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Transcript 
Introduction to
Immunohematology
 Study
of human blood groups
• Blood bank department
• Donor blood and blood transfusions
• Tissue typing
• Forensic studies
• Genetic studies
• Paternity tests
• See Table 4-7
 William
Harvey, 1628
 James Blundell, 1818
 Karl Landsteiner, 1900, 1930
 First hospital blood bank, 1937
 Improvements after WW II
 Dramatic
advancements from
1950s–1980s
 AIDS
• Discovered in 1980s
• Caused major changes in blood donation
and transfusion practices
 Food
and Drug Administration (FDA)
• Regulates
 American
Association of Blood Banks
(AABB)
• Sets standards
• Accredits
 Donor
requirements
• Patient questionnaire
• Patient physical
• See Tables 4-8 and 4-9
 Donor
blood collection
• Maintain sterility
• 450 mL
• CPDA: anticoagulant plus nutrients
• Apheresis
 Processing
donor blood
• ABO and Rh typing
• Antibody screen
• Tests for infectious agents
 See Table 4-10
 Components
• Red blood cells
• Platelets
• Plasma, fresh frozen plasma (FFP)
 Trauma
victims
 Perfluorochemicals
 Cell-free stable hemoglobin
 Most
tests based on agglutination
• ABO grouping
• Rh typing
• Compatibility testing
• Tests for unusual antibodies
 Safety
 Quality
assessment
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