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B7-2–positive myeloma: incidence, clinical characteristics, prognostic significance, and implications for tumor immunotherapy by Belinda Pope, Ross D. Brown, John Gibson, Edna Yuen, and Doug Joshua Blood Volume 96(4):1274-1279 August 15, 2000 ©2000 by American Society of Hematology Plasma cells were clearly identified by high fluorescent intensity staining with CD38 (CD38++).(A,B) Cytoplasmic staining with anti-kappa and anti-lambda monoclonal antibodies demonstrated light-chain restriction. Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology The immunophenotype of total plasma cells (CD38++) as well as plasma cell populations defined by CD45 expression.Mature plasma cells were CD38++, CD45−; immature plasma cells were CD38++, CD45+; and primitive plasma cells were CD38++, CD45++. Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology Kaplan-Meier survival curves for patients with increased CD86 expression on plasma cells at diagnosis (B7-2–positive myeloma) compared with normal or reduced CD86 expression at diagnosis (B7-2–negative myeloma).The median survival for B7-2–positive myeloma ... Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology Kaplan-Meier survival curves for patients with high (▴) and normal (▪) CD86 expression in various cell subpopulations.(A) Mature plasma cell subpopulations (high CD86 greater than 60%). Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology Effect of culture with and without huCD40LT and IL-2 on CD80 and CD86 expression.Expression was tested on peripheral blood B cells of patients with myeloma (▴; n = 9) and normal controls (⋄; n = 5). Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology Effect of culture with and without IL-2 and huCD40LT on CD80 expression in various cells.Expression was tested in bone marrow plasma cells as well as mature and primitive plasma cells from patients with myeloma (n = 6). Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology Effect of culture with and without IL-2 and huCD40LT on CD86 expression in various cells.Expression was tested in bone marrow plasma cells as well as mature and primitive plasma cells from patients with myeloma (n = 6). Belinda Pope et al. Blood 2000;96:1274-1279 ©2000 by American Society of Hematology
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