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CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived
suppressor cells that inhibit T-cell responses and promote
TRegs
by Regina Jitschin, Martina Braun, Maike Büttner, Katja Dettmer-Wilde, Juliane
Bricks, Jana Berger, Michael J. Eckart, Stefan W. Krause, Peter J. Oefner, Katarina
Le Blanc, Andreas Mackensen, and Dimitrios Mougiakakos
Blood
Volume 124(5):750-760
July 31, 2014
©2014 by American Society of Hematology
Increased frequency of CD14+HLA-DRlo cells in the peripheral blood of untreated CLL patients.
Regina Jitschin et al. Blood 2014;124:750-760
©2014 by American Society of Hematology
Impact (in vitro and ex vivo) of CD14+HLA-DRlo cells from CLL patients on T cells.
Regina Jitschin et al. Blood 2014;124:750-760
©2014 by American Society of Hematology
CLL cells induce in vitro CD14+HLA-DRlo MDSCs with T-cell suppressive and TReg-promoting
capabilities.
Regina Jitschin et al. Blood 2014;124:750-760
©2014 by American Society of Hematology
Myeloid cells cosynergize with CLL cells in promoting TReg expansion.
Regina Jitschin et al. Blood 2014;124:750-760
©2014 by American Society of Hematology
CLL CD14+HLA-DRlo MDSCs express high levels of IDO. (A) The relative gene expression of
MDSC-related molecules was comparatively assessed in healthy control (HD) monocytes
cocultured with CLL cells (n = 7) in cell-to-cell contact, separated by a transwell s...
Regina Jitschin et al. Blood 2014;124:750-760
©2014 by American Society of Hematology
CLL CD14+HLA-DRlo MDSCs suppress T cells and induce TRegs through IDO. (A) Induced
(i)MDSCs converted from healthy control monocytes in the presence of CLL cells were
cocultured for 5 days with autologous VPD450-labeled activated T cells with/without being ...
Regina Jitschin et al. Blood 2014;124:750-760
©2014 by American Society of Hematology