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CURRICULUM VITAE
NAME:
Jonathan F. Head
ADDRESS: 6144 Hagerstown Drive, Baton Rouge, Louisiana 70817
PHONE:
Home (225) 753-4939, Business (225) 755-3070
EDUCATION
Syracuse University; B.S., Zoology, 1971
Brooklyn College, CUNY; M.A., Biology, 1977
Fordham University; Ph.D., Biology, 1985
EMPLOYMENT
1988-Present
2015-
Chief Executive Officer/Chief Scientific
Pharmaceuticals, Inc., Baton Rouge, Louisiana.
Officer,
OncBioMune
2005-2015
President, Chief Scientific Officer; OncBioMune, LLC, Baton Rouge,
Louisiana.
2005-
Associate Member, Graduate Faculty, Louisiana State University, Baton
Rouge, Louisiana.
2005-
Adjunct Associate Professor; Department of Pathobiological Sciences,
Louisiana State University School of Veterinary Medicine, Baton Rouge,
Louisiana.
1999-2004
Director of Research and Development; Innovative Drug Technologies,
Oklahoma City, Oklahoma.
1998-2000
Adjunct Professor; Biodynamics Institute, Lousiana State University, Baton
Rouge, Louisiana.
1995-2001
Director of Research and Development; Medical Thermal Diagnostics,
Baton Rouge, Louisiana.
1992-
Adjunct Professor; Departments of Biological and Physical Sciences, Delta
State University, Cleveland, Mississippi.
1989-
Adjunct Associate Professor; Department of Biochemistry and Molecular
Biology, Tulane University School of Medicine, New Orleans, Louisiana.
1988-
Director of Research/Board Member; Sallie Astor Burdine Breast
Foundation, Baton Rouge, Louisiana.
1988-2015
President, Director of Research; Mastology Research Institute of The ElliottElliott-Head Breast Cancer Research and Treatment Center, Baton Rouge,
Louisiana.
1986-1988
Director/Department Head; Tumor Cell Biology, Center for Clinical
Sciences, International Clinical Laboratories/SmithKline Bio-Science
Laboratories, Nashville, Tennessee.
1978-1987
Mt. Sinai School of Medicine, New York, New York.
1986-1987
Research Assistant Professor; Department of Pediatrics, Mt. Sinai School of
Medicine, New York, New York.
1984-1986
Research Associate; Department of Pediatrics, Mt. Sinai School of Medicine,
New York, New York.
1981-1984
Graduate Student; Department of Biological Sciences, Fordham University,
Bronx, New York.
1978-1984
Research Assistant; Department of Pediatrics, Mt. Sinai School of Medicine,
New York, New York.
1978
Research Assistant; Department of Immunology, Cornell University Medical
College, New York, New York.
1974-1978
Biologist, Senior Biologist, Research Assistant; Division of Cell Biology,
Naylor Dana Institute for Disease Prevention, American Health Foundation,
Valhalla, New York.
1971-1974
Graduate Student, Adjunct Lecturer; Brooklyn College, CUNY, Brooklyn,
New York.
1972, 1973
Summer Research Assistant; Environmental Science Section, Boyce
Thompson Institute, Yonkers, New York.
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BIBLIOGRAPHY
Journal Publications
1. Chan, P.C., Tsuang, J., Head, J., Cohen, L.A., and Weisburger, J.H.: Effects of Estradiol and
Prolactin on Growth of Rat Mammary Adenocarcinoma Cells in Monolayer Cultures. Proc.
Soc. Exp. Biol. and Med. 151:362-365, 1976.
2. Chan, P.C., Head, J.F., Cohen, L.A., and Wynder,E.L.: The Influence of Dietary Fat on the
Induction of Rat Mammary Tumors by N-nitrosomethylurea: Associated Hormone Changes
and Differences Between Sprague-Dawley and F344 Rats. J. Natl. Cancer Inst. 59:1279-1283,
1977.
3. Greengard, O., Head, J.F., and Goldberg, S.L.: Uridine Kinase, Adenylate Kinase, and Guanase
in Human Lung Tumors. Cancer Research 40:2295-2299, 1980.
4. Greengard, O., Head, J.F., Goldberg, S.L., and Kirschner, P.A.: Enzyme Pathology and the
Histologic Categorization of Human Lung Tumors: The Continuum of Quantitative
Biochemical Indices of Neoplasticity. Cancer 49:460-467, 1982.
5. Greengard, O., Head, J.F., Koss, B., and Manton, M.: The Responses of Bone Marrow γGlutamyl Transpeptidase and Alkaline Phosphatase In Vitro to Tumor-elaborated
Granulocytopoietic Factors. Cancer Research 44:472-477, 1984.
6. Balinsky, D., Greengard, O., Cayanis, E., and Head, J.F.: Enzyme Activities and Isozyme
Patterns in Human Lung Tumors. Cancer Research 44:1058-1062, 1984.
7. Greengard, O., Head, J.F., Goldberg, S.L., and Kirschner, P.A.: Biochemical Measure of the
Volume Doubling Time (DT) of Human Pulmonary Neoplasms. Cancer 55:1530-1535, 1985.
8. Head, J.F.: A Biochemical Study of Tumor Growth and its Effect on Uninvolved Tissues of the
Host. Diss. Fordham Univ., 1986.
9. Greengard, O., Head, J.F., Goldberg, S.L., and Kirschner, P.A.: Pulmonary Carcinoid Tumors:
Enzyme Discriminants, Growth Rate and Early Age of Inception. Cancer Research 46:26002605, 1986.
10. Greengard, O., Head, J.F., Chahinian, P.A., and Goldberg, S.L.: Enzyme Pathology of Human
Mesotheliomas. J. Natl. Cancer Inst. 78:617-622, 1987.
11. Bhargava, G., Head, J.F., Bailey, S.C., and Greengard, O.: Characterization of a Mammary
Carcinoma Elaborated Factor Stimulating γ-Glutamyltranspeptidase Expression in Bone
Marrow Cells. Cancer Research 47:6262-6266, 1987.
12. Foster, L.B., and Head, J.F.: Adhesive Tumor Cell Culture System. J. Clin. Oncol. 6:178-179,
1988.
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13. Head, J.F., Bailey, S.C., Bhargava, G., and Greengard, O.: Enhancement of
γGlutamyltranspeptidase (GGT) Expression in Bone Marrow Cells by Colony Stimulating
Factors (CSFs). Enzyme 40:204-211, 1988.
14. Bailey, S.C., Head, J.F., and Greengard, O.: Neutrophil Maturation and Hypersegmentation
Promoted in Normal Bone Marrow by a Carcinoma-Elaborated Protein Factor. Am. J.
Hemotol. 31:159-165, 1989.
15. Head, J.F., Chahinian, A.P., and Greengard, O.: Enzymic Composition and Growth Rate of
Human Pleural Mesothelioma Transplants in Nude Mice. Cancer Biochem. Biophys. 12:127136, 1991.
16. Wang, F., Ledford, L.B., Head, J.F., Elliott, R.L.: Unique Method of Tissue Culture Preparation
for Electron Microscopy. Proc. 50th Annual Meeting of the Electron Microscopy Society of
America 50:728-729, 1992.
17. Elliott, R.L., Haynes, A.E., Bolin, J.A., Boagni, E.M., and Head, J.F.: Stereotaxic Needle
Localization and Biopsy of Occult Breast Lesions (First Year's Experience). Amer. Surg.
58:126-131, 1992.
18. Greengard, O., and Head, J.F.: Common Characteristics of Normal and Cancerous Growth In
Vivo. Adv. Enzyme Regulation 32:211-224, 1992.
19. Elliott, R.L., and Head, J.F.: Termografia Mamaria (Tecnica Clinica Valiosa o Despreciable).
Focus 3:41-42, 1992.
20. Wang, F., Head, J.F., and Elliott, R.L.: Deferoxamine Induced Ultrastructural Lesions of
Nucleoli in MCF-7 Carcinoma Cell Line. Proc. 51st Annual Meeting of the Microscopy
Society of America 51:198-199, 1993.
21. Head, J.F., Elliott, R.L., and McCoy, J.L.: Evaluation of Lymphocyte Immunity in Breast
Cancer Patients. Breast Cancer Res. Treat. 26:77-88, 1993.
22. Head, J.F., Wang, F., Elliott, R.L., and McCoy, J.L.: Assessment of Immunological
Competence and Host Reactivity Against Tumor Antigens in Breast Cancer Patients:
Prognostic Value and Rationale of Immunotherapy Development. Ann. New York Acad. Sci.
690:340-342, 1993.
23. Wang, F., Ledford, L.B., Head, J.F., and Elliott, R.L.: A Novel Cell Culture Technique for
Electron Microscopy. Microscopy Research and Technique 26:517-522, 1993.
24. Head, J.F., Wang, F., and Elliott, R.L.: Breast Thermography Is a Noninvasive Prognostic
Procedure That Predicts Tumor Growth Rate in Breast Cancer Patients. Ann. New York Acad.
Sci. 698:153-158, 1993.
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25. Elliott, R.L., Elliott, M.C., Wang, F., and Head, J.F.: Breast Carcinoma and the Role of Iron
Metabolism: A Cytochemical, Tissue Culture, and Ultrastructural Study. Ann. New York
Acad. Sci. 698:159-166, 1993.
