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Micro 201
Yuan Lecture 1, Class 22: Regulated Proteolysis and Development
April 13th, 2017
Overview
Regulated proteolysis plays a critical role in the biology of organisms across all
domains of life. As protein degradation represents an irreversible and energetically
costly process, cells have evolved mechanisms to ensure that only specific proteins
are destroyed at apppropriate times. In this session, we will explore how bacterial
proteases can operate in a substrate-specific manner. Specifically, we will discuss
how so-called "adaptor"-mediated proteolysis governs cell cycle progression in the
dimorphic bacterium Caulobacter crescentus.
Paper for Discussion
1. Joshi KK, Berge M, Radhakrishnan SK, Viollier PH, Chien P. (2015) An adaptor
hierarchy regulates proteolysis during a bacterial cell cycle. Cell 163:419-431.
Reviews
2. Gur E, Biran D, Ron EZ. Regulated proteolysis in Gram-negative bacteria  how
and when? (2011) Nat. Rev. Microbiol. 9:839-848.
3. Joshi KK, Chien P. (2016) Regulated proteolysis in bacteria: Caulobacter. Annu.
Rev. Genet. 50:423-445.
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