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Transcript 
FoxO1 and FoxM1 Transcription Factors Have Antagonistic
Functions in Neonatal Cardiomyocyte Cell-Cycle
Withdrawal and IGF1 Gene RegulationNovelty and
Significance
by Arunima Sengupta, Vladimir V. Kalinichenko, and Katherine E. Yutzey
Circulation Research
Volume 112(2):267-277
January 18, 2013
Copyright © American Heart Association, Inc. All rights reserved.
AMP-activated protein kinase (AMPK) and forkhead box transcription factor (Fox) O activity is
increased, whereas the expression of FoxM1 is decreased, in mouse hearts after birth.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
AMP-activated protein kinase (AMPK) regulates cell-cycle activity in rat neonatal
cardiomyocytes.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
Activation of AMP-activated protein kinase (AMPK) promotes AKT inactivation with decreased
phosphorylation and increased nuclear localization of endogenous forkhead box transcription
factor (Fox) O1 and FoxO3 in neonatal cardiomyocytes.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
Forkhead box transcription factor (Fox) Os inhibit cell-cycle activity in rat neonatal
cardiomyocytes.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
Cardiomyocyte-specific loss of forkhead box transcription factor (Fox) O1 and FoxO3 results in
increased mitotic activity, whereas cardiomyocyte-specific loss of FoxM1 results in decreased
mitotic activity, in neonatal mouse hearts in vivo.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
Expression of IGF1 is increased with deficiency of forkhead box (Fox) transcription factor Os
and is decreased with loss of FoxM1, whereas expression of cell-cycle inhibitors is increased
with loss of FoxM1 in neonatal mouse hearts.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
Forkhead box (Fox) transcription factor M1 and FoxO1 have opposite effects on transcriptional
activity of the IGF1 promoter and binding is differentially regulated by AMP-activated protein
kinase (AMPK) in neonatal cardiomyocytes.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
Model for forkhead box (Fox) transcription factor O/FoxM1 function in controlling cell
proliferation of neonatal cardiomyocytes.
Arunima Sengupta et al. Circ Res. 2013;112:267-277
Copyright © American Heart Association, Inc. All rights reserved.
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