Download Thomson Reuters Cortellis Competitive Intelligence for

Thomson Reuters Cortellis Competitive Intelligence for
Drug Discovery & Development
Session 1 Therapeutics Technologies Research: Pharmaceutical Discovery and
Development Workshop
Amabel Tan,
Life Sciences Solutions Consultant, Melbourne
Thomson Reuters
Phone: +61 3 9286 1485 Mobile: +61 466 481 359
[email protected]
Table of Contents
What is Competitive Intelligence?
Functionality of Cortellis Competitive Intelligence
How to Register and Login to Cortellis
Learning material and how to guides
Agenda
•  Competitive Intelligence…what is it and how is it
useful to me?
•  Intelligence tools to improve coverage, save time
and keep you up to date
•  Use case
•  Q&A
What is Competitive Intelligence?
What is the market/
medical need?
What is the
competition?
What are their
strengths,
weaknesses and
strategies? What are
mine?
What is the
commercial value of
these assets?
Aimpointresearch.com
What is the product/
IP/Technology-scape
Competitive Intelligence: Act of accessing all aspects of information around a topic to
understand the entirety of the current development landscape to strategize R&D activity,
business direction and investment opportunities-used by pharma/biotech/investors
What is Competitive Intelligence?
Aimpointresearch.com
Competitive Intelligence tools: enable you to systematically search and extract specific yet
comprehensive data from a single repository of scientific, clinical, intellectual property and
pharmaceutical information to give you the answers you need, faster
How is it useful to me?
But I already have a great research
proposal...isn’t it enough to say my
research has important implications for
the development of “insert topic here”
Whether applying for grants, writing publications/grants/funding applications
or prioritising R&D projects.....
it is becoming increasingly important to articulate
•  How your research addresses a unmet medical/clinical need
•  How this research leads to a novel or improved medical solution (drug,
combination treatment, diagnostic, biomarker etc) with clinical outcomes
•  That your research will result in a globally competitive outcome with
commercial/medical potential: technology/product (deliverability,
safety), protectable IP, economic benefits
•  Understand and benchmark the commercial value of your research/drug
asset
But I already have a great research
proposal...isn’t it enough to say my
research has important implications for
the development of “insert topic here”
How is it useful to me?
INCREASED OPPORTUNITIES
FOR FUNDING
SAVE TIME
Reduce time and noise trolling pubmed
and google
Increase QUALITY of grant-RATIONALE and
SIGNIFICANCE/INNOVATION section (25%)
Identify collaborators/ partners
Leverage content from GLOBAL
R&D drug activity
Support literature review writing/
grant and publication reviews
Cortellis Competitive Intelligence
COVERAGE
Manually curated
Fully indexed
Updated daily
>40,000 deals
>120,000
companies
-Benchmark comparable deals
>60,000 drugs/biologics
Discovery-Clinical Trial-Launch
Target-based action
Platform/Technology
SWOT
Sources: Conference
Reports,
Literature, Press
>130,000 clinical
trials (CT.gov)
releases, ClinicalProtocols
trial registries, Company reports,
Biomarkers
Thomson ReutersIntervention
Finance/ Thomson Innovation
Inclusion/exclusion
Patents/ Incidence Prevalence databases
>2.5 Million patents
-search by gene/protein target
-by patent type/technology
>50,000
Global conferences
Cortellis Competitive Intelligence
COVERAGE
>40,000 deals
What is the value of my
discovery/drug asset?
-Benchmark comparable deals
>120,000
companies
What are the limitations in
current SOC treatments for
GBM?
Is this target commercially viable?
What prior art exists?
>60,000 drugs/biologics
>130,000 clinical trials (CT.gov):
What predictive/diagnostic
biomarkers have been explored
for NSCLC?
>2.5 Million patents
-search by gene/protein target
-by patent type/technology
Has this target been previously
explored in Malaria?
>50,000
Global conferences
FUNCTIONALITY-ALERTS
Set up alerts
around drugs,
diseases, patents,
deals even
structures
Top 10 disease
targets for CXCR4
inhibitors
Export Mol files for
further analysis
FUNCTIONALITY- Patent and non-patent
searches
FUNCTIONALITY- Disease Briefings
1.
2.
3.
• 
• 
View market, health and economic burden
data-fully referenced
Evaluate current and in development
therapies
FUNCTIONALITY
1. Search
2. Select Content
1.
2.
3.
3. Filter
REGISTER FOR CORTELLIS
For first time users of Cortellis, go the the University of
Melbourne's library catalogue and click on connect to
Cortellis Competitive Intelligence
http://cat.lib.unimelb.edu.au/record=e1001620
2. Enter your University of Melbourne log in details
3. Click on Register and follow the
prompts.
You must use your University of
Melbourne email
TIP Bookmark login page and click “Remember me”
Use case 1
Target or pathway discovery
Wrap up
Our group has discovered a
compound with HSP70 inhibitory
activity.
ü  Searched & Filtered a drug target by
name
1.  Have we discovered a novel
therapeutic agent? Where have
similar molecules been explored
2.  What is the IP surrounding this
molecule?
