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Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells by Anna Dimberg, Inger Karlberg, Kenneth Nilsson, and Fredrik Öberg Blood Volume 102(1):254-261 July 1, 2003 ©2003 by American Society of Hematology ATRA treatment induces an early transient phosphorylation of Stat1 Ser727 in U-937 cells. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology Established U-937 sublines constitutively express exogenous Stat1Ser727Ala. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology Expression of Stat1Ser727Ala in U-937 cells inhibits ATRA-induced growth arrest. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology ATRA-induced down-regulation of cyclins A, B, D3, and E is inhibited by expression of Stat1Ser727Ala or Stat1Tyr701Phe. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology Expression of Stat1Ser727Ala or Stat1Tyr701Phe in U-937 cells inhibits ATRA-induced upregulation of p27 but not p21. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology The level of hyperphosporylated pRB is maintained after ATRA treatment in cells expressing Stat1Ser727Ala or Stat1Tyr701Phe. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology ATRA-induced down-regulation of c-Myc is inhibited by expression of Stat1Tyr701Phe or Stat1Ser727Ala. Anna Dimberg et al. Blood 2003;102:254-261 ©2003 by American Society of Hematology
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