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39 Beginning of the chapter Heart health and genetics (Cardiovascular Sensor) SENSORS CARDIOVASCULAR SENSOR Cholesterol/Triglycerides Homocysteine Arteriosclerosis Sudden cardiac arrest SENSORS CARDIOVASCULAR SENSOR Predisposition to: 1) High LDL cholesterol 2) Low HDL cholesterol 1) Effect of omega-3 on HDL cholesterol 3) High triglycerides 4) High homocysteine 1) Vitamin B2 positively effects the homocysteine levels 5) Prolongation of the QT intervals 6) Effect of 26 drugs CARDIOVASCULAR DISEASES 22 genetic variations CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Gene examples CARDIOVASCULAR DISEASES Genetic predisposition SENSORS CARDIOVASCULAR SENSOR Cardiovascular disease 1) Prevention 2) Early detection 3) Better treatment CARDIOVASCULAR DISEASES Counselling example Prevention Regular exercises Do not smoke! As little alcohol as possible Low-fat diet Less animal, more plant foods Use vegetable oils Omega3 fish oil capsules have a negative impact on your cholesterol Early detection Regular medical blood tests Submit to a Resting ECG examination before taking QT altering medication CARDIOVASCULAR DISEASES High risk, what to do now? Early detection Regular medical blood tests Regular QT interval tests Measure the electrolyte level when performing extreme sports SENSORS CARDIOVASCULAR SENSOR Cardiovascular disease 1) Prevention 2) Early detection 3) Better treatment PHARMACOGENETICS Various drugs and enzymes DRUG A DRUG B DRUG D DRUG C NAT2 2E9 1A2 2C19 2C9 2D6 break down 3A4 3A5 CARDIOVASCULAR DISEASES Optimal medication CARDIOVASCULAR DISEASES Optimal medication SENSORS CARDIOVASCULAR SENSOR Cardiovascular disease 1) Prevention 2) Early detection 3) Better treatment 39 End of the chapter Heart health and genetics (Cardiovascular Sensor)