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Multicollinearity Multicollinearity • Multicollinearity (or intercorrelation) exists when at least some of the predictor variables are correlated among themselves. • In observational studies, multicollinearity happens more often than not. • So, we need to understand the effects of multicollinearity on regression analyses. Example #1 120 BP 110 53.25 Age 47.75 97.325 Weight 89.375 2.125 BSA 1.875 8.275 Duration 4.425 72.5 Pulse 65.5 76.25 Stress 30.75 0 11 0 12 . 75 3.25 47 5 5 5 .37 7. 32 89 9 75 25 1. 8 2. 1 25 .275 4. 4 8 .5 65 .5 72 .75 6. 25 30 7 n = 20 hypertensive individuals p-1 = 6 predictor variables Example #1 Age Weight BSA Duration Pulse Stress BP 0.659 0.950 0.866 0.293 0.721 0.164 Age Weight BSA 0.407 0.378 0.344 0.619 0.368 0.875 0.201 0.659 0.034 0.131 0.465 0.018 Duration 0.402 0.312 Blood pressure (BP) is the response. Pulse 0.506 What is effect on regression analyses if predictors are perfectly uncorrelated? x1 2 2 2 2 4 4 4 4 x2 5 5 7 7 5 5 7 7 y 52 43 49 46 50 48 44 43 Pearson correlation of x1 and x2 = 0.000 Regress Y on X1 The regression equation is y = 48.8 - 0.63 x1 Predictor Constant x1 Coef 48.750 -0.625 Analysis of Variance Source DF SS Regression 1 3.13 Error 6 77.75 Total 7 80.88 SE Coef 4.025 1.273 MS 3.13 12.96 T 12.11 -0.49 F 0.24 P 0.000 0.641 P 0.641 Regress Y on X2 The regression equation is y = 55.1 - 1.38 x2 Predictor Constant x2 Analysis of Source Regression Error Total Coef 55.125 -1.375 SE Coef 7.119 1.170 Variance DF SS 1 15.13 6 65.75 7 80.88 MS 15.13 10.96 T 7.74 -1.17 F 1.38 P 0.000 0.285 P 0.285 Regress Y on X1 and X2 The regression equation is y = 57.0 - 0.63 x1 - 1.38 x2 Predictor Constant x1 x2 Coef 57.000 -0.625 -1.375 SE Coef 8.486 1.251 1.251 Analysis of Variance Source DF SS Regression 2 18.25 Error 5 62.63 Total 7 80.88 Source x1 x2 DF 1 1 Seq SS 3.13 15.13 MS 9.13 12.53 T 6.72 -0.50 -1.10 F 0.73 P 0.001 0.639 0.322 P 0.528 Regress Y on X2 and X1 The regression equation is y = 57.0 - 1.38 x2 - 0.63 x1 Predictor Constant x2 x1 Coef 57.000 -1.375 -0.625 SE Coef 8.486 1.251 1.251 Analysis of Variance Source DF SS Regression 2 18.25 Error 5 62.63 Total 7 80.88 Source x2 x1 DF 1 1 Seq SS 15.13 3.13 MS 9.13 12.53 T 6.72 -1.10 -0.50 F 0.73 P 0.001 0.322 0.639 P 0.528 If predictors are perfectly uncorrelated, then… • You get the same slope estimates regardless of the first-order regression model used. • That is, the effect on the response ascribed to a predictor doesn’t depend on the other predictors in the model. If predictors are perfectly uncorrelated, then… • The sum of squares SSR(X1) is the same as the sequential sum of squares SSR(X1|X2). • The sum of squares SSR(X2) is the same as the sequential sum of squares SSR(X2|X1). • That is, the marginal contribution of one predictor variable in reducing the error sum of squares doesn’t depend on the other predictors in the model. Same effects for “real data” with nearly uncorrelated predictors? Age Weight BSA Duration Pulse Stress BP 0.659 0.950 0.866 0.293 0.721 0.164 Age Weight BSA 0.407 0.378 0.344 0.619 0.368 0.875 0.201 0.659 0.034 0.131 0.465 0.018 Duration 0.402 0.312 Pulse 0.506 Regress BP on Stress The regression equation is BP = 113 + 0.0240 Stress Predictor Constant Stress S = 5.502 Analysis of Source Regression Error Total Coef 112.720 0.02399 SE Coef 2.193 0.03404 R-Sq = 2.7% Variance DF SS 1 15.04 18 544.96 19 560.00 T 51.39 0.70 P 