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References for Table 1
References in order of their presentation in the table: Feldman AM, et al. Effects of vesnarinone on
morbidity and mortality in patients with heart failure. N Engl J Med. 1993;329:149-55. Cohn JN, et al. A
dose-dependent increase in mortality with vesnarinone among patients with severe heart failure.
Vesnarinone Trial Investigators. N Engl J Med. 1998;339:1810-6. Pitt B, et al. Randomised trial of
losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study,
ELITE). Lancet. 1997;349:747-52. Pitt B, et al. Effect of losartan compared with captopril on mortality in
patients with symptomatic heart failure: randomised trial--the Losartan Heart Failure Survival Study ELITE
II. Lancet. 2000;355:1582-7. Packer M, et al. Prospective Randomized Amlodipine Survival Evaluation
Study Group. N Engl J Med. 1996;335:1107-14. Packer M, et al. Effect of amlodipine on the survival of
patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2
study. JACC Heart Fail. 2013;1:308-14.
Torre-Amione G, et al: Effects of a novel immune modulation
therapy in patients with advanced chronic heart failure. J Am Coll Cardiol 2004;44:1181-1186. TorreAmione G, et al. Results of a non-specific immunomodulation therapy in chronic heart failure (ACCLAIM
trial): a placebo-controlled randomised trial. Lancet. 2008;371:228-36.
References for Table 2
References in order of their presentation in the table: CONSENSUS Trial Study Group. Effects of enalapril on
mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival
Study (CONSENSUS). N Engl J Med. 1987;316:1429-35. SOLVD Investigators. Effect of enalapril on survival
in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med.
1991;325:293-302. Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality
and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet.
1993;342:821-8. MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol
CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet. 1999;353:2001-7.
CIBIS II Investigators and Committees. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised
trial. Lancet. 1999;353:9-13. Packer M, et al. Effect of carvedilol on survival in severe chronic heart failure. N
Engl J Med. 2001;344:1651-8. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients
with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341:70917. Zannad F, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med.
2011;364:11-21.
Pitt B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular
dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309-21. Cohn JN, et al. Effect of vasodilator
therapy on mortality in chronic congestive heart failure. N Engl J Med. 1986;314:1547-52. Taylor AL, et al.
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351:204957.
References for Main Paper
1.
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR,
Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF
Investigators and Committees. Angiotensin-neprilysin inhibition versus
enalapril in heart failure. N Engl J Med. 2014;371:993-1004.
2.
Packer M. Unbelievable folly of clinical trials in heart failure: the
inconvenient truth about how investigators and guidelines weigh evidence.
Circ Heart Fail. 2016;9:e002837.
3.
Solomon SD, Claggett B, McMurray JJ, Hernandez AF, Fonarow GC.
Combined neprilysin and renin-angiotensin system inhibition in heart
failure with reduced ejection fraction: a meta-analysis. Eur J Heart Fail.
2016;18:1238-1243.
4.
Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in
Reducing Heart Failure Events After MI (PARADISE-MI). Available at:
https://clinicaltrials.gov/ct2/show/NCT02924727?term=sacubitril%2Fvalsar
tan+myocardial+infarction (November 5, 2016)
5.
ComParIson Of Sacubitril/valsartaN Versus Enalapril on Effect on NTpRoBNP in patients stabilized from an acute Heart Failure episode
(PIONEER-HF). Available at: https://clinicaltrials.gov/ct2/show/NCT
02554890?term=heart+failure%2C+sacubitril%2Fvalsartan&rank=2
(November 4, 2016).