26. Wang, F., Head, J.F., and Elliott, R.L.: Characterization of Morphological and Cytotoxic
Changes of Peripheral Blood Lymphocytes Induced by Interleukine-2. Proc. 52nd Annual
Meeting of the Microscopy Society of America 52:288-289, 1994.
27. Elliott, R.L., Wang, F., Elliott, M.C., and Head, J.F.: An Immunocytochemical, Cytosol, and
Ultrastructural Study of Tissue Ferritin in Breast Cancer. Proc. 52nd Annual Meeting of the
Microscopy Society of America 52:298-299, 1994.
28. Elliott, R.L., Head, J.F., and McCoy, J.L.: Comparison of Estrogen and Progesterone Receptor
Status to Lymphocyte Immunity Against Tumor Antigens in Breast Cancer Patients. Breast
Cancer Res. Treat. 30:299-304, 1994.
29. Elliott, R.L., Head, J.F., and McCoy, J.L.: Relationship of Serum and Tumor Levels of Iron and
Iron-binding Proteins to Lymphocyte Immunity Against Tumor Antigen in Breast Cancer
Patients. Breast Cancer Res. Treat. 30:305-309, 1994.
30. Elliott, R.L., Ledford, L.B., Head, J.F., and Wang, F.: A New Method of Preparing Cultured
Cells for EM. Microscopy and Analysis USA 13:15-16, 1995.
31. Head, J.F.: Will Molecular Biology Provide Oncologists with Information Useful for Risk
Assessment, Prognosis, or Therapeutic Decisions in Cancer Patients? Cancer Invest. 14:631632, 1996.
32. Head, J.F., and Elliott, R.L.: Letter to the Editor: Comment on 'When can Stereotactic Core
Biopsy Replace Excisional Biopsy?' Breast Cancer Res. Treat. 39:349, 1996.
33. Head, J.F., Lipari, C.A., Wang, F., Davidson, J.E., and Elliott, R.L.: Application of Second
Generation Infrared Imaging and Computerized Image Analysis to Breast Cancer Risk
Assessment. Proc. IEEE Eng. Med. Biol. 18:1019-1021, 1996.
34. Snyder, W., Wang, C., Wang, F., Elliott, R., and Head, J.: Improving the Resolution of Infrared
Images of the Breast. Proc. IEEE Eng. Med. Biol. 18:1058-1059, 1996.
35. Head, J.F., Haynes, A.E., Elliott, M.C., and Elliott, R.L.: Stereotaxic Localization and Core
Needle Biopsy of Nonpalpable Breast Lesions: Two Year Follow-up of a Prospective Study.
Amer. Surg. 62:1018-1023, 1996.
36. Head, J.F., and Elliott, R.L.: Correspondence on Thermography: Its Relation to Pathological
Characteristics, Vascularity, Proliferation Rate, and Survival of Patients with Invasive Ductal
Carcinoma of the Breast. Cancer 79:186-188, 1997.
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37. Head, J.F., Lipari, C.A., Wang, F., and Elliott, R.L.: Cancer Risk Assessment With a Second
Generation Infrared Imaging System. S.P.I.E. 3061:300-307, 1997.
38. Head, J.F., Wang, F., and Elliott, R.L.: Antineoplastic Drugs That Interfere With Iron
Metabolism in Cancer Cells. Advan. Enzyme Regul. 37:147-169, 1997.
39. Head, J., Lipari, C., Wang, F., and Elliott, R.: Image Analysis of Digitized Infrared Images of
the Breasts from a First Generation Infrared Images of the Breasts from a First Generation
Infrared Imaging System. Proc. IEEE Eng. Med. Biol. 19:681-684, 1997.
40. Luther, D., Davidson, J., Cromer, R., and Head, J.: A Head Mounted Infrared Imager for
Treating the Wounded on the Battlefield. Proc. IEEE Eng. Med. Biol. 19:722-724, 1997.
41. Lipari, C., and Head, J.: Advanced Infrared Image Processing for Breast Cancer Risk
Assessment. Proc. IEEE Eng. Med. Biol. 19:673-676, 1997.
42. Head, J.F., and Elliott, R.L.: Determination of Tumor Ferritin Concentration in Breast Cancer.
Meth. in Molecular Medicine 14:115-125, 1998.
43. Head, J.F., Lipari, C.A., and Elliott, R.L.: Computerized Image Analysis of Digitized Infrared
Images of the Breasts from a Scanning Infrared Imaging System. S.P.I.E. 3436:290-294, 1998.
44. Wang, F., Elliott, R.L., and Head, J.F.: Inhibitory Effect of Deferoxamine Mesylate and Low
Iron Diet on the 13762NF Rat Mammary Adenocarcinoma. Anticancer Res. 19:445-450,
1999.
45. Hargroder, A.G., Davidson, J.E., Luther, D.G., and Head, J.F.: Infrared Imaging of Burn
Wounds to Determine Burn Depth. S.P.I.E. 3698:103-108, 1999.
46. Head, J.F., Lipari, C.A., and Elliott, R.L.: Comparison of Mammography and Breast Infrared
Imaging: Sensitivity, Specificity, False Negatives, False Positives, Positive Predictive Value
and Negative Predictive Value. Proc. IEEE Eng. Med. Biol. 21:CDROM, 1999.
47. Head, J.F., Wang, F., Lipari, C.A., and Elliott, R.L.: The Important Role of Infrared Imaging in
Breast Cancer: New Technology Improves Applications in Risk Assessment, Detection,
Diagnosis and Prognosis. IEEE Eng. Med. Biol. 19:52-57, 2000.
48. Snyder, W.E., Qi, H., Elliott, R.L., Head, J.F., and Wang, C.X.: Increasing the Effective
Resolution of Thermal Images: An Algorithm Based on Mean-Field Annealing that Also
Removes Noise and Preserves Image Edges. IEEE Eng. Med. Biol. 19:63-70, 2000.
49. Wang, F., Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Doxorubicin-galliumtransferrin Conjugate Overcomes Multidrug Resistance: Evidence for Drug Accumulation In
the Nucleus of Drug Resistant MCF-7/ADR Cells. Anticancer Res. 20:799-808, 2000.
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50. Qi, H., Snyder, W.E., Head, J.F., and Elliott, R.L.: Detecting Breast Cancer from Infrared
Images by Asymmetry Analysis. Proc. IEEE Eng. Med. Biol. 22:CDROM, 2000.
51. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Reduction in Serum IL-6 After
Vaccination of Breast Cancer Patients with Tumor-associated Antigens is Related to Estrogen
Receptor Status. Cytokine 12:458-465, 2000.
52. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Vaccination with a Mixed Vaccine of
Autogenous and Allogeneic Breast Cancer Cells and Tumor Associated Antigens CA15-3,
CEA and CA125 - Results in Immune and Clinical Responses in Breast Cancer Patients.
Cancer Biother. Radiopharm. 15:495-505, 2000.
53. Yang, D.C., Wang, F., Elliott, R.L., and Head, J.F.: Expression of Transferrin Receptor and
Ferritin H-chain mRNA are Associated with Clinical and Histopathological Prognostic
Indicators in Breast Cancer. Anticancer Res. 21:541-549, 2001.
54. Yang, D.C., Jiang, X.P., Elliott, R.L., and Head, J.F.: Inhibition of Growth of Human Breast
Carcinoma Cells by an Antisense Oligonucleotide Targeted to the Transferrin Receptor Gene.
Anticancer Res. 21:1777-1787, 2001.
55. Qi, H., and Head, J.F.: Asymmetry Analysis Using Automatic Segmentation and Classification
for Breast Cancer Detection in Thermograms.
Proc. IEEE Eng. Med. Biol.
23:1347(CDROM), 2001.
56. Head, J.F., Lipari, C.A., and Elliott, R.L.: Determination of Mean Temperatures of Normal
Whole Breast and Breast Quadrants by Infrared Imaging and Image Analysis. Proc. IEEE
Eng. Med. Biol. 23:666(CDROM), 2001.
57. Elliott, R.L., Rice, P.B., Suits, J.A., Ostrowe, A.J., and Head, J.F.: Radiofrequency Ablation of
a Stereotactically Localized Nonpalpable Breast Carcinoma: A Case Report. Am. Surg. 68:15, 2002.
58. Yang, D.C., Elliott, R.L., and Head, J.F.: Gene Targets of Antisense Therapies in Breast
Cancer. Expert Opin. Ther. Targets 6:375-385, 2002.
59. Yang, D.C., Jiang, X.P., Elliott, R.L., and Head, J.F.: Antisense Ferritin Oligonucleotides
Inhibit Growth and Induce Apoptosis in Human Breast Carcinoma Cells. Anticancer Res.
22:1513-1524, 2002.
60. Jiang, X.P., Wang, F., Yang, D.C., Elliott, R.L., and Head, J.F.: Induction of Apoptosis by Iron
Depletion in Human Breast Cancer MCF-7 Cell Line and the 13762NF Rat Mammary
Adenocarcinoma In Vivo. Anticancer Res. 22:2685-2692, 2002.
61. Head, J.F., and Elliott, R.L.: Infrared Imaging: Making Progress in Fulfilling Its Medical
Promise (Past, Present and Future Applications of Infrared Imaging in Medicine). IEEE Eng.
Med. Biol. 21:80-85, 2002.
