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Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation by Anna-Mari Kärkkäinen, Antti Kotimaa, Jenni Huusko, Ivana Kholova, Suvi Elina Heinonen, Anna Stefanska, Marike Hinke Dijkstra, Hanna Purhonen, Eveliina Hämäläinen, Petri Ilmari Mäkinen, Mikko Petri Turunen, and Seppo Ylä-Herttuala Blood Volume 113(18):4468-4475 April 30, 2009 ©2009 by American Society of Hematology Schematic presentation of the third generation lentiviral vector used in the transgenesis studies and Southern blot image of a copy number analysis. Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475 ©2009 by American Society of Hematology Human VEGF-D expression in TG mice. Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475 ©2009 by American Society of Hematology Blood and lymphatic capillary density in TG and control mice as shown by CD34, CD31, and LYVE-1 stainings. Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475 ©2009 by American Society of Hematology Morphologic characteristics in musculus caput gastrocnemius 7 days after hindlimb ischemia operation. Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475 ©2009 by American Society of Hematology Kaplan-Mayer survival curve showing tumor mortality of hVEGF-D TG mice and TG-negative controls. Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475 ©2009 by American Society of Hematology Representative histology of tumors in hVEGF-D TG mice. Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475 ©2009 by American Society of Hematology
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