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Transcript 
Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase,
and STAT5 Are Activated by Erythropoietin (EPO) in HCD57
Erythroid Cells But Are Constitutively Active in an EPOIndependent, Apoptosis-Resistant Subclone (HCD57-SREI
Cells)
by Haifeng Bao, Sarah M. Jacobs-Helber, Amy E. Lawson, Kalyani Penta, Amittha
Wickrema, and Stephen T. Sawyer
Blood
Volume 93(11):3757-3773
June 1, 1999
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
The tyrosine protein phosphatase, SHP-1, is equally expressed in HCD57, HCD57-SREI cells and
primary human erythroid cells.
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
PI 3-kinase was constitutively activated in HCD57 and HCD57-SREI cells.
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
PI 3-kinase activity associates with the EPOR and IRS-2.
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
Haifeng Bao et al. Blood 1999;93:3757-3773
©1999 by American Society of Hematology
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