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Transcript 
Vascular endothelial growth factor-D transgenic mice show
enhanced blood capillary density, improved postischemic
muscle regeneration, and increased susceptibility to tumor
formation
by Anna-Mari Kärkkäinen, Antti Kotimaa, Jenni Huusko, Ivana Kholova, Suvi Elina
Heinonen, Anna Stefanska, Marike Hinke Dijkstra, Hanna Purhonen, Eveliina
Hämäläinen, Petri Ilmari Mäkinen, Mikko Petri Turunen, and Seppo Ylä-Herttuala
Blood
Volume 113(18):4468-4475
April 30, 2009
©2009 by American Society of Hematology
Schematic presentation of the third generation lentiviral vector used in the transgenesis studies
and Southern blot image of a copy number analysis.
Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475
©2009 by American Society of Hematology
Human VEGF-D expression in TG mice.
Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475
©2009 by American Society of Hematology
Blood and lymphatic capillary density in TG and control mice as shown by CD34, CD31, and
LYVE-1 stainings.
Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475
©2009 by American Society of Hematology
Morphologic characteristics in musculus caput gastrocnemius 7 days after hindlimb ischemia
operation.
Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475
©2009 by American Society of Hematology
Kaplan-Mayer survival curve showing tumor mortality of hVEGF-D TG mice and TG-negative
controls.
Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475
©2009 by American Society of Hematology
Representative histology of tumors in hVEGF-D TG mice.
Anna-Mari Kärkkäinen et al. Blood 2009;113:4468-4475
©2009 by American Society of Hematology
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