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IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells by Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann Blood Volume 114(2):346-356 July 9, 2009 ©2009 by American Society of Hematology IL-10Rα blockade restores HIV-specific CD4 T-cell function in individuals with uncontrolled viremia. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology IL-10-Rα blockade enhances cytokine secretion by HIV-specific CD4+ T cells. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology IL-10Rα blockade restores HIV-specific CTL function in individuals with uncontrolled viremia. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology IL-10 expression correlates with HIV viremia and response to IL-10Rα blockade. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology Relationships between IL-10 mRNA expression and disease stage. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology Longitudinal analysis during acute infection and the impact of therapy on IL-10 suggest an indirect link with plasma viremia. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology Broad expression of IL-10 mRNA in FACS-sorted cell subsets from HIV-infected subjects. Mark A. Brockman et al. Blood 2009;114:346-356 ©2009 by American Society of Hematology
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