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Notch signaling is a critical regulator of allogeneic CD4+ Tcell responses mediating graft-versus-host disease by Yi Zhang, Ashley R. Sandy, Jina Wang, Vedran Radojcic, Gloria T. Shan, Ivy T. Tran, Ann Friedman, Koji Kato, Shan He, Shuaiying Cui, Elizabeth Hexner, Dale M. Frank, Stephen G. Emerson, Warren S. Pear, and Ivan Maillard Blood Volume 117(1):299-308 January 6, 2011 ©2011 by American Society of Hematology Inactivation of Notch signaling in donor CD4+ T cells inhibits acute GVHD in irradiated MHCmismatched hosts. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology Preserved GVT activity of DNMAML-expressing T cells. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology Preserved proliferation and in vivo expansion of DNMAML alloreactive CD4+ T cells. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology Impaired activation and cytokine response in alloreactive DNMAML CD4+ T cells. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology Hyporesponsiveness of alloreactive DNMAML CD4+ T cells to CD3/CD28-mediated signals, but significant preservation of cytotoxic potential. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology Notch inhibition prevents lethality in a nonirradiation semiallogeneic transplantation model. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology DNMAML-expressing alloreactive CD4+ and CD8+ T cells show impaired activation of many but not all effector differentiation pathways. Yi Zhang et al. Blood 2011;117:299-308 ©2011 by American Society of Hematology
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