laryngoscopy an upper incisor is damaged. How will you manage the situation? Laryngoscopy could have been avoided by using a laryngeal mask airway. What are the indications for the use of an LMA? ES-015N resuscitation bags and valve | “when would you use this Piece of equipment?” (show photograph of self inflating bag) Aim: understanding components, advantages and disadvantages of self-inflating bags and non-rebreathing valves PCM -048N measurement of functional residual capacity. Which lung volumes cannot be directly measured with a spirometer? (aim: measurement of frc PCM -063 physics of light | how is light transmitted down a fibrescope fibrescope? Aim: physics of light and its application to anaesthesia Paper