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62. Elliott, R.L., and Head, J.F.: Letter to the Editor: Minimally Invasive Breast Surgery
(Evolution, Expansion, and What’s on the Horizon). Am. Surg. 69:631-633, 2003.
63. Head, J.F., Hoekstra, P., Keyserlingk, J., Elliott, R.L, and Diakides, N.A.: Comparison of Breast
Infrared Imaging Results by Three Independent Investigators. Proc. IEEE Eng. Med. Biol.
25:1125-1128 (CDROM), 2003.
64. Head, J.F., Hoekstra, P., Keyserlingk, J., and Elliott, R.L: Concordance of Scores for Breast
Infrared Images by Three Independent Investigators. S.P.I.E. 5074:896-902, 2003.
65. Elliott, R.L., and Head, J.F.: Host Immunity Ignored in Clinical Oncology: A Medical Opinion.
Cancer Biother. Radiopharm. 20:119-121, 2005.
66. Elliott, R.L., and Head, J.F.: Complete Resolution of Malignant Ascites in Stage IV Breast
Cancer by Peritoneal Drainage and Innovative Chemoimmunotherapy: A Case Report. Cancer
Biother. Radiopharm. 21:33-40, 2006.
67. Elliott, R.L., and Head, J.F.: Breast Cancer Tumor Markers:
(Commentary). Cancer Detect. Prev. 32:188-189, 2008.
Worthless or Beneficial?
68. Head, J.F., and Elliott, R.L.: Stereotactic Radiofrequency Ablation: A Minimally Invasive
Technique for Nonpalpable Breast Cancer in Postmenopausal Patients. Cancer Epidemiol.
33:300-305, 2009.
69. Jiang, X.P., Elliott, R.L., and Head, J.F.: Manipulation of Iron Transporter Genes Results in
the Suppression of Human and Mouse Mammary Adenocarcinomas. Anticancer Res. 30:
759-766, 2010.
70. Head, J.F.: Regarding the “Rising Incidence of Tumorectomies without Breast Radiation in
Patients Treated for Invasive Breast Cancer in Caribbean Nations”. Southern Med. J.
103:286, 2010.
71. Elliott, R.L., DeLand, M., Head, J.F., and Elliott, M.C.: Accelerated Partial Breast
Irradiation: Initial Experience with the Intrabeam System. Surgical Oncology 20:73-79,
2011.
72. Elliott, R.L., Jiang, X.P., Phillips, J.T., Barnett, B.G., and Head, J.F.: HLA-G Expression in
Breast Cancer: Role in Immunosuppression. Cancer Biother. Radiopharm. 26:153-157,
2011.
73. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Down-regulation of Interleukin-6 and
its Receptor Results in Growth Inhibition of MCF-7 Breast Cancer Cells. Anticancer Res.
31:2899-2906, 2011.
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74. Serrero, G., Hawkins, D.M., Yue, B., Ioffe, O., Bejarano, P., Phillips, J., Head, J.F., Elliott,
R.L., Tkaczuk, K.R., Godwin, A.K., Weaver, J., and Kim, W.E.: Progranulin (GP88) Tumor
Tissue Expression is Associated with Increased Risk of Recurrence in Breast Cancer Patients
Diagnosed with Estrogen Receptor Positive Invasive Ductal Carcinoma. Breast Cancer
Research 14:R26, 1-12, 2012.
75. Elliott, R.L., and Head, J.F.: Cancer: Tumor Iron Metabolism, Mitochondrial Dysfunction and
Tumor Immunosuppression: “A Tight Partnership – Was Warburg Correct?” Journal of
Cancer Therapy 3:278-311, 2012.
76. Elliott, R.L., Jiang, X.P., and Head, J.F.: Mitochondria Organelle Transplantation:
Introduction of Normal Epithelial Mitochondria Into Human Cancer Cells Inhibits
Proliferation And Increases Drug Sensitivity. Breast Cancer Res. Treat. 136:347-354,
2012.
77. Elliott, R.L., and Head, J.F.: Adjuvant Breast Cancer Vaccine Improves Disease Specific
Survival of Breast Cancer Patients with Depressed Lymphocyte Immunity. Surgical
Oncology 22:172-177, 2013.
78. Elliott, R.L., Jiang, X.P., and Head J.F.: Want to Cure Cancer? Then Revisit the Past;
“Warburg Was Correct,” Cancer Is a Metabolic Disease. Journal of Cancer Therapy
5:297-305, 2014.
79. Elliott, R.L., Jiang, X.P., and Head, J.F.: Mitochondria Organelle Transplantation: The
Mitochondrion, “An Intracellular Organelle for Cell-Based Therapy” Opinion Commentary.
International Journal of Applied Science and Technology 4:158-162, 2014.
80. Jiang, X.P., Elliott, R.L., and Head, J.F.: Exogenous Normal Mammary Epithelial
Mitochondria Suppress Glycolytic Metabolism and Glucose Uptake of Human Breast Cancer
Cells. Breast Cancer Res. Treat. 153:519-529, 2015.
81. Elliott, R.L., Jiang, X.P., and Head, J.F.: Mitochondria Organelle Transplantation: “A
Potential Cellular Biotherapy for Caner”. J. Surgery S(2):9, 2015.
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Abstracts
1. Chan, P.C., Head, J.F., and Tsuang, J.: Hormonal Influence in Growth and cAMP Levels in a
Rat Mammary Adenocarcinoma Cell Line. In Vitro 13:190, 1977.
2. Chan, P.C., Head, J.F., Cohen, L.A., and Wynder, E.L.: Effect of High Fat Diet on Serum
Prolactin Levels and Mammary Cancer Development in Ovariectomized Rats. Proc. Amer.
Assoc. Cancer Res. 18:189, 1977.
3. Chan, P.C., Head, J.F., and Rochefort, H.: Growth Response of Two Rat Mammary Tumor Cell
Lines to Hormones. Meeting on Mammary Cancer in Experimental Animals and Man
11:110, 1978.
4. Head, J.F.: Changes in Enzyme Concentration Relating to Increases in Doubling Time
Characteristic of Gompertzian Growth in Transplantable Rat Tumors. Proc. Amer. Assoc.
Cancer Res. 23:23, 1982.
5. Head, J.F.: A Biochemical Study of Tumor Growth and its Effect on Uninvolved Tissues of the
Host. Diss. Abstr. Int. (Sci.) 46:2527, 1986.
6. Head, J.F., Bailey, S.C., Bhargava, G., and Greengard, O.: Gamma-Glutamyltranspeptidase
(GGT) and Alkaline Phosphatase (AP) Induction in Bone Marrow Cells by Colony Stimulating
Factors. Proc. Amer. Assoc. Cancer Res. 28:66, 1987.
7. Head, J.F., and Foster, L.B.: Demonstration of Antineoplastic Drug Cross-Resistance in Primary
Cultures of Human Tumor Cells Using the Adhesive Tumor Cell Culture System. Proc. Amer.
Assoc. Cancer Res. 29:85, 1988.
8. Head, J.F., Paolini, J.H., and Foster, L.B.: Growth of Normal Cells in the Adhesive Tumor Cell
Culture System. Proc. Amer. Assoc. Cancer Res. 30:112, 1989.
9. Head, J.F., Allen, P.J., Birch, B., Foster, L.B., and Oldham, R.K.: Evaluation of the Adhesive
Tumor Cell Culture System (ATCCS) Chemosensitivity (CS) Assay by the National
Biotherapy Study Group (NBSG). Proc. Amer. Soc. Clin. Oncol. 8:56, 1989.
10. Elliott, R.L., Page, M., and Head, J.F.: Further Evaluation of Platinum Transferrin (MPT-63)
and Daunorubicin Transferrin Conjugate as Potential Treatments for Breast Cancer (Possible
Synergistic Response). Antibody Immunoconj. and Radiopharm. 3:101, 1990.
11. Werneke, D.K., Head, J.F., and Elliott, R.L.: Relationship of Tissue Ferritin Concentration in
Breast Carcinomas to Estrogen and Progesterone Receptor Status. Proc. Amer. Assoc. Cancer
Res. 31:1015, 1990.
12. Head, J.F., and Elliott, R.L.: Inhibition of Human Breast Carcinoma MCF-7 Growth by Gallium
and Cisplatin Bound to Human Transferrin. Proc. Amer. Assoc. Cancer Res. 31:2440, 1990.
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13. Werneke, D.K., Head, J.F., Elliott, R.L., and Elliott, M.C.: A Comparison of Centocor CA-15.3,
CIS CA-15.3 and Hybritech CA-549, Serum Tumor Markers for Breast Carcinoma. Proc.
Amer. Soc. Clin. Oncol. 9:98, 1990.
14. Elliott, R.L., Head, J.F., and Werneke, D.K.: Thermography in Breast Cancer: Comparison with
Patient Survival, TNM Classification and Tissue Ferritin Concentration. Proc. Amer. Soc.
Clin. Oncol. 9:99, 1990.
15. Werneke, D.K., Head, J.F., Elliott, R.L., and Ledford, L.B.: Comparison of the Biochemical
Dextran-Coated Charcoal Assay (ER-DCC) with the Immunocytochemical Assay (ER-ICA) for
Estrogen Receptor in Breast Tumors. Amer. J. Clin. Path. 94:505, 1990.