0.000 0.490 R-Sq(adj) = 0.0% MS 15.04 30.28 F 0.50 P 0.490 Regress BP on BSA The regression equation is BP = 45.2 + 34.4 BSA Predictor Constant BSA S = 2.790 Coef 45.183 34.443 SE Coef 9.392 4.690 R-Sq = 75.0% Analysis of Variance Source DF SS Regression 1 419.86 Error 18 140.14 Total 19 560.00 T 4.81 7.34 P 0.000 0.000 R-Sq(adj) = 73.6% MS 419.86 7.79 F 53.93 P 0.000 Regress BP on BSA and Stress The regression equation is BP = 44.2 + 34.3 BSA + 0.0217 Stress Predictor Constant BSA Stress Analysis of Source Regression Error Total Source BSA Stress Coef 44.245 34.334 0.02166 SE Coef 9.261 4.611 0.01697 Variance DF SS 2 432.12 17 127.88 19 560.00 DF 1 1 Seq SS 419.86 12.26 MS 216.06 7.52 T 4.78 7.45 1.28 P 0.000 0.000 0.219 F 28.72 P 0.000 Regress BP on Stress and BSA The regression equation is BP = 44.2 + 0.0217 Stress + 34.3 BSA Predictor Constant Stress BSA Analysis of Source Regression Error Total Source Stress BSA Coef 44.245 0.02166 34.334 SE Coef 9.261 0.01697 4.611 Variance DF SS 2 432.12 17 127.88 19 560.00 DF 1 1 Seq SS 15.04 417.07 MS 216.06 7.52 T 4.78 1.28 7.45 F 28.72 P 0.000 0.219 0.000 P 0.000 If predictors are nearly uncorrelated, then… • You get similar slope estimates regardless of the first-order regression model used. • The sum of squares SSR(X1) is similar to the sequential sum of squares SSR(X1|X2). • The sum of squares SSR(X2) is similar to the sequential sum of squares SSR(X2|X1). What happens if the predictor variables are highly correlated? Age Weight BSA Duration Pulse Stress BP 0.659 0.950 0.866 0.293 0.721 0.164 Age Weight BSA 0.407 0.378 0.344 0.619 0.368 0.875 0.201 0.659 0.034 0.131 0.465 0.018 Duration 0.402 0.312 Pulse 0.506 Regress BP on Weight The regression equation is BP = 2.21 + 1.20 Weight Predictor Constant Weight S = 1.740 Coef 2.205 1.20093 SE Coef 8.663 0.09297 R-Sq = 90.3% Analysis of Variance Source DF SS Regression 1 505.47 Error 18 54.53 Total 19 560.00 T 0.25 12.92 P 0.802 0.000 R-Sq(adj) = 89.7% MS 505.47 3.03 F 166.86 P 0.000 Regress BP on BSA The regression equation is BP = 45.2 + 34.4 BSA Predictor Constant BSA S = 2.790 Analysis of Source Regression Error Total Coef 45.183 34.443 SE Coef 9.392 4.690 R-Sq = 75.0% Variance DF SS 1 419.86 18 140.14 19 560.00 T 4.81 7.34 P 0.000 0.000 R-Sq(adj) = 73.6% MS 419.86 7.79 F 53.93 P 0.000 Regress BP on BSA and Weight The regression equation is BP = 5.65 + 5.83 BSA + 1.04 Weight Predictor Constant BSA Weight Analysis of Source Regression Error Total Source BSA Weight Coef 5.653 5.831 1.0387 SE Coef 9.392 6.063 0.1927 Variance DF SS 2 508.29 17 51.71 19 560.00 DF 1 1 Seq SS 419.86 88.43 MS 254.14 3.04 T 0.60 0.96 5.39 F 83.54 P 0.555 0.350 0.000 P 0.000 Regress BP on Weight and BSA The regression equation is BP = 5.65 + 1.04 Weight + 5.83 BSA Predictor Constant Weight BSA Analysis of Source Regression Error Total Source Weight BSA Coef 5.653 1.0387 5.831 SE Coef 9.392 0.1927 6.063 Variance DF SS 2 508.29 17 51.71 19 560.00 DF 1 1 Seq SS 505.47 2.81 MS 254.14 3.04 T 0.60 5.39 0.96 F 83.54 P 0.555 0.000 0.350 P 0.000 Effect #1 of multicollinearity When predictor variables are correlated, the regression coefficient of any one variable depends on which other predictor variables are included in the model. Variables in model X1 b1 b2 1.20 ---- X2 ---- 34.4 X1, X2 1.04 5.83 Even correlated predictors not in the model can have an impact! • Regression of territory sales on territory population, per capita