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Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia by Robert Iannone, Leo Luznik, Laura W. Engstrom, Sherrie L. Tennessee, Frederic B. Askin, James F. Casella, Thomas S. Kickler, Steven N. Goodman, Anita L. Hawkins, Constance A. Griffin, Lori Noffsinger, and Ephraim J. Fuchs Blood Volume 97(12):3960-3965 June 15, 2001 ©2001 by American Society of Hematology Progressively severe hematologic and pathologic changes in mixed hematopoietic chimeras containing an increasing percentage of HbS.Histologic images are shown for a representative sample of chimeric mice as follows: lethally irradiated C57BL/6 mouse reconst... Robert Iannone et al. Blood 2001;97:3960-3965 ©2001 by American Society of Hematology Progressive normalization of hematologic and histologic parameters in chimeric mice with increased normal myeloid chimerism and decreased fractions of sickle Hb.For percent normal myeloid chimerism, the percentage of normal myeloid chimerism, as measured by... Robert Iannone et al. Blood 2001;97:3960-3965 ©2001 by American Society of Hematology Nonlinear relationship of fraction of sickle Hb and percentage of sickle RBCs.A graph of the percent HbS as measured by HPLC versus a visual estimate of the percent sickle cell mouse– derived RBCs is compared to a predicted curve based on the difference in M... Robert Iannone et al. Blood 2001;97:3960-3965 ©2001 by American Society of Hematology
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