16. Elliott, R.L., Elliott, M.C., and Head, J.F.: Preliminary Results on 11 Advanced Breast Cancer
Patients Treated with Cisplatin Complexed to Human Transferrin. Breast Cancer Res. Treat.
16:57, 1990.
17. McCoy, J.L., Herberman, R.B., Head, J., and Elliott, R.: Predicting Survival in Breast Cancer
Patients by Measuring Cellular Immunity Against Tumor Associated Antigens. Breast Cancer
Res. Treat. 16:69, 1990.
18. Head, J.F., and Elliott, R.L.: Cisplatin-transferrin Complex Acts Synergistically with
Doxorubicin to Inhibit the Growth of Cultured MCF-7 Cells. International Symposium on
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 6:63,
1991.
19. Elliott, R.L., Elliott, M.C., Ledford, L., Werneke, D.K., and Head, J.F.: Ultrastructural
Observations of Breast Carcinoma: Possible Prognostic Indicators. Proc. Amer. Soc. Clin.
Oncol. 10:131, 1991.
20. Elliott, R.L., Haynes, A.E., Bolin, J.A., Boagni, E.M., and Head, J.F.: Stereotaxic Needle
Localization and Biopsy of Occult Breast Lesions (First Year's Experience). Southeastern
Surg. Conference 59:16, 1991.
21. Werneke, D.K., Elliott, R.L., Head, J.F., and Ledford, L.B.: Comparison of
Immunocytochemical and Steroid-Binding Assays for Estrogen Receptors in Breast
Carcinomas. Proc. Amer. Assoc. Cancer Res. 32:1088, 1991.
22. Head, J.F., and Elliott, R.L.: Inhibition of MCF-7 and HeLa Cell Growth by Gallium- and
Indium-Transferrin Complexes. Proc. Amer. Assoc. Cancer Res. 32:2298, 1991.
23. Head, J.F., Shah, U., Elliott, M.S., and Elliott, R.L.: Breast Thermography and Cancer Patient
Survival. Thermology 3:277, 1991.
24. Head, J.F. and Elliott, R.L.: Inhibition of Cell Growth in Mammary Carcinoma Cell Lines by
Deferoxamine Mesylate. Breast Cancer Res. Treat. 19:209, 1991.
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25. Head, J.F., Bruce, T.L. and Elliott, R.L.: Inhibitory Effect of Deferoxamine Mesylate on the
Growth of HeLa and MCF-7 Carcinoma Cell Lines. Proc. Amer. Assoc. Cancer Res. 33:505,
1992.
26. Elliott, R.L., Elliott, M.C. and Head, J.F.: Iron Metabolism in Breast Cancer (A Cytochemical,
Tissue Culture, and Ultrastructural Study). Proc. Amer. Soc. Clin. Oncol. 11:62, 1992.
27. Head, J.F., Haynes, A.E. and Elliott, R.L.: One Year Follow-up of Patients With Abnormal
Mammograms That Had Stereotaxic Localization and Needle Biopsy of Nonpalpable Breast
Lesions With the Mammotest II. Proc. Amer. Soc. Clin. Oncol. 11:62, 1992.
28. Head, J.F., Wang, F., and Elliott, R.L.: Study of Iron Metabolism in Tumor Cells Suggests
Novel Experimental Approaches to Cancer Chemotherapy. International Assoc. Breast
Cancer Res., Biennial Meeting. A60, 1993.
29. Elliott, R.L., Elliott, M.C., Wang, F., and Head, J.F.: A Cytochemical, Tissue Culture and
Ultrastructural Study: The Role of Iron Metabolism in Breast Carcinoma. International
Assoc. Breast Cancer Res., Biennial Meeting. A61, 1993.
30. Head, J.F., Bruce, T.L., Haynes, A.E., Elliott, M.C., and Elliott, R.L.: Two Year Follow-up of a
Prospective Study of Patients with Abnormal Mammograms who had Stereotaxic Localization
and Needle Biopsy of Non-palpable Breast Lesions. Proc. Amer. Soc. Clin. Oncol. 12:56,
1993.
31. Elliott, R.L., Head, J.F., and McCoy, J.L.: Immunomodulation of Lymphocyte-mediated
Immunity in Breast Cancer Patients Following Adjuvant Chemotherapy. Proc. Amer. Soc.
Clin. Oncol. 12:294, 1993.
32. Elliott, R.L., Wang, F., Elliott, M.C., Ledford, L.B., and Head, J.F.: Ultrastructural Pathology of
Human Breast Carcinoma (Observation in 592 Patients). Proc. Amer. Assoc. Cancer Res.
34:91, 1993.
33. Head, J.F., Simmons, E.M., Ledford, L.B., and Elliott, R.L.: Immunocytochemical Analysis of
Estrogen and Progesterone Receptors in Paraffin Embedded Breast Cancer Tissue. Proc.
Amer. Assoc. Cancer Res. 34:191, 1993.
34. Head, J.F., Elliott, R.L., and McCoy, J.L.: Effect of Adjuvant Chemotherapy on Lymphocytemediated Immunity in Breast Cancer Patients. J. Immunother. 14:365, 1993.
35. Wang, F., Hailey, M., Elliott, R.L., and Head, J.F.: Inhibitory Effect of Deferoxamine Mesylate
on the Growth of Rat 13762NF Mammary Adenocarcinoma. Breast Cancer Res. Treat.
27:151, 1993.
12
36. Head, J.F., Nutt, D.R., Elliott, M.C., Wang, F., and Elliott, R.L.: Phase I/II Study of Sequentially
Administered Deferoxamine, Cisplatin-transferrin Complex and FAC (5-fluorouracil,
Doxorubicin, Cyclophosphamide) in Advanced Breast Cancer. Proc. Amer. Assoc. Cancer
Res. 35:227, 1994.
37. Elliott, R.L., Wang, F., and Head, J.F.: Ultrastructural Observations Confirm Malignant
Epithelium to be the Source of Tissue Ferritin in Breast Carcinoma. Proc. Amer. Assoc.
Cancer Res. 35:228, 1994.
38. Wang, F., Hailey, M., Ward, K., Elliott, R.L., and Head, J.F.: Growth Inhibition of Rat
13762NF Mammary Adenocarcinoma by Deferoxamine Mesylate. Proc. Amer. Assoc.
Cancer Res. 35:406, 1994.
39. Elliott, R.L., Elliott, M.C., Wang, F., and Head, J.F.: The Role of Iron Metabolism in Metastatic
Breast Carcinoma (Synergistic Action of Cisplatinum Transferrin Complex and Doxorubicin).
Proc. Amer. Soc. Clin. Oncol. 13:80, 1994.
40. Head, J.F., Wang, F., and Elliott, R.L.: Lymphocyte Blastogenesis Assay (LBA) Monitoring of
Breast Cancer Patients (PTs) Vaccinated with Autologous and Allogeneic Tumor-associated
Antigens. Proc. Amer. Soc. Clin. Oncol. 13:301, 1994.
41. Head, J.F., Nutt, D.R., Elliott, M.C., and Elliott, R.L.: Phase I-II Trial in Advanced Breast
Cancer Patients of Sequential Combination Chemotherapy with Deferoxamine, CisplatinTransferrin Complex and FAC (5-Fluorouracil, Doxorubicin, Cyclophosphamide). Annals of
Oncology 5:34, 1994.
42. Elliott, R.L., Elliott, M.C., Wang, F., and Head, J.F.: Innovative Chemotherapy in Breast Cancer
by Modulation of Transferrin Receptors: Transferrin as a Carrier of Cytotoxic Agents. Annals
of Oncology 5:193, 1994.
43. Head, J.F., Wang, F., and Elliott, RL.: Lymphocyte Blastogenesis Assay Monitoring of Changes
in the Immune Status of Breast Cancer Patients Vaccinated with Autologous and Allogeneic
Tumor Associated Antigens. Breast Cancer Res. Treat. 32:62, 1994.
44. Head, J.F., Wang, F., Hailey, M.W., and Elliott, R.L.: Vaccination of Breast Cancer Patients
with Autologous Tumor-Associate Antigens Results in Increased Lymphocyte Blastogenesis
Assay Ratios and Decreased Serum Concentrations of the Tumor Marker 15-3. Southeastern
Surg. Conference 63:9, 1995.
45. Head, J.F., Ledford, L.B., Brewer, M.M., and Elliott, R.L.: Comparison of Tissue Ferritin
Concentrations Determined by Immunocytochemical Analysis and Microparticle Enzyme
Immunoassay in Breast Cancer. Proc. Amer. Assoc. Cancer Res. 36:208, 1995.
46. Head, J.F., Wang, F., and Elliott, R.L.: Vaccination of Breast Cancer Patients with Autologous
Tumor-associated Antigens Results in Decreased Serum Concentrations of the Tumor Marker
CA 15-3. Journal Tumor Marker Oncol. 10:45, 1995.
13
47. Head, J.F., Brewer, M.M., Ledford, L.B., Wang, F., and Elliott, R.L.: Breast Tumor Ferritin
Concentrations Determined by Microparticle Enzyme Immunoassay, Immunocytochemical
Analysis and Electron Microscopy. Breast Cancer Res. Treat. 33:103, 1995.