income, etc. • Against expectation, coefficient of territory population was determined to be negative. • Competitor’s market penetration, which was strongly positively correlated with territory population, was not included in model. • But, competitor kept sales down in territories with large populations. Effect #2 of multicollinearity When predictor variables are correlated, the marginal contribution of any one predictor variable in reducing the error sum of squares varies, depending on which other variables are already in model. SSR(X1) = 505.47 SSR(X2) = 419.86 SSR(X1|X2) = 88.43 SSR(X2|X1) = 2.81 Effect #3 of multicollinearity When predictor variables are correlated, the precision of the estimated regression coefficients decreases as more predictor variables are added to the model. Variables in model X1 se(b1) se(b2) 0.093 ---- X2 ---- 4.69 X1, X2 0.193 6.06 What is the effect on estimating mean or predicting new response? (2,92) Weight 100 95 90 85 1.75 1.85 1.95 2.05 BSA 2.15 2.25 Effect #4 of multicollinearity on estimating mean or predicting Y Weight 92 BSA 2 Fit SE Fit 95.0% CI 95.0% PI 112.7 0.402 (111.85,113.54) (108.94,116.44) 95.0% CI (112.76,115.38) 95.0% PI (108.06,120.08) Fit 114.1 BSA Weight 2 92 SE Fit 0.624 Fit SE Fit 95.0% CI 112.8 0.448 (111.93,113.83) 95.0% PI (109.08, 116.68) High multicollinearity among predictor variables does not prevent good, precise predictions of the response (within scope of model). What is effect on tests of individual slopes? The regression equation is BP = 45.2 + 34.4 BSA Predictor Constant BSA S = 2.790 Analysis of Source Regression Error Total Coef 45.183 34.443 SE Coef 9.392 4.690 R-Sq = 75.0% Variance DF SS 1 419.86 18 140.14 19 560.00 T 4.81 7.34 P 0.000 0.000 R-Sq(adj) = 73.6% MS 419.86 7.79 F 53.93 P 0.000 What is effect on tests of individual slopes? The regression equation is BP = 2.21 + 1.20 Weight Predictor Constant Weight S = 1.740 Coef 2.205 1.20093 SE Coef 8.663 0.09297 R-Sq = 90.3% Analysis of Variance Source DF SS Regression 1 505.47 Error 18 54.53 Total 19 560.00 T 0.25 12.92 P 0.802 0.000 R-Sq(adj) = 89.7% MS 505.47 3.03 F 166.86 P 0.000 What is effect on tests of individual slopes? The regression equation is BP = 5.65 + 1.04 Weight + 5.83 BSA Predictor Constant Weight BSA Coef 5.653 1.0387 5.831 Analysis of Source Regression Error Total Variance DF SS 2 508.29 17 51.71 19 560.00 Source Weight BSA DF 1 1 SE Coef 9.392 0.1927 6.063 MS 254.14 3.04 Seq SS 505.47 2.81 T 0.60 5.39 0.96 F 83.54 P 0.555 0.000 0.350 P 0.000 Effect #5 of multicollinearity on slope tests When predictor variables are correlated, hypothesis tests for βk = 0 may yield different conclusions depending on which predictor variables are in the model. Variables in model X2 b2 se(b2) t P-value 34.4 4.7 7.34 0.000 X1, X2 5.83 6.1 0.96 0.350 Summary comments • Tests for slopes should generally be used to answer a scientific question and not for model building purposes. • Even then, caution should be used when interpreting results when multicollinearity exists. (Think marginal effects.) Summary comments (cont’d) • Multicollinearity has little to no effect on estimation of mean response or prediction of future response. Diagnosing multicollinearity • Realized effects (changes in coefficients, changes in sequential sums of squares, etc.) of multicollinearity. • Scatter plot matrices. • Pairwise correlation coefficients among predictor variables. • Variance inflation factors (VIF).