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An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation by Kelli P. A. MacDonald, James S. Palmer, Stephen Cronau, Elke Seppanen, Stuart Olver, Neil C. Raffelt, Rachel Kuns, Allison R. Pettit, Andrew Clouston, Brandon Wainwright, Dan Branstetter, Jeffrey Smith, Raymond J. Paxton, Douglas Pat Cerretti, Lynn Bonham, Geoffrey R. Hill, and David A. Hume Blood Volume 116(19):3955-3963 November 11, 2010 ©2010 by American Society of Hematology Effect of anti-CSF1R mAb treatment on myeloid populations within lymphoid tissues. Kelli P. A. MacDonald et al. Blood 2010;116:3955-3963 ©2010 by American Society of Hematology Anti-CSF1R antibody mediated depletion of CSF1R-EGFP+ tissue macrophages. Kelli P. A. MacDonald et al. Blood 2010;116:3955-3963 ©2010 by American Society of Hematology Tissue-specific depletion of CSF1R-EGFP+ resident tissue macrophages with anti-CSF1R antibody. Kelli P. A. MacDonald et al. Blood 2010;116:3955-3963 ©2010 by American Society of Hematology Inflammation-mediated myeloid cell recruitment and macrophage-mediated wound healing are unaffected by anti-CSF1R treatment. Kelli P. A. MacDonald et al. Blood 2010;116:3955-3963 ©2010 by American Society of Hematology Treatment with anti-CSF1R prevented the recruitment of EGFP+ cells into tumor mass. Kelli P. A. MacDonald et al. Blood 2010;116:3955-3963 ©2010 by American Society of Hematology Treatment with anti-CSF1R exacerbates acute GVHD. (A) Survival by Kaplan-Meier analysis. Kelli P. A. MacDonald et al. Blood 2010;116:3955-3963 ©2010 by American Society of Hematology
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