48. Elliott, R.L., Nutt, D.R., Elliott, M.C., and Head, J.F.: Clinical Study of Sequential
Deferoxamine Cisplatin or Gallium Transferrin Complex, and Cytotoxic Chemotherapy in
Advanced Breast Cancer. International Congress on Anti-Cancer Chemotherapy 5:158,
1995.
49. Head, J.F., Wang, F., and Elliott, R.L.: Study of Iron Metabolism in Tumor Cells Suggests
Novel Experimental Approaches to Cancer Chemotherapy. International Congress on AntiCancer Chemotherapy 5:159, 1995.
50. Wang, F., Head, J.F., and Elliott, R.L.: The Up Regulation of Transferrin Receptors by
Deferoxamine Enhances the Growth Inhibitory Effect of Gallium-transferrin on MCF-7 Cells.
Proc. Amer. Assoc. Cancer Res. 36:355, 1996.
51. Head, J.F., Kleinbeck, S.M., Hailey, M.W., and Elliott, R.L.: Three Year Follow-up of a
Prospective Study of 219 Patients with Abnormal Mammograms who had Stereotaxic
Localization and Core Needle Biopsy of Nonpalpable Lesions. Proc. Amer. Soc. Clin. Oncol.
15:111, 1996.
52. Elliott, R.L., Wang, F., Lipari, C.A., and Head, J.F.: Application of Second Generation Infrared
Imaging to Breast Cancer Risk Assessment. Southeastern Surg. Conference 65:16, 1997.
53. Yang, D.C., Head, J.F., Wang, F. and Elliott, R.L.: Transferrin Receptor mRNA and Ferritin Hchain mRNA Expression are Associated with Prognostic Indicators for Breast Cancer. Proc.
Amer. Assoc. Cancer Res. 38:419-420, 1997.
54. Wang, F., Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Effects of Gallium and
Gallium-transferrin on DNA Synthesis, Ferritin Gene Expression and Cellular Ferritin
Synthesis in MCF-7 Cells. Proc. Amer. Assoc. Cancer Res. 38:601, 1997.
55. Head, J.F., Wang, F., Lipari, C.A., and Elliott, R.L.: Breast Cancer Risk Assessment with an
Advanced Infrared Imaging System. Proc. Amer. Soc. Clin. Oncol. 16:172, 1997.
56. Luther, D.G., Davidson, J.E., and Head, J.F.: Helmet Mounted Infrared Imaging Combat
Casualty System. Adv. Tech. Application Combat Casualty Care CDROM, 1997.
57. Wang, F., Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Doxorubicin-galliumtransferrin Conjugate Overcomes Multidrug Resistance:
Evidence for nuclear Drug
Accumulation in Resistant Cells MCF-7/ADR. Breast Cancer Res. Treat. 46:236, 1997.
58. Jiang, X.P., Wang, F., Head, J.F., Yang, D.C., and Elliott, R.L.: The Deprivation of Iron
Induces Apoptosis in MCF-7 Human Breast Cancer Cell Line and 13762NF Rat mammary
Adenocarcinoma Tumor. Breast Cancer Res. Treat. 46:468, 1997.
14
59. Yang, D.C., Head, J.F., Wang, F., Jiang, X.P., Ferris, J., and Elliott, R.L.: Growth Inhibition of
Multidrug-sensitive and Multidrug-resistant Human Breast Cancer Cell Lines by GalliumTransferrin. Proc. Amer. Assoc. Cancer Res. 39:1760, 1998.
60. Jiang, X.P., Head, J.F., Yang, D.C., and Elliott, R.L.: Vaccination of Breast Cancer Patients
With Autologous Tumor-associated Antigens Results in Reduction of Serum Interleukin-6.
Proc. Amer. Assoc. Cancer Res. 39:2841, 1998.
61. Yang, D.C., Head, J.F., Jiang, X.P., Wang, F., and Elliott, R.L.: Antisense Transferrin Receptor
Oligonucleotide Suppresses Gene Expression and Proliferation in Human Breast Cancer Cell
Lines. Proc. Amer. Assoc. Cancer Res. 39:2841, 1998.
62. Yang, D.C., Head, J.F., Jiang, X.P., and Elliott, R.L.: Expression of Cytokeratin 19 mRNA is
Associated with Differentiation of Human Breast Tumors. Proc. Amer. Soc. Clin. Oncol.
17:2198, 1998.
63. Jiang, X.P., Head, J.F., and Elliott, R.L.: Vaccination of Breast Cancer Patients with
Autologous Tumor-associated Antigens Results in Reduction of Serum Interleukin-6. Proc.
Soc. Surg. Oncol. 52:39, 1998.
64. Luther, D.G., Head, J.F., Davidson, J.E., Grenn, M., Hargroder, A.G., and Hubble, K.: A Head
Mounted Thermal Imaging System for the Medic. Adv. Tech. Application Combat Casualty
Care CDROM, 1998.
65. Yang, D.C., Head, J.F., Jiang, X.P., and Elliott, R.L.: Reversal of Multidrug Resistance in the
Human Breast Cancer MCF-7/ADR Cell Line by Gene-targeted Antisense Oligonucleotides.
Breast Cancer Res. Treat. 50:360, 1998.
66. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Serum IL-6 Concentration is Increased in
Postmenopausal and Estrogen Receptor Negative Breast Cancer Patients. Breast Cancer Res.
Treat. 50:480, 1998.
67. Jiang, X.P., Yang, D.C., Head, J.F., and Elliott, R.L.: All-trans-retinoic Acid Down-Regulates
Interleukin-6 Synthesis in Human Breast Cancer Cells. Proc. Amer. Assoc. Cancer Res.
40:417, 1999.
68. Yang, D.C., Head, J.F., Jiang, X.P., and Elliott, R.L.: Liposome Mediated Antisense Ferritin
Light Chain Transfection Inhibits Proliferation of Human Breast Cancer Cells. Proc. Amer.
Assoc. Cancer Res. 40:3160, 1999.
69. Yang, D.C., Jiang, X.P., Elliott, R.L., and Head, J.F.: Reversal of Doxorubicin Resistance by
Doxorubicin-Gallium-Transferrin Conjugate in Human Breast Cancer Cell Lines. Proc. Amer.
Assoc. Cancer Res. 40:4377, 1999.
15
70. Elliott, R.L., Suits, J.A., Yang, D.C., Jiang, X.P., and Head, J.F.: Increase in Serum Iron
Concentration After Chemotherapy for Breast Cancer. Proc. Amer. Soc. Clin. Oncol. 18:805,
1999.
71. Head, J.F., Jiang, X.P., Yang, D.C., and Elliott, R.L.: Serum Interleukin-6 (IL-6) Concentration
Correlates with Serum Tumor Marker CA15-3 Concentration in Breast Cancer Patients. Proc.
Amer. Soc. Clin. Oncol. 18:2438, 1999.
72. Elliott, R.L., and Head, J.F.: Medical Infrared Imaging in the Twenty-first Century.
Thermology International 9:111, 1999.
73. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Serum IL-6 Reduction After Vaccination
of Breast Cancer Patients with Tumor-associated Antigens Is Related to Estrogen Receptor
Status. J. Immunother. 22:459, 1999.
74. Yang, D.C., Elliott, R.L., Jiang, X.P., and Head, J.F.: Antisense-transferrin Receptor Gene
Inhibits Growth of Breast Tumor Cells. Breast Cancer Res. Treat. 57:180, 1999.
75. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Interleukin-6 Enhances Tumor Antigen
Expression in the MCF-7 Human Breast Cancer Cell Line and Breast Cancer Patients. Breast
Cancer Res. Treat. 57:374, 1999.
76. Jiang, X.P., Yang, D.C., Head, J.F., and Elliott, R.L.: Interleukin-6 is a Growth Factor for
Human Breast Cancer Cells. Breast Cancer Res. Treat. 57:477, 1999.
77. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Immune Responses in Breast Cancer
Patients Vaccinated with Autologous Tumor Cells, Allogeneic Tumor Cells and the tumor
Antigen CA 15-3. Cancer Biother. Radiopharm. 15:110, 2000.
78. Yang, D.C., Jiang, X.P., Elliott, R.L., and Head, J.F.: Synergistic Inhibition of Breast Tumor
MCF-7 Cell Growth by Combinations of Transferrin Receptor Antisense DNA, Deferoxamine
and Hydroxyurea. Proc. Amer. Assoc. Cancer Res. 41:4091, 2000.
79. Yang, D.C., Jiang, X.P., Elliott, R.L., and Head, J.F.: Antisense Transferrin Receptor
Oligonucleotide Induces Apoptosis in Human MCF-7 Breast Carcinoma Cells. Proc. Amer.
Assoc. Cancer Res. 41:4781, 2000.
80. Jiang, X.P., Head, J.F., Yang, D.C., and Elliott, R.L.: Immune Responses in Breast Cancer
Patients Vaccinated with Autologous and Allogeneic Tumor Cells. Eur. J. Sur. Oncol.
26:260, 2000.
81. Yang, D.C., Jiang, X.P., Head, J.F., and Elliott, R.L.: Clinical Significance of MDR1 and MRP
Gene Expression in Primary Breast Tumors. Proc. Amer. Soc. Clin. Oncol. 19:833, 2000.
16
82. Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Vaccination with a Mixture of
Autologous and Allogeneic Breast Cancer Cells and the Tumor Associated Antigens CA15-3,
CEA, and CA125: Results in Immune and Clinical Responses in Breast Cancer Patients. Proc.
