Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Slide ()
Document related concepts
no text concepts found
Transcript
Fusion of a vesicle with the plasma membrane preserves the orientation of any integral proteins embedded in the vesicle bilayer. Initially, the amino terminal of the protein faces the lumen, or inner cavity, of such a vesicle. After fusion, the amino terminal is on the exterior surface of the plasma membrane. That the orientation of the protein has not been reversed can be perceived by noting that the other end of the molecule, the carboxyl terminal, is always immersed in the cytoplasm. The lumen of a vesicle and the outside of the cell are topologically equivalent. (Redrawn and modified, with permission, from Lodish HF, Rothman JE: The assembly of cell membranes. Sci Am [Jan] 1979;240:43.) Source: Chapter 46. Intracellular Traffic & Sorting of Proteins, Harper's Illustrated Biochemistry, 29e Citation: Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil P. Harper's Illustrated Biochemistry, 29e; 2012 Available at: http://mhmedical.com/ Accessed: June 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
Related documents