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Long-Term Excessive Body Weight and Adult Left
Ventricular Hypertrophy Are Linked Through Later-Life
Body Size and Blood PressureNovelty and Significance
by Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez,
Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, and Wei Chen
Circulation Research
Volume 120(10):1614-1621
May 12, 2017
Copyright © American Heart Association, Inc. All rights reserved.
Covariates-adjusted mean values of adult LVMI by childhood and adulthood BMI and SBP status.
Huijie Zhang et al. Circ Res. 2017;120:1614-1621
Copyright © American Heart Association, Inc. All rights reserved.
Mediation effect of adult BMI and SBP on the childhood BMI–Adult LVMI association.
Huijie Zhang et al. Circ Res. 2017;120:1614-1621
Copyright © American Heart Association, Inc. All rights reserved.
Mediation effect of long-term burden of SBP on the association between long-term burden of
BMI and adult LVMI. A, Mediation effect of total SBP AUC. B, Mediation effect of incremental SBP
AUC. β indicates standardized regression coefficient; β1, indirect effect 1; β2, indirect effect 2;
βDir, direct effect; βInd, total indirect effect; βTot, total effect; AUC, area under the curve; BMI,
body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure. *P<0.05,
**P<0.01.
Huijie Zhang et al. Circ Res. 2017;120:1614-1621
Copyright © American Heart Association, Inc. All rights reserved.
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