Download Tamoxifen - University of Cincinnati

Windows of
Susceptibility
Breast
Cancer
Risk
tamoxifen
UNIVERSITY OF
Cincinnati
Dept of Env Hlth
Tamoxifen FAQS
WORD CLUEs
Across
1. A reduction in ______ is
one of the side effects of
tamoxifen,
2. When _________ ER
alpha translocates to the
cell nucleus,
3. Tamoxifen is
metabolized to endoxifen
which binds to estrogen
receptors in all cells
including cancer cells that
have them but differentially
and prevents binding of
estrogen,
4. Cytochrome p450s with
the acronym of ___
specifically CYP2D6 and
CYP3A4 and CYP 2C9 are
responsible for
metabolizing tamoxifen to
its most active form called endoxifen,
5. Cancer of the ______ has been linked to tamoxifen use,
6. Tamoxifen is metabolized into a molecule which is more active in inhibiting cell growth in
cells and tumor cells called ______,
7. Some of the effects of _______ include prevention of blood vessel damage and cardiac
hypertrophy and bone loss and osteoblast survival and libido as well as fluid resorption
from the colon and pain perception,
8. Tamoxifen use carries with it a greatly increased risk for developing an estrogen receptor
negative and more aggressive tumor,
9. The ____ term effects of tamoxifen has caused many physicians to limit the use to about
5 years
10. Any sequence of DNA which has unique sequence of base pairs that allows for
detection and identification can be used to customize therapy programs,
11. A drug which is similar to tamoxifen but with fewer side effects is ________.
12. Selective serotonin reuptake inhibitor drugs combined with low CYP2D6 are at
risk for ineffective tamoxifen therapy and these are Paxil, Zoloft and Prozac,
13. Anticancer drugs as chemotherapy which are working at less than optimal
values are said to be _________,
14. A common drug in chemotherapy specifically used for estrogen receptor positive
breast cancers,
15. Blood-_______ growth into tumors is somewhat inhibited by treatment with
tamoxifen and may relate to the estrogen receptor on smooth muscle cells,
16. The metabolism of tamoxifen changes with levels of _______ D and thus varies
with the season and probably also with supplements,
17. During the winter months lower amounts of circulating vitamin D have an effect
on the efficacy of tamoxifen,
.
Down
1. The accumulation of _____ in the liver or fatty liver is also a side effect of
tamoxifen,
2. An anticancer drug also called Arimidex gave significantly better results than
tamoxifen in terms of disease free survival but no mortality benefit,
3. ________ inhibitors have been used in stead of tamoxifen in treating post
menopausal breast cancer,
4. Metabolites of tamoxifen ____ to the estrogen receptor many times better than
tamoxifen itself,
5. The original research and development of tamoxifen was as a _____________,
6. This is the term used for tamoxifen's action on cancer cells and it refers to the fact
that tamoxifen does not actually kill cancer cells therefore does not cure cancer but
inhibits the growth of cells instead,
7. __alpha and __ beta are localized to the cell membrane but ER alpha can be
localized to the nucleus,
8. Since about 20 percent of all meds are metabolized by the same enzymes as
tamoxifen a full analysis of CYP2D6 is important,
9. Tamoxifen can reduce cognition and ________ memory,
10. A ________ is the chemical product resulting from the change in chemical
structure by enzymes,
11. About 80 ______ of all breast cancers are estrogen receptor positive and thus
can be treated by tamoxifen - like drugs,
12. The term for a drug that is metabolized to a more active compound is _______,
13. Tamoxifen-sreduced bone __________ occurs when it binds to the estrogen
receptor in osteoclasts in the bone,
14. There are risks associated with the long term use of tamoxifen just as there are
benefits of which one benefit is a reduced risk of a recurrence of a ER positive tumor,
15. Tamoxifen does not modify all estrogen activities thus it is referred to as a SERM or
________ estrogen receptor modulator,
16. Glandular cells of the breast and smooth muscle cells are among the cell _____
which have estrogen receptors,
17. Commercial names for tamoxifen are ______ and Istabal and Novadex,
Answers