Download 벨빅작용기전 (다운 47회)

Mechanism of BELVIQ
Selectively 5-HT2C receptor agonist
Decrease food consumption and promote satiety
2C 수용체에 대한 선택성는 2A의 14배, 2B의 61배
Data on file
Mechanism of BELVIQ
시상하부
궁상핵
Mechanism of BELVIQ
궁상핵(in 시상하부)
Lorcaserin  POMC/CART 뉴런  5-HT2C 수용체 자극  αMSH 분비
LHA
 MC3/4 수용체 자극  식욕유발억제
PVN
 MC3/4 수용체 자극  식욕억제자극
체중
감소
Clinical Pharmacology & Therapeutics 2010, vol87(6), jun
Mechanism of BELVIQ
AgRP, agouti-related peptide; CART, cocaine- and amphetamine-regulated transcript; CCK, cholecystokinin; CCK1R, cholecystokinin receptor-1;
CTR, calcitonin receptor; CRH, corticotropin-releasing hormone; DVC, dorsal vagal complex; GHSR, growth hormone secretagogue receptor;
GLP1, glucagon-like peptide 1; GLP1R, glucagon-like peptide 1 receptor; H1R, histamine receptor-1; H3R, histamine receptor-3; 5HT2c, 5hydroxytryptamine receptor-2C; LepR, leptin receptor; LHA, lateral hypothalamic area; MC3/4R, melanocortin 3/4 receptor; MCH,
melanin-concentrating hormone; MCH1R, melanin-concentrating hormone receptor 1; αMSH, α-melanocyte-stimulating hormone; NPY,
neuropeptide Y; μ-OR, μ-opioid receptor; ORX, orexin; POMC, pro-opiomelanocortin; PP, pancreatic polypeptide; PVN, paraventricular nucleus;
TRH, thyrotropin-releasing hormone
Clinical Pharmacology & Therapeutics 2010, vol87(6), jun