3.  How can I track any emerging
developments
ü  Searched patents to view all patent
family members associated with the
target
ü  Ran a chemical structure search to
view similar previously discovered
structures-and their actions
ü  Exported a list of all related patents
ü  Set up Alerts to track developments
Use case 2
Disease drug development
landscape
Wrap up
I want to understand what is the
market/medical need for new drugs/
treatments for AML and the current
drug development landscape
ü  Viewed market/epidemiological
information with Disease Briefings
ü  Generated a full list of the AML drug
development pipeline
ü  Evaluated current treatment with
1.  What is the health/economic
SWOT analysis
impact of AML?
2.  What are the current drugs
ü  Analyzed historical deal value for
available and what are the
cancer drug/technology assets
limitation of these treatments?
3.  What is the potential deal value of ü  Set up Alert to track new deals in a
disease area
early stage cancer drug assets?
ADDITIONAL TRAINING AND SUPPORT
Help/Support
•  Online help file
Enhancements
•  Suggest an enhancement
•  Live Chat
–  add your own ideas
•  Learning Center
–  vote on suggestions
-training videos
-how to sheets
–  anonymous
For further information or training
Please contact
Amabel Tan, PhD
Life Science Solution Consultant
IP & Science
Thomson Reuters
Phone: +61 3 9286 1485 Mobile: +61 466 481 359
[email protected]
ip-science.thomsonreuters.com.au
Learning Material
•  20. Generate a visual drug pipeline with Spotfire
analystics
•  21. Benchmark comparable historical deals
•  22. Get the latest findings from International
Conferences
•  24. View latest drugs in development for a disease
•  32. Understand the IP surrounding your research
area
Spotfire Analytics-Highest development
status for Indication
To generate a funnel pipeline for drugs treating a particular indication, from the home page
1.  Scroll down to the ANALYSE portlet
2.  From ‘Choose the analysis type select ‘competitive intelligence matrix’
3.  From ‘Analysis entry point’ select indication (you can also choose a company/action)
4.  Type in your therapy area (i.e. Factor IX deficiency). Click on the analyse button
5.  Select the funnel tab.
Ensure you untick the False box in ‘drugs under development’ to remove drugs not being
actively developed (i.e. Discontinued, not under development)
For this example, only drugs in Phase 1 or able were selected using filters on the right.
Benchmark comparable historical deals
1. Search (generally based around a indication and stage of development
an indication), select Deal report type
2. Filter on status at deals start,
3. Further filer on
Type, indication etc
1.  Export to
Excel
2.  Analyse deal
size (total
and upfront/
Get the latest findings from International
Conferences
1.  Open conference
reports
2.  View upcoming
conferences
View latest drugs in development for a
disease
1.  Search Disease (or target, or
company etc)
2.  Hit Search
3.  Select Report Type (i.e. Drugs,
Clinical Trials, Patents etc)
All results where the search term
has appeared is shown
View latest drugs in development for a
disease- REFINE search to meet your criteria
1.  Scroll down, and to the left to
Show all filters or select Filters
from the top columns
2.  Indication: Select the disease
that the drug is designed to
treat
View latest drugs in development for a
disease- Further REFINE search based on drug
status, target and mode of action
1.  Pinpoint the development
status of the drug
2.  Identify the specific target
pathway
3.  View the mode of action
View latest drugs in development for a
disease- Quickly visualise and analyse trends
using rank by view
1.  Select the Rank by view function (pie chart)
2.  Select the information you want to analyse (i.e. Target-based
action, Technology or company)
3.  Hit Go to visualise trends in the area-and identify unexplored
opportunities
View latest drugs in development for a
disease- EXPORT and ALERT
1.  EXPORT the data as a table, or
full drug reports for use in
publications or grants
2.  ALERT to set up email alerts To
track changes and emerging
threats
3.  Alternatively save the search
Redirect your focus to Clinical trialsidentifying clinically relevant biomarkers
1.  SELECT the Clinical trials
report
2.  Hit Filters to refine search
3.  Select Condition, to ensure
trials focused on treating
Glioblastoma are selected
Redirect your focus to Clinical trialsidentifying clinically relevant biomarkers
1.  Select the role of biomarker-i.e
disease or therapeutic effect
2.  Select the method of
measurement (ie genomic or
cellular)
3.  Select the Biomarker of interest
Redirect your focus to Clinical trialsidentifying clinically relevant biomarkers
1.  Select the rank by view-Pie
chart
2.  Select Biomarker or topic to
analyse
3.  Hit Go to visualise the top
Disease biomarkers in
clinical trial evaluation for
Glioblastoma
Redirect your focus to Clinical trials-views
trials associated with Vaccines, or medical
devices
1.  Alternatively, Select the
Category filter, to narrow
down to a type of trial such
as Vaccines, or Medical
devices
Understand the IP surrounding your
research area-what is your FTO-what
protectable IP could you generate?
1.  Select Patents as the Report
type
2.  Open the Filters
3.  View the patents filed which
are associated with a
parthway or drug target
Understand the IP surrounding your
research area-what is your FTO-what
protectable IP could you generate?
1.  Use the Patent type to select
Patents associated with
Diagnostics (or Products,
drug combinations etc
ALTERNATIVELY VIEW
TECHNOLOGIES to select
platform like technologies
Understand the IP surrounding your research
area-what is your FTO-what protectable IP could you
generate?
1.  Use rank by view to visualise
the top trends in the IP
around your research area
2.  Export the results into a
table for further analysis
3.  Save or Alert on your search
to keep track of similar
emerging technologies