Download NM 4103 Section 4

NM 4103
Section 4
Radiopharmaceutical
Characteristics
99mTc
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Sodium Pertechnetate
Eluted from 99Mo generator
Tested for 99Mo and Al breakthrough
Can be used for preparation of 99mTc-labeled
radipharmaceuticals (kits) or
Used to image Thyroid and Meckel’s
diverticulum (without mixing in a kit)
99mTc

Preparation:
–
–
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–
–
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Heating HSA
Wash particles
Particles
–
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Macroaggregated Albumin (MAA)
Number: 1-12 million particles per mg
Shape: irregular
Size: 10-90 µm
Checked for particle size
Vial and syringe should be aggitated
Used for lung perfusion imaging
99mTc
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Kit Preparation:
–
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Add 99mTc to kit, mix
Weak chelates and tend to degrade with time
–
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Phosphates (MDP, HDP)
Prevented with tin and antioxidants
Used for bone imaging
99mTc
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Preparation:
–
–
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Add acid
Heat in water bath
Particles
–
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Sulfur Colloid
Size: 0.1 to 1 µm
Larger particles could be trapped in the lungs
Used for imaging liver/spleen, bone marrow,
lymphoscintigraphy, GI bleed, and gastric emptying.
99mTc
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Preparation
–
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Pentetate (DTPA)
Add 99mTc to kit, mix
Used for renal and aerosol lung imaging.
99mTc
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Preparation
–
In Vitro Method (Ultratag® kit)

–
Draw blood, add to vial of stannous citrate/acid citrate
dextrose(acd). Add sodium hypochlorite. Add ACD.
Add 99mTc and incubate.
In Vivo Method
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labeled Red Blood Cells
Sn2+ injected into patient. Wait 20 minutes, then 99mTc
injected into patient
Used to image GI bleed, liver hemangioma,
gated blood pool (MUGA)
99mTc
Iminodiacetic Acid (IDA)
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DISIDA (Hepatolite®) & Mebrofenin (Choletec®)
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Preparation
–
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Add 99mTc to kit, mix
Used for hepatobiliary imaging.
99mTc
Hexamethylpropylene Amine
Oxime (Ceretec®)
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Preparation of 99mTc HMPAO
–
Add 99mTc to kit, mix

Should be used within 4 hours of
preparation.

Used for brain imaging and labeling
leukocytes
99mTc

Preparation
–
–
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Sestamibi (Cardiolite®)
Add 99mTc to kit
Heat in boiling water bath for 10 minutes.
Used for imaging cardiac perfusion,
parathyroid adenomas and breast tumors
(Miraluma®).
99mTc
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Preparation
–
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Tetrofosmin (Myoview®)
Add 99mTc to kit, mix and incubate for 15 minutes.
Used for myocardial perfusion
99mTc
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MAG3
Preparation:
–
–
–
–
Add 99mTc to kit
Add filtered air (to oxidize excess Sn2+ )
Heat in water bath for 10 min
Cool for 15 min

Light sensitive
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Used for imaging renal function
99mTc
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Preparation:
–
–
–
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Neurolite®
Isotonic saline added to vial A
99mTc added to vial B
Add vial A to B and incubate for 30 minutes
Used for Brain perfusion imaging
99mTc
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DMSA
Preparation:
–
–
Add 99mTc to kit vial
Incubate for 10 minutes
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Light sensitive
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Used for renal cortical imaging
99mTc
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Gluceptate
Preparation:
– 99mTc
–
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addto kit vial
Incubate for 15 minutes
Used for renal imaging
131
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I Sodium Iodide
Supplied in capsule or liquid
Oral administration
Used for thyroid uptake measurement and
thyroid treatment
123
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I Sodium Iodide
Cyclotron produced
Capsule or liquid
Oral administration
Used for thyroid uptake measurement and
thyroid imaging
123

I or 131 I MIBG
Preparation
– 131I
–
–
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and MIBG is refluxed for 72 hrs
Cooled
Passed through anion exchange column
Used for imaging pheochromocytoma and for
treatment of neuroblastoma
111

Preparation:
–
–
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In DTPA
Adding dilute DTPA to solution of 111InCl3 in
acetate buffer, pH 5
Heat for 15 minutes in boiling water bath
Used for cisternography and gastric
emptying (liquid phase)
133
Xenon

Noble gas and is chemically inert
Produced by fission of 235U in the reactor

Shelf life is 14 days after calibration
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Should be handled in a proper fumehood
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Used for ventilation lung imaging
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201
Tl Thallous Chloride
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Cyclotron produced
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Used for myocardial perfusion imaging
111
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Blood is drawn
–
–
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In Labeled Leukocytes
Heparin or ACD added as anticoagulant
Hetastarch added to enhance sedimentation
Leukocytes are separated
–
Sedimentation, centrifuge, washing
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Labeled with 111In Oxine
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Used for detecting infection or abscesses.
99mTc
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Blood is drawn
–
–
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Labeled Leukocytes
Heparin or ACD added as anticoagulant
Hetastarch added to enhance sedimentation
Leukocytes are separated
–
Sedimentation, centrifuge, washing
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Labeled with 99mTc HMPAO (Ceretec®)
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Used for detecting inflammation, abscess or other
infections (also Chrohn’s disease)
111In
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Murine monoclonal antibody
Preparation:
–
–
–
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Prostascint®
111InCl3 added to vial
Incubate for 30 mintues
Filtered to remove particulate matter
Used for primary or metastatic prostate
cancer.
111In
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Radiolabeled Peptide
Preparation:
–
–
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Petetreotide (OctreoScan®)
111InCl3 added to reaction vial
Incubate for 30 minutes
Used for neuroendocrine tumors
–
Carcinoids, gastrinomas, neuroblastomas,
pituitary adenomas, medullary thyroid cancer