Download The physiology and biochemistry of the Paleolithic

The physiology and
biochemistry of the
Paleolithic Diet for
weight reduction
David C. Pendergrass, Ph.D.
University of Kansas
Glycolysis to Lipogenesis
TRPV1 Hypothesis
Nociceptor
monocyte
β- cell
TRPV1 – Physiological
Mediator
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Nociception
Inflammation
Infection
Immunity: Exposure to TRPV1 agonists
• Keratinocytes  PGE2 & IL-8
• PBMC  apoptosis
• Alimentary tract:
• Metabolism
• Hair growth regulation
• Cancer development
• Reduced obesity
• Smooth muscle cell regulation
• Anorexigenic signaling
TRPV1 • Agonists
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Thermosensing >43C; pain
Protons (pH < 5.2)
Capsaicin
Depolarizing voltage > + 60 mv (outwardly rectifying)
Stretch
TRPV1 • Sensitizing molecules
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17-β-estradiol
Anandamide
Olvanil
Omega-3 polyunsaturated FA
12-hydroperoxyeicosatetranoic acid (12-HPETE)
N-arachidonyl dopamine (NADA)
2-aminoethoxydiphenyl borate (2-APB)
Inflammatory mediators
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Growth factors
Neurotransmitters: bradykinin, serotonin, histamine, prostaglandins
Peptides and small proteins
Lipids
Chemokines
Cytokines
• Intracellular phosphorylation
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PKC
PKA
Tyrosine receptors kinases
Ca2+/CAM Kinase
TRPV1
• Desensitizing molecules
• PIP2
Sing-a-long
• If you’re healthy and you know it:
• If you’re healthy and you know it, Modern People
gotta show it, if you’re healthy and you know it:
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Eat GOOD meat
Don’t eat wheat
Eat GOOD fish
Make the switch
Eat your greens
Buy new jeans
Bibliography
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