Amer. Soc. Clin. Oncol. 19:1827, 2000.
83. Li, W., and Head, J.: Infrared Imaging in the Detection and Evaluation of Tumor Angiogenesis.
Proc. IEEE Eng. Med. Biol. 22:CDROM, 2000.
84. Elliott, R.L., Suits, J.A., and Head, J.F.:
Combination Chemotherapy and Active
Immunotherapy for Breast Cancer Patients with Advanced Disease. Southeastern Surg.
Conference 69:12, 2001.
85. Head, J.F., Bruce, T.L., Wang, F., and Elliott, R.L.: Gallium Loaded Transferrin as a Specific
Carrier of Paclitaxel into Breast Cancer Cells. Proc. Amer. Assoc. Cancer Res. 42:2019,
2001.
86. Yang, D.C., Jiang, X.P., Elliott, R.L., and Head, J.F.: Synergistic Inhibition of Breast
Carcinoma Cell Growth by Combinations of HER-2/neu Antisense DNA and
Chemotherapeutic Agents. Proc. Amer. Assoc. Cancer Res. 42:3915, 2001.
87. Jiang, X.P., Yang, D.C., Head, J.F., and Elliott, R.L.: Liposomal-Mediated Transfer of the
Human Interleukin 6 Gene into MCF-7 Breast Cancer Cells Results in Increased Synthesis of
Tumor Associated Antigens. Proc. Amer. Assoc. Cancer Res. 42:4403, 2001.
88. Head, J.F., and Elliott, R.L.: Vaccination of Prostate Cancer Patients with a Vaccine Containing
Prostate Specific Antigen (PSA) Results in Reduced Serum PSA. Proc. Amer. Soc. Clin.
Oncol. 20:1106, 2001.
89. Yang, D.C., Head, J.F., Hanks, C., Jiang, X., and Elliott, R.L.: Her-2/neu Messenger RNA
Expression in Human Breast Tumors Has Prognostic Significance. Proc. Amer. Soc. Clin.
Oncol. 20:2626, 2001.
90. Head, J.F., Lipari, C.A., and Elliott, R.L.: Determination of Mean Temperatures of Normal
Whole Breast and Breast Quadrants by Infrared Imaging and Image Analysis. Thermology
International 11:145, 2001.
91. Head, J.F., Jiang, X.P., and Elliott, R.L.: Vaccination of Prostate Cancer Patients with Prostate
Specific Antigen and Biological Adjuvants Reduces Serum PSA. J. Immunother. 24:26,
2001.
92. Head, J.F., Jiang, X.P., and Elliott, R.L.: Phase I/II Study of Vaccination with Prostate Specific
Antigen and Biological Adjuvants in Prostate Cancer Patients. Proc. AACR New Discoveries
in Prostate Cancer Biology and Treatment 1:B20, 2001.
17
93. Yang, D.C., McCreary, M.S., Jiang, X.P., Elliott, R.L., and Head, J.F.: Inhibition of Human
Breast Cancer Cell Growth by a Plasmid that Expresses Her-2/neu Antisense RNA. Proc.
Amer. Assoc. Cancer Res. 43:439, 2002.
94. Jiang, X.P., Head, J.F., and Elliott, R.L.: Targeting of Transferrin Receptor with a Transferrin
Receptor Antibody-doxorubicin-loaded Liposome Suppresses the Proliferation of MCF-7 Breast
Cancer Cells. Proc. Amer. Assoc. Cancer Res. 43:2065, 2002.
95. Jiang, X.P., Head, J.F., and Elliott, R.L.: Targeting of HER2 with Herceptin-doxorubicinloaded Liposomes Suppresses the Proliferation of MCF-7 Breast Cancer Cells. Proc. Amer.
Soc. Clin. Oncol. 21:1834, 2002.
96. Jiang, X., Elliott, R.L., and Head, J.F.: Downregulation of interleukin 6 expression results in
growth inhibition of MCF-7 breast cancer cells. Breast Cancer Res. Treat. 76:681, 2002.
97. Elliott, R.L., Head, J.F., Ostrowe, A.J., Rice, P.B., and Suits, J.A.: Radiofrequency Ablation of
Stereotactically Localized Nonpalpable Breast Carcinomas. Proc. Amer. Assoc. Cancer Res.
44:1516, 2003.
98. Jiang, X., Elliott, R.L., and Head, J.F.: Targeting of Cancer Antigen 15-3 (CA 15-3) with a CA
15-3 Antibody-doxorubicin-loaded Liposome Complex Increases Doxorubicin Cytotoxicity
Against the MCF-7 Human Breast Cancer Cells. Proc. Amer. Assoc. Cancer Res. 44:3663,
2003.
99. Jiang, X., Head, J.F., and Elliott, R.L.: Iron Protects MCF-7 Breast Cancer Cells from the
Cytotoxic Effect of Nitric Oxide. Proc. Amer. Assoc. Cancer Res. 44:5024, 2003.
100. Jiang, X., Hsu, K., Denicola, D., Head, J.F., and Elliott, R.L.: Iron Impairs Natural Killer Cell
Function. Proc. Amer. Assoc. Cancer Res. 45:674, 2004.
101. Jiang, X., Hsu, K., Meseyton, D., Denicola, D., Elliott, R.L.,and Head, J.F.: Doxorubicingallium-transferrin and Cisplatin-transferrin Conjugates Reverse Hypoxia-induced Drug
Resistance in Breast Cancer MCF-7 Cells. Proc. Amer. Assoc. Cancer Res. 45:2142, 2004.
102. Hsu, K., Head, J.F., Jiang, X., and Elliott, R.L.: Whole Cell Preparations of MCF-7 Breast
Carcinoma Cells are More Active Than Lysed Cell Preparations in Lymphocyte
Blastogenesis Assays (LBAs) of Breast Cancer Patients. Proc. Amer. Soc. Clin. Oncol.
22:2596, 2004.
103. Head, J.F., Hsu, K., Jiang, X., and Elliott, R.L.: Multiple Antigens in a Breast Cancer Vaccine
Result in a Higher Immune Response Rate in Breast Cancer Patients. Proc. Amer. Soc. Clin.
Oncol. 22:2607, 2004.
104. Elliott, R.L., and Head, J.F.: Autologous Vaccine Improves Host Immunity in Breast Cancer.
Proc. Am. Soc. Breast Surg. 5:34, 2004.
18
105. Head, J.F., Elliott, R.L., Keyserlingk, J.R., Gavin, R.J., and Diakides, N.A.: Development and
Early Results of a Breast Infrared Database (MedATR). Proc. Am. Acad. Thermology 31:16,
2004.
106. Elliott, R.L., and Head, J.F.: Improving Host Immunity in Breast Cancer with an Autologous
Vaccine. Cancer Immunotherapeutics (CHI) 1:5, 2004.
107. Head, J.F., and Elliott, R.L.: Phase I/II Clinical Trials of Breast and Prostate Cancer Vaccines
Consisting of Biological Adjuvants and Cellular and Protein Antigens. Breast and Prostate
Cancer “Similarities and Differences” for Pathologists and Clinicians 1:2, 2005.
108. Jiang, X.P., Hsu, K., Head, J.F., and Elliott, R.L.: Effects of Iron on the Cytotoxicity of Nitric
Oxide and the Associated Cytolysis by Natural Killer Cells of MCF-7 Human Breast Cancer
Cells. Proc. Amer. Assoc. Cancer Res. 46:2433, 2005.
109. Elliott, R.L.., and Head, J.F.: Improving Host Immunity in Breast Cancer with an Autologous
Vaccine. Proc. Am. Soc. Breast Disease 29:46, 2005.
110. Jiang, X.P., Elliott, R.L., and Head, J.F.: Hypoxia Enhances the Cytotoxicity of Cisplatin
Bound to Transferrin and Ferritin Heavy Chain Antisense to MCF-7 Cells. Advances in Breast
Cancer Research: Genetics, Biology, and Clinical Applications AACR:B8, 2005.
111. Head, J.F., Fort, K.A., Hsu, K., and Elliott, R.L.: Whole Cell Autologous/Allogeneic Vaccine
Induces an Immune Response to Specific Antigens in Breast Cancer Patients. Breast Cancer
Res. Treat. 94:4097, 2005.
112. Head, J.F., Fort, K.A., Hsu, K., and Elliott, R.L.: A Breast Cancer Vaccine Containing
Autologous and Allogeneic Whole Cells, Proteins and Biological Adjuvants Induces Immune
Responses in Breast Cancer Patients. Cancer Drugs Research and Development 3:234, 2006.
113. Jiang, X.P., Hsu, K., Head, J.F., and Elliott, R.L.: Iron Inhibits the Cytotoxicity of Nitric Oxide
and the Associated Cytolysis by Natural Killer Cells of MCF-7 Human Breast Cancer Cells.
Proc. Amer. Assoc. Cancer Res. 47:629, 2006.
114. Jiang, X.P., Boykin, E., Elliott, R.L., and Head, J.F.: An Antisense Oligonucleotide Targeting
the Heavy Chain of Ferritin Can Synergistically Increase the Antitumor Activity of rTNFa
Against the MCF-7 Human Breast Cancer Cell Line. Proc. Amer. Assoc. Cancer Res.
