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B7-2–positive myeloma: incidence, clinical characteristics,
prognostic significance, and implications for tumor
immunotherapy
by Belinda Pope, Ross D. Brown, John Gibson, Edna Yuen, and Doug Joshua
Blood
Volume 96(4):1274-1279
August 15, 2000
©2000 by American Society of Hematology
Plasma cells were clearly identified by high fluorescent intensity staining with CD38
(CD38++).(A,B) Cytoplasmic staining with anti-kappa and anti-lambda monoclonal antibodies
demonstrated light-chain restriction.
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
The immunophenotype of total plasma cells (CD38++) as well as plasma cell populations defined
by CD45 expression.Mature plasma cells were CD38++, CD45−; immature plasma cells were
CD38++, CD45+; and primitive plasma cells were CD38++, CD45++.
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
Kaplan-Meier survival curves for patients with increased CD86 expression on plasma cells at
diagnosis (B7-2–positive myeloma) compared with normal or reduced CD86 expression at
diagnosis (B7-2–negative myeloma).The median survival for B7-2–positive myeloma ...
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
Kaplan-Meier survival curves for patients with high (▴) and normal (▪) CD86 expression in
various cell subpopulations.(A) Mature plasma cell subpopulations (high CD86 greater than
60%).
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
Effect of culture with and without huCD40LT and IL-2 on CD80 and CD86 expression.Expression
was tested on peripheral blood B cells of patients with myeloma (▴; n = 9) and normal controls
(⋄; n = 5).
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
Effect of culture with and without IL-2 and huCD40LT on CD80 expression in various
cells.Expression was tested in bone marrow plasma cells as well as mature and primitive plasma
cells from patients with myeloma (n = 6).
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
Effect of culture with and without IL-2 and huCD40LT on CD86 expression in various
cells.Expression was tested in bone marrow plasma cells as well as mature and primitive plasma
cells from patients with myeloma (n = 6).
Belinda Pope et al. Blood 2000;96:1274-1279
©2000 by American Society of Hematology
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