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Pathophysiology and treatment of pulmonary hypertension in sickle cell disease by Victor R. Gordeuk, Oswaldo L. Castro, and Roberto F. Machado Blood Volume 127(7):820-828 February 18, 2016 ©2016 by American Society of Hematology Schematic representations of pulmonary hypertension. Victor R. Gordeuk et al. Blood 2016;127:820-828 ©2016 by American Society of Hematology Proposed algorithm for evaluation of pulmonary hypertension related to sickle cell disease. 6MWD, 6-minute walk distance; ANA, anti-nuclear antibody; CXR, chest X-ray; EKG, electrocardiogram; LFTs, liver function tests; mPAP, mean pulmonary artery pressure;... Victor R. Gordeuk et al. Blood 2016;127:820-828 ©2016 by American Society of Hematology