47:2101, 2006.
115. Barnett, B.G., Ruter, J., Cheng, P.J., Kryczek, I., Brumlik, M., Head, J., Elliott, R., Zou, W.,
and Curiel, T.J.: Phase II Trial of Ontak to Deplete Regulatory T Cells in Treatment of
Refractory Stage III/IV Ovarian Cancer. Proc. Amer. Assoc. Cancer Res. 47:4885, 2006.
116. Jiang, X., Israyelyan, A., Boykin, E., Lomax, L., Head, J.F., and Elliott, R.L.: Antisense
19
Oligonucleotide Targeted to Transferrin Receptor Gene Suppresses Tumor Growth and Lung
metastases in 4T1 Mammary Adenocarcinoma Mouse Model. Proc. Amer. Soc. Clin. Oncol.
24:10616, 2006.
117. Head, J.F., and Elliott, R.L.: Phase I/II Clinical Trial of a Prostate Cancer Vaccine Consisting of
Biological Adjuvants and Protein Antigens. Cancer Immunotherapeutics and Vaccines
(CHI) 3:17, 2006.
118. Elliott, R.L, Jiang, X., and Head, J.F.: Manipulation of Tumor Iron Metabolism Results in
Proper T-Cell Activation with Reversal of Immune Suppression in Cancer. Molecular Targets
in Cancer Therapy 4:27, 2007.
119. Elliott, R.L., DeLand, M., Head, J.F., Elliott, M.C., Duhon, J., Miller, S., and Ostrowe, A.J.:
Partial Breast Irradiation: Initial Experience with Intraoperative Radiotherapy Using the
IntraBeam System in Selected Breast Cancer Patients. Ann. Surg. Oncol. 14S:P21, 2007.
120. Jiang, X., Elliott, R.L., and Head, J.F.: The Expression of Iron Transport Genes in Human
Normal Mammary Epithelia and Breast Cancer Cells. Third Annual Scientific Meeting for
Cancer Research of the International Academy of Pathology. 3:42, 2007.
121. Head, J.F., Jiang, X., Fort, K.A., Dye, V.D., and Elliott, R.L.: Effective Treatment of 4T1
Mammary Adenocarcinoma by Direct Tumor Injection and Continuous Systemic Infusion of
Transferrin Receptor Antisense in Mice. Proc. Amer. Soc. Clin. Oncol. 25:14113, 2007.
122. Jiang, X.P., Elliott, R.L., and Head, J.F.: Transfection with the Ferroportin Gene Increases the
Cytotoxicity of the Iron Chelator Deferoxamine Mesylate to MCF-7 Human Breast Cancer
Cells. Proc. Amer. Assoc. Cancer Res. 49:899, 2008.
123. Elliott, R.L., DeLand, M.M., Head, J.F., and Elliott, M.C.: Accelerated Partial Breast
Irradiation: Preliminary Experience with the IntraBeam System. J. Clin. Oncol. 26:11581,
2008.
124. Head, J.F., Jiang, X.P., and Elliott, R.L.: Autologous Breast Cancer Vaccine Improves Host
Lymphocyte Immunity. The 6th International Cancer Vaccine Symposium (NYAS) 6:8,
2008.
125. Head, J.F., Jiang, X.P., and Elliott, R.L.: Autologous Breast Cancer Vaccine Improves Host
Lymphocyte Immunity (A Rationale for Immunotherapy). The 6th Annual Vaccines: All
Things Considered 6:7, 2008.
126. Elliott, R.L., and Head, J.F.: Autologous Vaccine Improves Host Immunity and Disease Free
Survival in Breast Cancer Patients. Ann. Surg. Oncol. 16S:P38, 2009.
127. Neacato, I.I., Daniels, T.R., Ortiz-Sanchez, E., Head, J.F., Elliott, R.L., Morgan, R.,
20
Bonavida, B., and Penichet, M.L.: Efficacy of Ga-Tf, HXR9, and their combination with an
anti-human TfR IgG3-avidin fusion protein in human hematopoietic malignant cells. Proc.
Amer. Assoc. Cancer Res. 50:209-210, 2009.
128. Jiang, X., Elliott, R.L., and Head, J.F.: Antisense Oligonucleotides Targeting the Large
Subunit (R1) of Human Ribonucleotide Reductase Synergistically Increase the Cytotoxicity
of Doxorubicin and Paclitaxel to MCF-7 Breast Cancer Cells. Proc. Amer. Soc. Clin.
Oncol. 27S:e14626, 2009.
129. Jiang, X.P., Elliott, R.L., and Head, J.F.: Conjugation of Doxorubicin to Transferrin
Overcomes Hypoxia-induced Drug Resistance in MCF-7 Cells and Multidrug Resistance of
NCI/ADR-Res Cells. World Molecular Imaging Conference 1c:915, 2009.
130. Head, J.F., and Elliott, R.L.: Intraoperative Radiotherapy with the IntraBeam System. Proc.
Am. Soc. Breast Disease 34:31, 2010.
131. Jiang, X.P., Phillips, J., Head, J.F., Barnett, B., and Elliott, R.L.: Upregulation of the
Expression of Nonclassical MHC Class I HLA-G Antigen in Human Breast Cancer Cell Lines
and Tissue. Proc. Amer. Assoc. Cancer Res. 51:1291, 2010.
132. Elliott, R.L., Jiang,X.P., and Head, J.F.: Reversal of Immune Suppression in Cancer by
Manipulation of Tumor Iron Metabolism. J. Immunother. 33:869, 2010.
133. Head, J.F., and Elliott, R.L.: Host Immunity and Disease Free Survival are Improved in Breast
Cancer Patients Receiving an Autologous Vaccine. J. Immunother. 33:916, 2010.
134. Elliott, R.L., DeLand, M., Miller, S., Goodrow, E., and Head, J.F.: Accelerated Partial Breast
Irradiation: Evaluation of the Intrabeam System. Sixth International Conference of the
International Society of Intraoperative Radiation Therapy 6:24, 2010.
135. Jiang, X.P., Elliott, R.L., Barnett, B.G., and Head, J.F.: The Regulation of the Cytolytic Function
of Natural Killer Cells on the MCF-7 Human Breast Cancer Cell Line by Iron. AACR Special
Conference on Tumor Immunology: Basic and Clinical Advances 1:101, 2010.
136. Serrero, G., Hawkins, D.M., Yue, B., Ioffe, O.B., Bejarano, P., Phillips, J.T., Head, J.F.,
Elliott, R.L., Godwin, A.K., Weaver, J., Kim, W., and Kamimura, S.: Association of GP88
(progranulin) tumor expression with decreased disease-free and overall survivals in breast
cancer patients with estrogen receptor positive invasive ductal carcinoma. Proc. Amer. Soc.
Clin. Oncol. 29:604, 2011.
137. Elliott, R.L., Deland, M.M., and Head, J.F.: Accelerated partial-breast irradiation with the
intrabeam intraoperative radiotherapy system. Proc. Amer. Soc. Clin. Oncol. 29:e11569,
2011.
138. Head, J.F., and Elliott, R.L.: Adjuvant Breast Cancer Vaccine Improves Overall Survival of
21
Breast Cancer Patients. CRI Immunotherapy Symposium 19:P59, 2011.
139. Head, J.F., and Elliott, R.L.: Adjuvant Breast Cancer Vaccine Improves Overall Survival of
Patients with Depressed Immunity. Proc. Amer. Assoc. Cancer Res. 53:5370, 2012.
140. Elliott, R.L., Jiang, X.P., Phillips, J.T., and Head, J.F.: Cancer Immunosuppression: The
Role of Human Leukocyte Antigen G Expression. Proc. Amer. Assoc. Cancer Res. 53:5409,
2012.
141. Elliott, R.L., and Head, J.F.: Introduction of Normal Mammary Epithelial Mitochondria into
MCF-7 Human Breast Cancer Cell Line Inhibits Proliferation and Increases Drug Sensitivity.
Microscopy and Microanalysis 70:130, 2012.
142. Head, J.F., Jiang, X.P., and Elliott, R.L.: Iron Upregulates HLA-G mRNA Expression of the
Human MCF-7 Breast Cancer Cell Line. Proc. Amer. Assoc. Cancer Res. 54:1507, 2013.
143. Elliott, R.L., Jiang, X.P., and Head, J.F.: Normal Mammary Epithelial Mitochondria
Introduced into Human Breast Cancer Cells Results in Inhibition of Proliferation and
Increased Drug Sensitivity of the MCF-7 Breast Cancer Cell Line. Proc. Amer. Assoc.
Cancer Res. 54:5420, 2013.
144. Elliott, R.L., and Head, J.F.: Effect of an Adjuvant Breast Cancer Vaccine on Diseasespecific Survival of Breast Cancer Patients with Depressed Lymphocyte Immunity. Proc.
Amer. Soc. Clin. Oncol. 31:3087, 2013.
145. Elliott, R.L., Jiang, X.P., and Head, J.F.: Effect of Glycolysis and Glucose Transporters of
Transplanted Isolated Normal Mitochondria fro MCF-12A Cells into Breast Cancer Cells.
Mitochondrial Medicine 2013: Mitochondrial Therapeutics – From Bench to Bedside
1:117, 2013.
146. Head, J.F., and Elliott, R.L.: Vaccination of Prostate Cancer Patients with a Therapeutic
Vaccine containing Prostate Specific Antigen (PSA) and Biological Adjuvants Results in
Reduced Serum PSA. CRI Immunotherapy Symposium 21:P23, 2013.
147. Head, J.F., and Elliott, R.L.: Vaccination of Prostate Cancer Patients with a Therapeutic
Vaccine containing Prostate Specific Antigen (PSA) and the Biological Adjuvants IL-2 and
GM-CSF Results in Reduced Serum PSA. Journal of Clinical and Cellular Immunology
4:31, 2013.
148. Head, J.F., and Elliott, R.L.: Vaccination with a Therapeutic Cancer Vaccine Containing
Prostate Specific Antigen and the Biological Adjuvants IL-2 and GM-CSF Results in
Reduced Serum PSA in Prostate Cancer Patients. Proc. Amer. Assoc. Cancer Res. 55:2892,
2014.
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149. Daniels, G.A., Wang-Rodriguez, J., Sakamoto, K., Ongkeko, W., McKinney, M., and Head,
J.F.: A phase 1A/1B, two-stage study of a PSA/IL-2/GM-CSF vaccine for the treatment of
PSA-recurrent prostate cancer in hormone-naive and hormone-independent patients. J. Clin.
Oncol. 32:5s, 2014 (suppl; abstr TPS3131).
150. Jiang, X.P., Philips, J., Elloitt, R.L., and Head, J.F.: Exogenous Normal Mammary Epithelial
Mitochondria Increase the Drug Sensitivity of Human Breast Cancer MCF-7 Cells. AACR
Precision Medicine Series, Drug Sensitivity and Resistance: Improving Cancer
Therapy. 53:A42, 2014.
151. Head, J.F., Daniels, G.A., McKinney, M., Ongkeko, W., Wang-Rodriguez, J., Sakamoto, K.
and Elliott, R.L.: A Phase 1 Study of a Therapeutic Prostate Cancer Vaccine Containing
PSA/IL-2/GM-CSF for the Treatment of PSA-recurrent Prostate Cancer in Hormone-naïve
and Hormone-independent Patients. CRI Immunotherapy Symposium 22:P50, 2014.
152. Chang, K.P., Kolli, B., Tripathi, P., Ng, D.K.P., Chang, C.S., Aikatani, S., Al-Qahtani, A., de
Oliveira, C.I., Mello, S., Manna, L., Gravino, A.E., Head, J.F., Elliott, R.L., and Batchu,
R.B.:
Photodynamic Vaccination: Novel Strategies of Vaccine Delivery by
Intraphagolysosomal Parasites and Their Oxidative Inactivation for Safe and Effective
Applications. Bacteriol. Parasitol. 5:4, 2014.
153. Head, J.F., Daniels, G.A., McKinney, M., Ongkeko, W., Wang-Rodriguez, J., Sakamoto, K.,
and Elliott, R.L.: A Phase 1a Clinical Trial of a Therapeutic Prostate Cancer Vaccine
Containing PSA/IL-2/GM-CSF in PSA-recurrent Prostate Cancer Patients. Proc. Amer.
Assoc. Cancer Res. 56:CT224, 2015.
154. Elliott, R.L., Jiang, X.P., and Head, J.F.: Glycolytic Cancer Cell Metabolism Suppressed by
Transplantation of Exogenous Normal Mitochondria into Human Breast Cancer Cells. Proc.
Metabolism Cancer 1:79 (A89), 2015.
155. Elliott, R.L., Jiang, X.P., and Head, J.F.: Exogenous Normal Mitochondria are Potential
Organelles for Cell-based Cancer Therapy. Cell Symposia; Mutifaceted Mitochondria
Online, 2015.
156. Head, J.F., Daniels, G.A., McKinney, M., Ongkeko, W., Wang-Rodriguez, J., Sakamoto, K.,
and Elliott, R.L.: Phase 1 Clinical Trial of a Therapeutic Prostate Cancer Vaccine Containing
PSA/IL-2/GM-CSF in PSA Defined Biochemical Recurrent Prostate Cancer Patients. The
Inaugural International Cancer Immunotherapy Conference: Translating Science Into
Survival 1:A048, 2015.
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Book Chapters
1.
Greengard, O., and Head, J.F.: Enzyme Pathology of Neoplasms and of Uninvolved Tissues of
the Host. In: T.J. Peters (ed.), Subcellular Pathology of Systemic Disease, pp. 43-65. London:
Chapman and Hall, Ltd., 1987.
2.
Amalu, W.C., Hobbins, W.B., Head, J.F., and Elliott,R.L.: Infrared Imaging of the Breast – An
Overview. In: J.D. Bronzino (ed.), Medical Devices and Systems, The Biomedical
Engineering Handbook, Third Edition, Chapter 25, pp. 1-21. Boca Raton, FL: CRC Press,
2006.
3.
Amalu, W.C., Hobbins, W.B., Head, J.F., and Elliott,R.L.: Infrared Imaging of the Breast: A
Review. In: N.A. Diakides and J.D. Bronzino (eds.), Medical Infrared Imaging, Chapter 9,
pp. 1-22. Boca Raton, FL: CRC Press, 2008.
4.
Amalu, W.C., Hobbins, W.B., Head, J.F., and Elliott,R.L.: Infrared Imaging of the Breast: A
Review. In: M. Diakides, J.D. Bronzino and D.R.Peterson (eds.), Medical Infrared
Imaging: Principles and Practices, Chapter 10. Boca Raton, FL: CRC Press, 2012.
CME Programs
1.
Elliott, R.L., and Head, J.F.: Stereotaxic Localization of Nonpalpable Breast Lesions. Medical
Portfolio for General Surgeons 11:1, 1997.
PROFESSIONAL SOCIETIES
American Association for the Advancement of Science
New York Academy of Sciences
American Association for Cancer Research
American Society of Clinical Oncology
Society for Immunotherapy of Cancer
European Society for Medical Oncology
The American Academy of Thermology
IEEE Engineering in Medicine and Biology Society
American Society of Breast Disease
24
CERTIFICATION AND LICENSURE
Clinical Laboratory Director (HCLD); American Board of Bioanalysis
Medical Laboratory Director--Clinical Chemistry; State of Tennessee
Clinical Laboratory Scientist--Specialist; State of Louisiana
The American Board of Thermology; Certified in Oncology
The American Board of Thermology; Certified in Vascular Medicine
EDITORIAL BOARDS
The Open Medicinal Chemistry Journal (Editor-in-Chief, 2007-2015)
Interactive Medicinal Chemistry (Editor-in-Chief)
Immunology Innovation (Editor-in-Chief)
Vaccines & Vaccination (Editor)
25
PATENTS
Vaccination Of Cancer Patients Using Tumor-Associated Antigens Mixed With Interleukin-2 And
Granulocyte-Macrophage Colony Stimulating Factor. U.S. Patent No. 5,478,556. Robert L. Elliott
and Jonathan F. Head.
Method For Selectively Culturing Epithelial Or Carcinoma Cells. U.S. Patent Application No.
10/918,741. Jonathan F. Head and Robert L. Elliott.
Vaccination of Cancer Patients (Whole Cell Vaccine).
Jonathan F. Head and Robert L. Elliott.
U.S. Patent Application No. 13/005,984.
Composition for a Cancer Vaccine (Protein Vaccine). U.S. Patent Application No. 13/005,993;
Continuation Application No. 14/137,060; U.S. Patent No. 8,647,627. Jonathan F. Head and
Robert L. Elliott.
Taxane- and Taxoid-Protein Compositions. U.S. Patent Application No. 13/017,173. Jonathan F.
Head and Robert L. Elliott.
GRANTS AND CONTRACTS
SBIR contract (Principal Investigator), Phase I, DOD (Army), $100,000/6 months, 7/15/95-1/15/96,
Development of Second Generation Thermography with Computerized Image Analysis for Breast
Cancer Diagnosis. Principal Investigator: Jonathan F. Head.
SBIR contract (Co-Investigator), Phase II, DOD (Army), $750,000/2 years. 1/15/96-1/15/98.
Office of Naval Research Contract (Co-Investigator), 2 years, 3/7/02-11/15/05, Development of a
Web-Based Database of Breast Infrared Images.
Naval Health Research Center Contract (Co-Investigator) $828,000/1 year, 7/2006-6/2007, US
Navy Cancer Vaccine Program, FISC San Diego Contract #N00244-06-P-2157, Prostate Cancer
Vaccine in Patients with Rising PSAs after Previous Therapy (Surgery, Radiotherapy, Radioactive
Seed Implants).
Naval Health Research Center Contract (Principal Investigator) $2,250,400/2 years, 8/2009-7/2011,
US Navy Cancer Vaccine Program, RDECOM Natick Contract #W911QY-09-C-0107, Prostate
Cancer Vaccine in Patients with Rising PSAs after Previous Therapy (Surgery, Radiotherapy,
Radioactive Seed Implants).
Naval Health Research Center Contract (Principal Investigator) $2,219,723/2 years, 9/2011-8/2013,
US Navy Cancer Vaccine Program, RDECOM Natick Contract #W911QY-11-C-0102, Prostate
Cancer Vaccine in Patients with Rising PSAs after Previous Therapy (Surgery, Radiotherapy,
Radioactive Seed Implants).
26